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Article

Initiation and Single Dispensing in Cardiovascular and Insulin Medications: Prevalence and Explanatory Factors

by
Carles Vilaplana-Carnerero
1,2,
Ignacio Aznar-Lou
1,3,
María Teresa Peñarrubia-María
3,4,5,
Antoni Serrano-Blanco
3,6,
Rita Fernández-Vergel
4,5,
Dolors Petitbò-Antúnez
5,
Montserrat Gil-Girbau
1,2,7,
Marian March-Pujol
2,3,
Juan Manuel Mendive
4,5,7,
Alba Sánchez-Viñas
1,
Cristina Carbonell-Duacastella
1,3 and
Maria Rubio-Valera
3,6,*
1
Research and Development Unit, Institut de Recerca Sant Joan de Déu, 08830 Barcelona, Catalonia, Spain
2
School of Pharmacy, University of Barcelona, 08028 Barcelona, Catalonia, Spain
3
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública—CIBERESP), 28029 Madrid, Spain
4
Primary Care Research Institute (IDIAP Jordi Gol), 08007 Barcelona, Spain
5
Catalan Institute of Health, 08028 Barcelona, Spain
6
Parc Sanitari Sant Joan de Déu, 08830 Sant Boi de Llobregat, Catalonia, Spain
7
Primary Care Prevention and Health Promotion Research Network, 08007 Barcelona, Catalonia, Spain
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(10), 3358; https://doi.org/10.3390/ijerph17103358
Submission received: 15 April 2020 / Revised: 8 May 2020 / Accepted: 10 May 2020 / Published: 12 May 2020
(This article belongs to the Special Issue Real World Data (RWD) and Real World Evidence (RWE) in Health Care Decisions)
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Abstract

Background: Adherence problems have negative effects on health, but there is little information on the magnitude of non-initiation and single dispensing. Objective: The aim of this study was to estimate the prevalence of non-initiation and single dispensation and identify associated predictive factors for the main treatments prescribed in Primary Care (PC) for cardiovascular disease (CVD) and diabetes. Methods: Cohort study with real-world data. Patients who received a first prescription (2013–2014) for insulins, platelet aggregation inhibitors, angiotensin-converting enzyme inhibitors (ACEI) or statins in Catalan PC were included. The prevalence of non-initiation and single dispensation was calculated. Factors that explained these behaviours were explored. Results: At three months, between 5.7% (ACEI) and 9.1% (antiplatelets) of patients did not initiate their treatment and between 10.6% (statins) and 18.4% (ACEI) filled a single prescription. Body mass index, previous CVD, place of origin and having a substitute prescriber, among others, influenced the risk of non-initiation and single dispensation. Conclusions: The prevalence of non-initiation and single dispensation of CVD medications and insulin prescribed in PC in is high. Patient and health-system factors, such as place of origin and type of prescriber, should be taken into consideration when prescribing new medications for CVD and diabetes.
Keywords: cardiovascular diseases; insulin; adherence; primary care; real-world data; medication initiation cardiovascular diseases; insulin; adherence; primary care; real-world data; medication initiation

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MDPI and ACS Style

Vilaplana-Carnerero, C.; Aznar-Lou, I.; Peñarrubia-María, M.T.; Serrano-Blanco, A.; Fernández-Vergel, R.; Petitbò-Antúnez, D.; Gil-Girbau, M.; March-Pujol, M.; Mendive, J.M.; Sánchez-Viñas, A.; et al. Initiation and Single Dispensing in Cardiovascular and Insulin Medications: Prevalence and Explanatory Factors. Int. J. Environ. Res. Public Health 2020, 17, 3358. https://doi.org/10.3390/ijerph17103358

AMA Style

Vilaplana-Carnerero C, Aznar-Lou I, Peñarrubia-María MT, Serrano-Blanco A, Fernández-Vergel R, Petitbò-Antúnez D, Gil-Girbau M, March-Pujol M, Mendive JM, Sánchez-Viñas A, et al. Initiation and Single Dispensing in Cardiovascular and Insulin Medications: Prevalence and Explanatory Factors. International Journal of Environmental Research and Public Health. 2020; 17(10):3358. https://doi.org/10.3390/ijerph17103358

Chicago/Turabian Style

Vilaplana-Carnerero, Carles, Ignacio Aznar-Lou, María Teresa Peñarrubia-María, Antoni Serrano-Blanco, Rita Fernández-Vergel, Dolors Petitbò-Antúnez, Montserrat Gil-Girbau, Marian March-Pujol, Juan Manuel Mendive, Alba Sánchez-Viñas, and et al. 2020. "Initiation and Single Dispensing in Cardiovascular and Insulin Medications: Prevalence and Explanatory Factors" International Journal of Environmental Research and Public Health 17, no. 10: 3358. https://doi.org/10.3390/ijerph17103358

APA Style

Vilaplana-Carnerero, C., Aznar-Lou, I., Peñarrubia-María, M. T., Serrano-Blanco, A., Fernández-Vergel, R., Petitbò-Antúnez, D., Gil-Girbau, M., March-Pujol, M., Mendive, J. M., Sánchez-Viñas, A., Carbonell-Duacastella, C., & Rubio-Valera, M. (2020). Initiation and Single Dispensing in Cardiovascular and Insulin Medications: Prevalence and Explanatory Factors. International Journal of Environmental Research and Public Health, 17(10), 3358. https://doi.org/10.3390/ijerph17103358

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