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Mar. Drugs, Volume 3, Issue 4 (December 2005) – 3 articles , Pages 113-126

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Editorial
Farewell Address of Marine Drugs Executive Editor-in-Chief
by Peter Proksch
Mar. Drugs 2005, 3(4), 126; https://doi.org/10.3390/md304126 - 22 Dec 2005
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Abstract
After serving as the Executive Editor-in-Chief for Marine Drugs for almost three years I am now stepping back from this position but will remain attached to the Journal by serving on the Editorial Board.[...] Full article
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Article
Effects of Polybrominated Diphenol Ethers from a Marine Sponge Phyllospongia dendyi on IL-8 Production in a PMAstimulated Promyelocytic Leukemia Cell Line
by Taiko Oda, Hongwei Liu and Michio Namikoshi
Mar. Drugs 2005, 3(4), 119-125; https://doi.org/10.3390/md304119 - 3 Nov 2005
Cited by 10 | Viewed by 9015
Abstract
The effects of five polybrominated diphenol ethers from a Marine Sponge, Phyllospongia dendyi, on the relative plating efficiencies in V79 cells and the cell proliferation and IL-8 production in PMA-stimulated HL-60 cells were examined. Three compounds, possessing two phenol units, were reported to [...] Read more.
The effects of five polybrominated diphenol ethers from a Marine Sponge, Phyllospongia dendyi, on the relative plating efficiencies in V79 cells and the cell proliferation and IL-8 production in PMA-stimulated HL-60 cells were examined. Three compounds, possessing two phenol units, were reported to inhibit the assembly of microtubule proteins and showed the inhibition of colony formation of V79 cells and increase in IL-8 production. Interestingly, a monomethoxy compound exhibited the stronger activity than the three active compounds in both bioassays. This compound did not inhibit the assembly of microtubule proteins. A dimethoxy compound was not active in either bioassays. In these experimental conditions, the biological activities were not high, but in future, these compounds will be expected to be made stronger by structural modifications. Full article
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Article
Luteophanol D, New Polyhydroxyl Metabolite from Marine Dinoflagellate Amphidinium sp.
by Takaaki Kubota, Ayako Takahashi, Masashi Tsuda and Jun\'ichi Kobayashi
Mar. Drugs 2005, 3(4), 113-118; https://doi.org/10.3390/md304113 - 2 Nov 2005
Cited by 48 | Viewed by 8301
Abstract
Luteophanol D (1), a new polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from Okinawan marine acoel flatworm Pseudaphanostoma luteocoloris. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Luteophanol [...] Read more.
Luteophanol D (1), a new polyhydroxyl linear carbon-chain metabolite, has been isolated from the cultured marine dinoflagellate Amphidinium sp., which was isolated from Okinawan marine acoel flatworm Pseudaphanostoma luteocoloris. The structure of 1 was elucidated by detailed analyses of 2D NMR spectra. Luteophanol D (1) possesses two tetrahydropyran rings and twenty-three hydroxyl groups on C63-linear aliphatic chain with one exo-methylene and two methyl branches. Full article
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