Midregional Proadrenomedullin Can Reflect the Accumulation of Visceral Adipose Tissue—A Key to Explaining the Obesity Paradox
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Clinical and Biochemical Analysis
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Men | Women | ||||
---|---|---|---|---|---|
n = 727 | n = 1517 | ||||
Mean | SD | Mean | SD | p-Value | |
Age (years) | 59.7 | 10.3 | 57.1 | 9.92 | <0.001 |
BMI (kg/m2) | 23.5 | 2.98 | 21.6 | 3.18 | <0.001 |
VAT (cm2) | 79.9 | 36.0 | 51.3 | 26.6 | <0.001 |
SAT (cm2) | 145 | 50.9 | 130 | 66.4 | <0.001 |
VAT/SAT ratio | 0.552 | 0.187 | 0.427 | 0.182 | <0.001 |
BFM (%) | 23.6 | 4.38 | 30.36 | 4.69 | <0.001 |
SMM (%) | 30.1 | 2.28 | 24.94 | 6.24 | 0.300 |
METs (hours/day) | 14.8 | 11.0 | 15.4 | 10.4 | 0.248 |
Brinkman index | 513 | 557 | 69 | 186 | <0.001 |
Alcohol (g/day) | 22.5 | 28.1 | 6.63 | 13.3 | <0.001 |
Sleep time (hours) | 6.48 | 1.03 | 6.37 | 1.00 | 0.016 |
MR-proADM (nmol/L) | 0.467 | 0.099 | 0.412 | 0.082 | <0.001 |
n | % | n | % | ||
Hypertension | 364 | 50.1 | 440 | 29.0 | <0.001 |
Dyslipidemia | 322 | 44.3 | 675 | 44.5 | 0.482 |
Diabetes | 74 | 10.2 | 49 | 3.2 | <0.001 |
Men | Women | |||
---|---|---|---|---|
Coefficient | p-Value | Coefficient | p-Value | |
BMI | 0.130 | <0.001 | 0.304 | <0.001 |
VAT | 0.277 | <0.001 | 0.365 | <0.001 |
SAT | 0.161 | <0.001 | 0.333 | <0.001 |
VAT/SAT ratio | 0.225 | <0.001 | 0.062 | 0.015 |
BFM | 0.336 | <0.001 | 0.435 | <0.001 |
SMM | −0.485 | <0.001 | −0.413 | <0.001 |
Men | Women | |||||||
---|---|---|---|---|---|---|---|---|
Stepwise | Stepwise | |||||||
Beta | p-Value | Beta | p-Value | Beta | p-Value | Beta | p-Value | |
Age | 0.357 | <0.001 | 0.415 | <0.001 | 0.314 | <0.001 | 0.278 | <0.001 |
Hypertension | 0.081 | 0.020 | 0.086 | <0.001 | 0.086 | <0.001 | ||
Dyslipidemia | −0.008 | 0.804 | −0.021 | 0.387 | ||||
Diabetes | 0.019 | 0.566 | 0.015 | 0.490 | ||||
Sleep time | −0.019 | 0.564 | 0.020 | 0.375 | ||||
Alcohol | 0.124 | <0.001 | 0.124 | <0.001 | 0.098 | <0.001 | 0.110 | <0.001 |
Brinkman index | 0.028 | 0.419 | 0.010 | 0.676 | ||||
METs | −0.045 | 0.160 | −0.062 | 0.005 | ||||
BMI | −0.058 | 0.349 | 0.048 | 0.340 | ||||
BFM | 0.080 | 0.381 | −0.039 | 0.608 | 0.181 | <0.001 | ||
SMM | −0.052 | 0.533 | −0.061 | 0.262 | ||||
VAT | 0.130 | 0.326 | 0.184 | <0.001 | 0.173 | 0.003 | 0.203 | <0.001 |
SAT | 0.009 | 0.936 | 0.138 | 0.016 | ||||
VAT/SAT ratio | 0.011 | 0.902 | −0.027 | 0.551 |
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Koyama, T.; Kuriyama, N.; Uehara, R. Midregional Proadrenomedullin Can Reflect the Accumulation of Visceral Adipose Tissue—A Key to Explaining the Obesity Paradox. Int. J. Environ. Res. Public Health 2020, 17, 3968. https://doi.org/10.3390/ijerph17113968
Koyama T, Kuriyama N, Uehara R. Midregional Proadrenomedullin Can Reflect the Accumulation of Visceral Adipose Tissue—A Key to Explaining the Obesity Paradox. International Journal of Environmental Research and Public Health. 2020; 17(11):3968. https://doi.org/10.3390/ijerph17113968
Chicago/Turabian StyleKoyama, Teruhide, Nagato Kuriyama, and Ritei Uehara. 2020. "Midregional Proadrenomedullin Can Reflect the Accumulation of Visceral Adipose Tissue—A Key to Explaining the Obesity Paradox" International Journal of Environmental Research and Public Health 17, no. 11: 3968. https://doi.org/10.3390/ijerph17113968
APA StyleKoyama, T., Kuriyama, N., & Uehara, R. (2020). Midregional Proadrenomedullin Can Reflect the Accumulation of Visceral Adipose Tissue—A Key to Explaining the Obesity Paradox. International Journal of Environmental Research and Public Health, 17(11), 3968. https://doi.org/10.3390/ijerph17113968