Evaluation of the Association between Gestational Diabetes Mellitus at First Pregnancy and Cancer within 10 Years Postpartum Using National Health Insurance Data in South Korea
Abstract
:1. Introduction
2. Methods
2.1. Study Design and Population
2.2. Primary Outcomes and Pre-Pregnancy Factors
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Variables | GDM | p-Value | |
---|---|---|---|
Yes (n = 4970) | No (n = 97,930) | ||
Age (year) | 28.25 (±3.28) | 27.28 (±3.02) | <0.0001 |
AMA | 3.98% (198) | 1.64% (1608) | <0.0001 |
Diabetes after delivery | 9.46% (470) | 5.26% (5147) | <0.0001 |
BMI (Kg/M2) | 20.98 (±2.74) | 20.77 (±6.74) | <0.0001 |
Smoking | 1.85% (92) | 2.01% (1970) | 0.0406 |
Fasting glucose | 85.99 (±20.97) | 85.09 (±17.44) | 0.0032 |
Variables | GDM † | Unadjusted | Adjusted †† | |||||
---|---|---|---|---|---|---|---|---|
Yes | No | HR | 95% CI | p-Value | HR | 95% CI | p-Value | |
Thyroid Cancer | 131 (2.64%) | 1822 (1.86%) | 1.34 | 1.114–1.617 | 0.002 | 1.27 | 1.054–1.532 | 0.012 * |
Gynecologic cancerother than ovary cancer | 29 (0.58%) | 388 (0.40%) | 1.29 | 0.830–2.005 | 0.258 | 1.32 | 0.846–2.050 | 0.223 |
Ovary cancer | 81 (1.63%) | 1067 (1.09%) | 1.28 | 0.938–1.738 | 0.12 | 1.23 | 0.901–1.673 | 0.193 |
Blood cancer | 3 (0.06%) | 30 (0.03%) | 1.65 | 0.391–6.999 | 0.494 | 1.52 | 0.357–6.445 | 0.573 |
Gastric cancer | 16 (0.32%) | 234 (0.24%) | 1.52 | 0.915–2.530 | 0.105 | 1.41 | 0.845–2.345 | 0.189 |
Hepatoma | 21 (0.42%) | 296 (0.30%) | 1.57 | 0.986–2.509 | 0.057 | 1.5 | 0.939–2.397 | 0.09 |
Breast cancer | 43 (0.87%) | 646 (0.66%) | 1.33 | 0.962–1.825 | 0.085 | 1.15 | 0.831–1.581 | 0.405 |
Colon cancer | 20 (0.40%) | 245 (0.25%) | 1.45 | 0.874–2.411 | 0.1501 | 1.33 | 0.799–2.213 | 0.273 |
Total cancer | 437 (8.79%) | 6132 (6.26%) | 1.39 | 1.261–1.531 | <0.0001 | 1.31 | 1.192–1.449 | <0.0001 * |
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Han, K.-T.; Cho, G.J.; Kim, E.H. Evaluation of the Association between Gestational Diabetes Mellitus at First Pregnancy and Cancer within 10 Years Postpartum Using National Health Insurance Data in South Korea. Int. J. Environ. Res. Public Health 2018, 15, 2646. https://doi.org/10.3390/ijerph15122646
Han K-T, Cho GJ, Kim EH. Evaluation of the Association between Gestational Diabetes Mellitus at First Pregnancy and Cancer within 10 Years Postpartum Using National Health Insurance Data in South Korea. International Journal of Environmental Research and Public Health. 2018; 15(12):2646. https://doi.org/10.3390/ijerph15122646
Chicago/Turabian StyleHan, Kyu-Tae, Geum Joon Cho, and Eui Hyeok Kim. 2018. "Evaluation of the Association between Gestational Diabetes Mellitus at First Pregnancy and Cancer within 10 Years Postpartum Using National Health Insurance Data in South Korea" International Journal of Environmental Research and Public Health 15, no. 12: 2646. https://doi.org/10.3390/ijerph15122646