A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans
Abstract
:1. Introduction
2. Subjects and Methods
2.1. Study Population
2.2. Thyroid Function
2.3. Anthropometry
2.4. Toxicological Analyses
2.5. Statistical Analysis
3. Results
3.1. Study Population
3.2. Toxicological Analysis
3.3. Partial Correlation Analysis
3.4. Regression Analysis for fT4
3.5. Regression Analysis for TSH
4. Discussion
5. Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
- Andersen, S.; Pedersen, K.M.; Bruun, N.H.; Laurberg, P. Narrow individual variations in serum t(4) and t(3) in normal subjects: A clue to the understanding of subclinical thyroid disease. J. Clin. Endocrinol. Metab. 2002, 87, 1068–1072. [Google Scholar] [CrossRef] [PubMed]
- Bauer, M.; Goetz, T.; Glenn, T.; Whybrow, P.C. The thyroid-brain interaction in thyroid disorders and mood disorders. J. Neuroendocrinol. 2008, 20, 1101–1114. [Google Scholar] [CrossRef] [PubMed]
- Kim, B. Thyroid hormone as a determinant of energy expenditure and the basal metabolic rate. Thyroid 2008, 18, 141–144. [Google Scholar] [CrossRef] [PubMed]
- Kahapola-Arachchige, K.M.; Hadlow, N.; Wardrop, R.; Lim, E.M.; Walsh, J.P. Age-specific TSH reference ranges have minimal impact on the diagnosis of thyroid dysfunction. Clin. Endocrinol. (Oxf.) 2012, 77, 773–779. [Google Scholar] [CrossRef] [PubMed]
- Vadiveloo, T.; Donnan, P.T.; Murphy, M.J.; Leese, G.P. Age- and gender-specific TSH reference intervals in people with no obvious thyroid disease in Tayside, Scotland: The thyroid epidemiology, audit, and research study (tears). J. Clin. Endocrinol. Metab. 2013, 98, 1147–1153. [Google Scholar] [CrossRef] [PubMed]
- Kussmaul, T.; Greiser, K.H.; Haerting, J.; Werdan, K.; Thiery, J.; Kratzsch, J. Thyroid analytes tsh, ft3 and ft4 in serum of healthy elderly subjects as measured by the roche modular system: Do we need age and gender dependent reference levels? Clin. Lab. 2014, 60, 1551–1559. [Google Scholar] [PubMed]
- Asvold, B.O.; Bjoro, T.; Vatten, L.J. Association of serum tsh with high body mass differs between smokers and never-smokers. J. Clin. Endocrinol. Metab. 2009, 94, 5023–5027. [Google Scholar] [CrossRef] [PubMed]
- Belin, R.M.; Astor, B.C.; Powe, N.R.; Ladenson, P.W. Smoke exposure is associated with a lower prevalence of serum thyroid autoantibodies and thyrotropin concentration elevation and a higher prevalence of mild thyrotropin concentration suppression in the third national health and nutrition examination survey (NHANES III). J. Clin. Endocrinol. Metab. 2004, 89, 6077–6086. [Google Scholar] [PubMed]
- Mehran, L.; Amouzgar, A.; Delshad, H.; Azizi, F. The association of cigarette smoking with serum TSH concentration and thyroperoxidase antibody. Exp. Clin. Endocrinol. Diabetes 2012, 120, 80–83. [Google Scholar] [CrossRef] [PubMed]
- Asvold, B.O.; Bjoro, T.; Nilsen, T.I.; Vatten, L.J. Tobacco smoking and thyroid function: A population-based study. Arch. Intern. Med. 2007, 167, 1428–1432. [Google Scholar] [CrossRef] [PubMed]
- Roef, G.; Lapauw, B.; Goemaere, S.; Zmierczak, H.G.; Toye, K.; Kaufman, J.M.; Taes, Y. Body composition and metabolic parameters are associated with variation in thyroid hormone levels among euthyroid young men. Eur. J. Endocrinol. 2012, 167, 719–726. [Google Scholar] [CrossRef] [PubMed]
- Asvold, B.O.; Vatten, L.J.; Nilsen, T.I.; Bjoro, T. The association between TSH within the reference range and serum lipid concentrations in a population-based study. The hunt study. Eur. J. Endocrinol. 2007, 156, 181–186. [Google Scholar] [CrossRef] [PubMed]
- Boas, M.; Feldt-Rasmussen, U.; Main, K.M. Thyroid effects of endocrine disrupting chemicals. Mol. Cell. Endocrinol. 2012, 355, 240–248. [Google Scholar] [CrossRef] [PubMed]
- Brucker-Davis, F. Effects of environmental synthetic chemicals on thyroid function. Thyroid 1998, 8, 827–856. [Google Scholar] [CrossRef] [PubMed]
- Surks, M.I.; Ortiz, E.; Daniels, G.H.; Sawin, C.T.; Col, N.F.; Cobin, R.H.; Franklyn, J.A.; Hershman, J.M.; Burman, K.D.; Denke, M.A.; et al. Subclinical thyroid disease: Scientific review and guidelines for diagnosis and management. JAMA 2004, 291, 228–238. [Google Scholar] [CrossRef] [PubMed]
- Nichols, B.R.; Hentz, K.L.; Aylward, L.; Hays, S.M.; Lamb, J.C. Age-specific reference ranges for polychlorinated biphenyls (PCB) based on the NHANES 2001–2002 survey. J. Toxicol. Environ. Health A 2007, 70, 1873–1877. [Google Scholar] [CrossRef] [PubMed]
- Pelletier, C.; Imbeault, P.; Tremblay, A. Energy balance and pollution by organochlorines and polychlorinated biphenyls. Obes. Rev. 2003, 4, 17–24. [Google Scholar] [CrossRef] [PubMed]
- Mrema, E.J.; Rubino, F.M.; Brambilla, G.; Moretto, A.; Tsatsakis, A.M.; Colosio, C. Persistent organochlorinated pesticides and mechanisms of their toxicity. Toxicology 2013, 307, 74–88. [Google Scholar] [CrossRef] [PubMed]
- Grimm, F.A.; Hu, D.; Kania-Korwel, I.; Lehmler, H.J.; Ludewig, G.; Hornbuckle, K.C.; Duffel, M.W.; Bergman, A.; Robertson, L.W. Metabolism and metabolites of polychlorinated biphenyls. Crit. Rev. Toxicol. 2015, 45, 245–272. [Google Scholar] [CrossRef] [PubMed]
- Letcher, R.J.; Klasson-Wehler, E.; Bergman, A. Methyl sulfone and hydroxylated metabolites of poylchlorinated biphenyls. Handb. Environ. Chem. 2000, 3, 315–359. [Google Scholar]
- McKinney, J.D. Multifunctional receptor model for dioxin and related compound toxic action: Possible thyroid hormone-responsive effector-linked site. Environ. Health Perspect. 1989, 82, 323–336. [Google Scholar] [CrossRef] [PubMed]
- Hallgren, S.; Darnerud, P.O. Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats-testing interactions and mechanisms for thyroid hormone effects. Toxicology 2002, 177, 227–243. [Google Scholar] [CrossRef]
- Hallgren, S.; Sinjari, T.; Hakansson, H.; Darnerud, P.O. Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch. Toxicol. 2001, 75, 200–208. [Google Scholar] [CrossRef] [PubMed]
- Liu, C.; Wang, C.; Yan, M.; Quan, C.; Zhou, J.; Yang, K. Pcb153 disrupts thyroid hormone homeostasis by affecting its biosynthesis, biotransformation, feedback regulation, and metabolism. Horm. Metab. Res. 2012, 44, 662–669. [Google Scholar] [CrossRef] [PubMed]
- Tang, J.M.; Li, W.; Xie, Y.C.; Guo, H.W.; Cheng, P.; Chen, H.H.; Zheng, X.Q.; Jiang, L.; Cui, D.; Liu, Y.; et al. Morphological and functional deterioration of the rat thyroid following chronic exposure to low-dose PCB118. Exp. Toxicol. Pathol. 2013, 65, 989–994. [Google Scholar] [CrossRef] [PubMed]
- Fisher, J.W.; Campbell, J.; Muralidhara, S.; Bruckner, J.V.; Ferguson, D.; Mumtaz, M.; Harmon, B.; Hedge, J.M.; Crofton, K.M.; Kim, H.; et al. Effect of PCB 126 on hepatic metabolism of thyroxine and perturbations in the hypothalamic-pituitary-thyroid axis in the rat. Toxicol. Sci. 2006, 90, 87–95. [Google Scholar] [CrossRef] [PubMed]
- Hood, A.; Hashmi, R.; Klaassen, C.D. Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy. Toxicol. Appl. Pharmacol. 1999, 160, 163–170. [Google Scholar] [CrossRef] [PubMed]
- Van der Plas, S.A.; Lutkeschipholt, I.; Spenkelink, B.; Brouwer, A. Effects of subchronic exposure to complex mixtures of dioxin-like and non-dioxin-like polyhalogenated aromatic compounds on thyroid hormone and vitamin A levels in female sprague-dawley rats. Toxicol. Sci. 2001, 59, 92–100. [Google Scholar] [CrossRef] [PubMed]
- Dallaire, R.; Muckle, G.; Dewailly, E.; Jacobson, S.W.; Jacobson, J.L.; Sandanger, T.M.; Sandau, C.D.; Ayotte, P. Thyroid hormone levels of pregnant Inuit women and their infants exposed to environmental contaminants. Environ. Health Perspect. 2009, 117, 1014–1020. [Google Scholar] [CrossRef] [PubMed]
- Bechaux, C.; Zeilmaker, M.; Merlo, M.; Bokkers, B.; Crepet, A. An integrative risk assessment approach for persistent chemicals: A case study on dioxins, furans and dioxin-like PCBs in france. Regul. Toxicol. Pharmacol. 2014, 70, 261–269. [Google Scholar] [CrossRef] [PubMed]
- Wild, D. The Immunoassay Handbook, 4th ed.; Elsevier: Amsterdam, The Netherlands, 2004. [Google Scholar]
- DeVito, M.; Biegel, L.; Brouwer, A.; Brown, S.; Brucker-Davis, F.; Cheek, A.O.; Christensen, R.; Colborn, T.; Cooke, P.; Crissman, J.; et al. Screening methods for thyroid hormone disruptors. Environ. Health Perspect. 1999, 107, 407–415. [Google Scholar] [CrossRef] [PubMed]
- Dirtu, A.C.; Dirinck, E.; Malarvannan, G.; Neels, H.; Van Gaal, L.; Jorens, P.G.; Covaci, A. Dynamics of organohalogenated contaminants in human serum from obese individuals during one year of weight loss treatment. Environ. Sci. Technol. 2013, 47, 12441–12449. [Google Scholar] [CrossRef] [PubMed]
- Phillips, D.L.; Pirkle, J.L.; Burse, V.W.; Bernert, J.T., Jr.; Henderson, L.O.; Needham, L.L. Chlorinated hydrocarbon levels in human serum: Effects of fasting and feeding. Arch. Environ. Contam. Toxicol. 1989, 18, 495–500. [Google Scholar] [CrossRef] [PubMed]
- Voorspoels, S.; Covaci, A.; Maervoet, J.; Schepens, P. Relationship between age and levels of organochlorine contaminants in human serum of a belgian population. Bull. Environ. Contam Toxicol. 2002, 69, 22–29. [Google Scholar] [CrossRef] [PubMed]
- Palma, C.C.; Pavesi, M.; Nogueira, V.G.; Clemente, E.L.; Vasconcellos, M.D.; Pereira, L.C.J.; Pacheco, F.F.; Braga, T.G.; Bello, L.D.; Soares, J.O.; et al. Prevalence of thyroid dysfunction in patients with diabetes mellitus. Diabetol. Metab. Syndr. 2013, 5, 58. [Google Scholar] [CrossRef] [PubMed]
- Langer, P.; Tajtakova, M.; Kocan, A.; Drobna, B.; Kostalova, L.; Fodor, G.; Klimes, I. Thyroid volume, iodine intake, autoimmune thyroid disorders, inborn factors, and endocrine disruptors: Twenty-year studies of multiple effects puzzle in Slovakia. Endocr. Regul. 2012, 46, 191–203. [Google Scholar] [CrossRef] [PubMed]
- Miyazaki, W.; Iwasaki, T.; Takeshita, A.; Kuroda, Y.; Koibuchi, N. Polychlorinated biphenyls suppress thyroid hormone receptor-mediated transcription through a novel mechanism. J. Biol. Chem. 2004, 279, 18195–18202. [Google Scholar] [CrossRef] [PubMed]
- Yang, H.; Chen, H.; Guo, H.; Li, W.; Tang, J.; Xu, B.; Sun, M.; Ding, G.; Jiang, L.; Cui, D.; et al. Molecular mechanisms of 2, 3’, 4, 4’, 5-pentachlorobiphenyl-induced thyroid dysfunction in frtl-5 cells. PLoS ONE 2015, 10, e0120133. [Google Scholar] [CrossRef] [PubMed]
- Chauhan, K.R.; Kodavanti, P.R.; McKinney, J.D. Assessing the role of ortho-substitution on polychlorinated biphenyl binding to transthyretin, a thyroxine transport protein. Toxicol. Appl. Pharmacol. 2000, 162, 10–21. [Google Scholar] [CrossRef] [PubMed]
- Cheek, A.O.; Kow, K.; Chen, J.; McLachlan, J.A. Potential mechanisms of thyroid disruption in humans: Interaction of organochlorine compounds with thyroid receptor, transthyretin, and thyroid-binding globulin. Environ. Health Perspect. 1999, 107, 273–278. [Google Scholar] [CrossRef] [PubMed]
- Fritsche, E.; Cline, J.E.; Nguyen, N.H.; Scanlan, T.S.; Abel, J. Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: Clue for involvement of thyroid hormone receptors. Environ. Health Perspect. 2005, 113, 871–876. [Google Scholar] [CrossRef] [PubMed]
- Gauger, K.J.; Giera, S.; Sharlin, D.S.; Bansal, R.; Iannacone, E.; Zoeller, R.T. Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome p4501a1 activation in rat pituitary gh3 cells. Environ. Health Perspect. 2007, 115, 1623–1630. [Google Scholar] [CrossRef] [PubMed]
- Dong, Y.; Tian, H.; Wang, W.; Zhang, X.; Liu, J.; Ru, S. Disruption of the thyroid system by the thyroid-disrupting compound aroclor 1254 in juvenile Japanese flounder (Paralichthys olivaceus). PLoS ONE 2014, 9, e104196. [Google Scholar] [CrossRef] [PubMed]
- Hood, A.; Klaassen, C.D. Differential effects of microsomal enzyme inducers on in vitro thyroxine (t(4)) and triiodothyronine (t(3)) glucuronidation. Toxicol. Sci. 2000, 55, 78–84. [Google Scholar] [CrossRef] [PubMed]
- Khan, M.A.; Hansen, L.G. Ortho-substituted polychlorinated biphenyl (PCB) congeners (95 or 101) decrease pituitary response to thyrotropin releasing hormone. Toxicol. Lett. 2003, 144, 173–182. [Google Scholar] [CrossRef]
- Yang, F.; Xu, Y.; Pan, H.; Wu, D. Induction of hepatic cytochrome p4501a1/2b activity and disruption of thyroglobulin synthesis/secretion by mono-ortho polychlorinated biphenyl and its hydroxylated metabolites in rat cell lines. Environ. Toxicol. Chem. 2008, 27, 220–225. [Google Scholar] [CrossRef] [PubMed]
- Lans, M.C.; Spiertz, C.; Brouwer, A.; Koeman, J.H. Different competition of thyroxine binding to transthyretin and thyroxine-binding globulin by hydroxy-PCBs, PCDDs and PCDFs. Eur. J. Pharmacol. 1994, 270, 129–136. [Google Scholar] [CrossRef]
- Schuur, A.G.; Brouwer, A.; Bergman, A.; Coughtrie, M.W.; Visser, T.J. Inhibition of thyroid hormone sulfation by hydroxylated metabolites of polychlorinated biphenyls. Chem. Biol. Interact. 1998, 109, 293–297. [Google Scholar] [CrossRef]
- Amano, I.; Miyazaki, W.; Iwasaki, T.; Shimokawa, N.; Koibuchi, N. The effect of hydroxylated polychlorinated biphenyl (oh-PCB) on thyroid hormone receptor (tr)-mediated transcription through native-thyroid hormone response element (TRE). Ind. Health 2010, 48, 115–118. [Google Scholar] [CrossRef] [PubMed]
- Kato, Y.; Haraguchi, K.; Kubota, M.; Seto, Y.; Ikushiro, S.; Sakaki, T.; Koga, N.; Yamada, S.; Degawa, M. 4-hydroxy-2, 2’, 3, 4’, 5, 5’, 6-heptachlorobiphenyl-mediated decrease in serum thyroxine level in mice occurs through increase in accumulation of thyroxine in the liver. Drug Metab. Dispos. 2009, 37, 2095–2102. [Google Scholar] [CrossRef] [PubMed]
- Dallaire, R.; Dewailly, E.; Pereg, D.; Dery, S.; Ayotte, P. Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults. Environ. Health Perspect. 2009, 117, 1380–1386. [Google Scholar] [CrossRef] [PubMed]
- Hagmar, L.; Rylander, L.; Dyremark, E.; Klasson-Wehler, E.; Erfurth, E.M. Plasma concentrations of persistent organochlorines in relation to thyrotropin and thyroid hormone levels in women. Int. Arch. Occup. Environ. Health 2001, 74, 184–188. [Google Scholar] [CrossRef] [PubMed]
- Eguchi, A.; Nomiyama, K.; Minh Tue, N.; Trang, P.T.; Hung Viet, P.; Takahashi, S.; Tanabe, S. Residue profiles of organohalogen compounds in human serum from e-waste recycling sites in North Vietnam: Association with thyroid hormone levels. Environ. Res. 2015, 137, 440–449. [Google Scholar] [CrossRef] [PubMed]
- Hagmar, L.; Bjork, J.; Sjodin, A.; Bergman, A.; Erfurth, E.M. Plasma levels of persistent organohalogens and hormone levels in adult male humans. Arch. Environ. Health 2001, 56, 138–143. [Google Scholar] [CrossRef] [PubMed]
- Persky, V.; Piorkowski, J.; Turyk, M.; Freels, S.; Chatterton, R., Jr.; Dimos, J.; Bradlow, H.L.; Chary, L.K.; Burse, V.; Unterman, T.; et al. Polychlorinated biphenyl exposure, diabetes and endogenous hormones: A cross-sectional study in men previously employed at a capacitor manufacturing plant. Environ. Health 2012, 11, 57. [Google Scholar] [CrossRef] [PubMed]
- Rylander, L.; Wallin, E.; Jonssson, B.A.; Stridsberg, M.; Erfurth, E.M.; Hagmar, L. Associations between cb-153 and p,p’-dde and hormone levels in serum in middle-aged and elderly men. Chemosphere 2006, 65, 375–381. [Google Scholar] [CrossRef] [PubMed]
- Meeker, J.D.; Altshul, L.; Hauser, R. Serum pcbs, p,p’-dde and hcb predict thyroid hormone levels in men. Environ. Res. 2007, 104, 296–304. [Google Scholar] [CrossRef] [PubMed]
- Bloom, M.S.; Weiner, J.M.; Vena, J.E.; Beehler, G.P. Exploring associations between serum levels of select organochlorines and thyroxine in a sample of new york state sportsmen: The new york state angler cohort study. Environ. Res. 2003, 93, 52–66. [Google Scholar] [CrossRef]
- Langer, P.; Kocan, A.; Tajtakova, M.; Radikova, Z.; Petrik, J.; Koska, J.; Ksinantova, L.; Imrich, R.; Huckova, M.; Chovancova, J.; et al. Possible effects of persistent organochlorinated pollutants cocktail on thyroid hormone levels and pituitary-thyroid interrelations. Chemosphere 2007, 70, 110–118. [Google Scholar] [CrossRef] [PubMed]
- Langer, P.; Tajtakova, M.; Fodor, G.; Kocan, A.; Bohov, P.; Michalek, J.; Kreze, A. Increased thyroid volume and prevalence of thyroid disorders in an area heavily polluted by polychlorinated biphenyls. Eur. J. Endocrinol. 1998, 139, 402–409. [Google Scholar] [CrossRef] [PubMed]
- Persky, V.; Turyk, M.; Anderson, H.A.; Hanrahan, L.P.; Falk, C.; Steenport, D.N.; Chatterton, R., Jr.; Freels, S. The effects of PCB exposure and fish consumption on endogenous hormones. Environ. Health Perspect. 2001, 109, 1275–1283. [Google Scholar] [CrossRef] [PubMed]
- Sala, M.; Sunyer, J.; Herrero, C.; To-Figueras, J.; Grimalt, J. Association between serum concentrations of hexachlorobenzene and polychlorobiphenyls with thyroid hormone and liver enzymes in a sample of the general population. Occup. Environ. Med. 2001, 58, 172–177. [Google Scholar] [CrossRef] [PubMed]
- Abdelouahab, N.; Mergler, D.; Takser, L.; Vanier, C.; St-Jean, M.; Baldwin, M.; Spear, P.A.; Chan, H.M. Gender differences in the effects of organochlorines, mercury, and lead on thyroid hormone levels in lakeside communities of Quebec (Canada). Environ. Res. 2008, 107, 380–392. [Google Scholar] [CrossRef] [PubMed]
- Gerhard, I.; Daniel, V.; Link, S.; Monga, B.; Runnebaum, B. Chlorinated hydrocarbons in women with repeated miscarriages. Environ. Health Perspect. 1998, 106, 675–681. [Google Scholar] [CrossRef] [PubMed]
- Langer, P.; Kocan, A.; Tajtakova, M.; Petrik, J.; Chovancova, J.; Drobna, B.; Jursa, S.; Pavuk, M.; Trnovec, T.; Sebokova, E.; et al. Human thyroid in the population exposed to high environmental pollution by organochlorinated pollutants for several decades. Endocr. Regul. 2005, 39, 13–20. [Google Scholar] [PubMed]
- Turyk, M.E.; Anderson, H.A.; Freels, S.; Chatterton, R., Jr.; Needham, L.L.; Patterson, D.G., Jr.; Steenport, D.N.; Knobeloch, L.; Imm, P.; Persky, V.W. Associations of organochlorines with endogenous hormones in male great lakes fish consumers and nonconsumers. Environ. Res. 2006, 102, 299–307. [Google Scholar] [CrossRef] [PubMed]
- Turyk, M.E.; Anderson, H.A.; Persky, V.W. Relationships of thyroid hormones with polychlorinated biphenyls, dioxins, furans, and dde in adults. Environ. Health Perspect. 2007, 115, 1197–1203. [Google Scholar] [CrossRef] [PubMed]
- Dalton, T.P.; Kerzee, J.K.; Wang, B.; Miller, M.; Dieter, M.Z.; Lorenz, J.N.; Shertzer, H.G.; Nerbert, D.W.; Puga, A. Dioxin exposure is an environmental risk factor for ischemic heart disease. Cardiovasc. Toxicol. 2001, 1, 285–298. [Google Scholar] [CrossRef]
- La Merrill, M.; Emond, C.; Kim, M.J.; Antignac, J.P.; Le Bizec, B.; Clement, K.; Birnbaum, L.S.; Barouki, R. Toxicological function of adipose tissue: Focus on persistent organic pollutants. Environ. Health Perspect. 2013, 121, 162–169. [Google Scholar] [PubMed]
- Rodondi, N.; den Elzen, W.P.; Bauer, D.C.; Cappola, A.R.; Razvi, S.; Walsh, J.P.; Asvold, B.O.; Iervasi, G.; Imaizumi, M.; Collet, T.H.; et al. Subclinical hypothyroidism and the risk of coronary heart disease and mortality. JAMA 2010, 304, 1365–1374. [Google Scholar] [CrossRef] [PubMed]
- Iwen, K.A.; Schroder, E.; Brabant, G. Thyroid hormones and the metabolic syndrome. Eur. Thyroid. J. 2013, 2, 83–92. [Google Scholar] [CrossRef] [PubMed]
- Dirinck, E.L.; Dirtu, A.C.; Govindan, M.; Covaci, A.; Van Gaal, L.F.; Jorens, P.G. Exposure to persistent organic pollutants: Relationship with abnormal glucose metabolism and visceral adiposity. Diabetes Care 2014, 37, 1951–1958. [Google Scholar] [CrossRef] [PubMed]
Characteristics | No. | Percentage | Mean ± SD | Range |
---|---|---|---|---|
Gender | ||||
Female | 123 | 68 | ||
Male | 57 | 32 | ||
Smoking | ||||
Yes | 28 | 16 | ||
No | 152 | 84 | ||
Age | 180 | 41 ± 13 | 18–84 | |
BMI | 180 | 35.1 ± 8.6 | 17.5–62.3 | |
All subjects | ||||
TSH (mU/L) | 180 | 1.66 ± 0.80 | 0.34–5.05 | |
fT4 (pmol/L) | 180 | 13.5 ± 2.1 | 9.3–20.0 | |
Female subjects | 123 | |||
TSH (mU/L) * | 123 | 1.74 ± 0.77 | 0.40–3.58 | |
fT4 (pmol/L) | 123 | 13.5 ± 1.9 | 9.3–19.3 | |
Male subjects | 57 | |||
TSH (mU/L) * | 57 | 1.51 ± 0.84 | 0.34–5.05 | |
fT4 (pmol/L) | 57 | 13.4 ± 2.4 | 10.3–20.0 |
Linear Regression Model | |||||
---|---|---|---|---|---|
POP | Significance | R2 | β (95% CI) | p | |
PCB95lw | 0.024 | 0.072 | |||
Gender | −0.024 (−0.113–0.066) | 0.604 | |||
Age | −0.001 (−0.004–0.003) | 0.754 | |||
BMI | 0.007 (0.002–0.012) | 0.004 | |||
Smoking status | 0.041 (−0.071–0.154) | 0.470 | |||
PCB95lw | −0.299 (−0.595–0.002) | 0.048 | |||
PCB99lw | 0.024 | 0.071 | |||
Gender | −0.026 (−0.116–0.064) | 0.566 | |||
Age | −0.003 (−0.007–0.001) | 0.108 | |||
BMI | 0.006 (0.001–0.011) | 0.012 | |||
Smoking status | 0.046 (−0.066–0.158) | 0.421 | |||
PCB99lw | 0.143 (0.000–0.285) | 0.049 | |||
PCB149lw | 0.017 | 0.076 | |||
Gender | −0.030 (−0.121–0.062) | 0.586 | |||
Age | −0.001 (−0.005–0.004) | 0.720 | |||
BMI | 0.006 (0.002–0.011) | 0.009 | |||
Smoking status | 0.046 (−0.069–0.161) | 0.505 | |||
PCB149lw | −0.248 (−0.471–0.025) | 0.030 | |||
3HO-PCB118 | 0.002 | 0.112 | |||
Gender | −0.024 (−0.113–0.065) | 0.592 | |||
Age | 0.001 (−0.002–0.005) | 0.442 | |||
BMI | 0.005 (0.000–0.010) | 0.061 | |||
Smoke | 0.060 (−0.053–0.173) | 0.293 | |||
Total lipids | 0.000 (−0.001–0.000) | 0.024 | |||
3HO-PCB118 | −0.147 (−0.267–0.028) | 0.016 | |||
3HO-PCB180 | 0.003 | 0.110 | |||
Gender | −0.041 (−0.130–0.049) | 0.381 | |||
Age | −0.002 (−0.007–0.002) | 0.257 | |||
BMI | 0.010 (0.005–0.015) | 0.000 | |||
Smoke | 0.083 (−0.030–0.196) | 0.148 | |||
Total lipids | 0.000 (−0.001–0.000) | 0.020 | |||
3HO-PCB180 | 0.287 (0.047–0.527) | 0.020 |
Variable | Β (95%CI) | P |
---|---|---|
Constant | 3.563 (3.303–3.823) | <0.001 |
Gender | −0.015 (−0.100–0.071) | 0.734 |
Age | −0.006 (−0.011–0.002) | 0.007 |
Current smoking | −0.023 (−0.069–0.023) | 0.321 |
BMI | 0.007 (0.001–0.012) | 0.013 |
PCB95lw | −0.412 (−0.763–0.061) | 0.022 |
PCB99lw | 0.309 (0.143–0.474) | <0.001 |
PCB149lw | −0.174 (−0.470–0.122) | 0.248 |
3HO-PCB118 | −0.104 (−0.233–0.025) | 0.114 |
3HO-PCB180 | 0.251 (0.008–0.494) | 0.043 |
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Dirinck, E.; Dirtu, A.C.; Malarvannan, G.; Covaci, A.; Jorens, P.G.; Van Gaal, L.F. A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans. Int. J. Environ. Res. Public Health 2016, 13, 421. https://doi.org/10.3390/ijerph13040421
Dirinck E, Dirtu AC, Malarvannan G, Covaci A, Jorens PG, Van Gaal LF. A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans. International Journal of Environmental Research and Public Health. 2016; 13(4):421. https://doi.org/10.3390/ijerph13040421
Chicago/Turabian StyleDirinck, Eveline, Alin C. Dirtu, Govindan Malarvannan, Adrian Covaci, Philippe G. Jorens, and Luc F. Van Gaal. 2016. "A Preliminary Link between Hydroxylated Metabolites of Polychlorinated Biphenyls and Free Thyroxin in Humans" International Journal of Environmental Research and Public Health 13, no. 4: 421. https://doi.org/10.3390/ijerph13040421