Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Population
2.2. Residential Address History
2.3. Outcomes
2.4. Exposure Assessment
2.4.1. Air Pollution
2.4.2. Greenness
2.5. Time Windows for Exposures
2.6. Covariates and Mediators
2.7. Statistical Analyses
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Characteristics a | RHINESSA | |
---|---|---|
Fathers | Mothers | |
N (%) | N (%) | |
N | 400 (36.2) | 706 (63.8) |
Umea | 88 (22.0) | 166 (23.5) |
Uppsala | 85 (21.3) | 136 (19.3) |
Gothenburg | 58 (14.5) | 93 (13.1) |
Bergen | 169 (42.2) | 311 (44.1) |
Offspring sex (male) | 327 (48.2) | 630 (49.6) |
Offspring mean age (SD) | 5.4 (3.6) | 6.1 (4.2) |
Offspring early-onset asthma (<10 years of age) | 60 (15.0) | 141 (20.0) |
Offspring hay fever | 27 (6.8) | 70 (9.9) |
Parental mean age (SD) | 35.0 (3.8) | 34.6 (3.9) |
Parental asthma | 62 (15.5) | 128 (18.1) |
Early-onset asthma | 31 (7.8) | 35 (5.0) |
Late-onset asthma | 28 (7.0) | 88 (12.5) |
Parental hay fever | 125 (31.3) | 193 (27.3) |
Parental smoking onset | ||
Never-smokers | 271 (67.8) | 427 (60.5) |
Smokers before 18 years old | 103 (25.8) | 246 (34.8) |
Smokers after 18 years old | 26 (6.5) | 31 (4.4) |
Parental education | ||
Primary school | 9 (2.3) | 22 (3.1) |
Secondary school | 137 (34.3) | 185 (26.2) |
College/university | 253 (63.3) | 498 (70.5) |
Grandparental asthma | 45 (11.3) | 74 (10.5) |
(a) Early-Onset Asthma. | |||||||||
Univariable | Multivariable 3 | Univariable | Multivariable 3 | ||||||
Exposure 1 | Exposure Level 2 | Fathers (OR, 95% CI) | p4 | Fathers (OR, 95% CI) | p4 | Mothers (OR, 95% CI) | p4 | Mothers (OR, 95% CI) | p4 |
NO2 | Medium | 1.15 (0.58–2.30) | 0.690 | 1.09 (0.51–2.32) | 0.824 | 1.69 (1.05–2.73) | 0.032 | 1.78 (0.96–3.31) | 0.067 |
High | 0.70 (0.34–1.44) | 0.332 | 0.50 (0.21–1.20) | 0.120 | 1.68 (1.04–2.72) | 0.034 | 1.79 (0.89–3.60) | 0.101 | |
PM2.5 | Medium | 0.56 (0.27–1.14) | 0.111 | 0.48 (0.20–1.14) | 0.098 | 2.09 (1.30–3.37) | 0.002 | 2.23 (1.32–3.78) | 0.003 |
High | 0.70 (0.35–1.41) | 0.320 | 0.53 (0.24–1.17) | 0.115 | 1.55 (0.94–2.57) | 0.088 | 1.66 (0.96–2.88) | 0.072 | |
PM10 | Medium | 0.49 (0.23–1.04) | 0.064 | 0.46 (0.20–1.09) | 0.077 | 2.13 (1.35–3.38) | 0.001 | 2.27 (1.36–3.80) | 0.002 |
High | 0.82 (0.42–1.62) | 0.567 | 0.65 (0.31–1.40) | 0.273 | 1.39 (0.83–2.31) | 0.209 | 1.46 (0.84–2.53) | 0.183 | |
BC | Medium | 1.26 (0.64–2.46) | 0.501 | 0.86 (0.40–1.87) | 0.707 | 1.60 (1.00–2.58) | 0.051 | 1.45 (0.83–2.54) | 0.186 |
High | 0.48 (0.22–1.04) | 0.064 | 0.31 (0.11–0.87) | 0.026 | 1.57 (0.98–2.53) | 0.060 | 1.33 (0.69–2.58) | 0.393 | |
O3 | Medium | 1.90 (0.95–3.80) | 0.071 | 1.93 (0.93–4.01) | 0.079 | 0.81 (0.52–1.27) | 0.366 | 0.86 (0.53–1.39) | 0.542 |
High | 1.25 (0.60–2.60) | 0.550 | 1.09 (0.42–2.82) | 0.852 | 0.67 (0.42–1.06) | 0.084 | 0.97 (0.52–1.82) | 0.923 | |
NDVI (300 m) | Medium | 0.65 (0.30–1.42) | 0.279 | 0.56 (0.26–1.20) | 0.138 | 1.17 (0.74–1.85) | 0.505 | 1.25 (0.79–2.00) | 0.341 |
High | 0.76 (0.39–1.47) | 0.411 | 0.67 (0.31–1.42) | 0.297 | 0.78 (0.46–1.31) | 0.341 | 1.00 (0.59–1.72) | 0.987 | |
(b) Hay Fever. | |||||||||
Univariable | Multivariable 3 | Univariable | Multivariable 3 | ||||||
Exposure 1 | Exposure Level 2 | Fathers (OR, 95% CI) | p4 | Fathers (OR, 95% CI) | p4 | Mothers (OR, 95% CI) | p4 | Mothers (OR, 95% CI) | p4 |
NO2 | Medium | 1.67 (0.65–4.26) | 0.285 | 2.72 (0.82–9.02) | 0.103 | 1.13 (0.55–2.34) | 0.740 | 1.52 (0.51–4.56) | 0.454 |
High | 1.24 (0.45–3.40) | 0.680 | 2.41 (0.60–9.65) | 0.213 | 2.01 (1.04–3.90) | 0.039 | 2.84 (0.88–9.19) | 0.081 | |
PM2.5 | Medium | 1.46 (0.48–4.45) | 0.510 | 1.72 (0.44–6.80) | 0.438 | 1.69 (0.83–3.46) | 0.151 | 1.85 (0.85–4.00) | 0.121 |
High | 2.26 (0.75–6.85) | 0.149 | 2.78 (0.77–10.10) | 0.120 | 1.97 (0.99–3.91) | 0.052 | 1.90 (0.91–3.97) | 0.086 | |
PM10 | Medium | 1.24 (0.40–3.88) | 0.708 | 1.90 (0.46–7.87) | 0.375 | 1.71 (0.83–3.52) | 0.147 | 1.85 (0.85–4.01) | 0.121 |
High | 2.34 (0.78–7.00) | 0.127 | 3.41 (0.87–13.30) | 0.078 | 2.44 (1.26–4.72) | 0.008 | 2.66 (1.19–5.91) | 0.017 | |
BC | Medium | 2.10 (0.75–5.89) | 0.160 | 2.52 (0.81–7.88) | 0.112 | 1.50 (0.74–3.04) | 0.257 | 1.70 (0.70–4.16) | 0.243 |
High | 1.37 (0.46–4.05) | 0.575 | 2.56 (0.70–9.37) | 0.157 | 1.99 (1.00–3.97) | 0.052 | 2.71 (0.96–7.65) | 0.060 | |
O3 | Medium | 3.30 (1.16–9.40) | 0.025 | 4.15 (1.28–13.50) | 0.018 | 1.33 (0.70–2.52) | 0.383 | 1.56 (0.79–3.06) | 0.198 |
High | 1.91 (0.63–5.80) | 0.253 | 2.78 (0.58–13.26) | 0.199 | 0.84 (0.42–1.68) | 0.618 | 1.62 (0.54–4.82) | 0.389 | |
NDVI (300 m) | Medium | 0.80 (0.27–2.36) | 0.683 | 0.72 (0.24–2.14) | 0.551 | 1.18 (0.60–2.33) | 0.629 | 1.29 (0.65–2.57) | 0.460 |
High | 1.22 (0.48–3.13) | 0.681 | 1.35 (0.44–4.19) | 0.602 | 1.15 (0.58–2.30) | 0.683 | 1.57 (0.72–3.43) | 0.257 |
(a) Early-Onset Asthma. | ||||
Mediator | Parental exposure | Offspring Early-onset Asthma | ||
Total Effect | Indirect Effect | Direct Effect | ||
OR (95% CI) * | OR (95% CI) * | OR (95% CI) * | ||
Exposure during pregnancy (PM10) | PM10 (maternal) | |||
Low | 1.00 | 1.00 | 1.00 | |
Medium | 2.08 (1.31–3.31) | 1.10 (0.97–1.25) | 1.89 (1.17–3.06) | |
High | 1.36 (0.85–2.19) | 1.20 (0.96–1.50) | 1.13 (0.67–1.93) | |
(b) Hay Fever. | ||||
Mediator | Parental exposure | Offspring Hay Fever | ||
Total Effect | Indirect Effect | Direct Effect | ||
OR (95% CI) * | OR (95% CI) * | OR (95% CI) * | ||
Offspring own exposure (PM10) | PM10 (maternal) | |||
Low | 1.00 | 1.00 | 1.00 | |
Medium | 1.75 (0.75–4.04) | 1.24 (1.08–1.44) | 1.40 (0.60–3.27) | |
High | 2.70 (1.20–6.08) | 1.73 (1.25–2.39) | 1.56 (0.66–3.69) | |
Exposure during pregnancy (PM10) | PM10 (maternal) | |||
Low | 1.00 | 1.00 | 1.00 | |
Medium | 1.79 (0.79–4.08) | 1.49 (1.22–1.83) | 1.20 (0.52–2.74) | |
High | 2.71 (1.24–5.93) | 2.02 (1.49–2.76) | 1.34 (0.61–2.94) | |
Exposure during pregnancy (O3) | O3 (paternal) | |||
Low | 1.00 | 1.00 | 1.00 | |
Medium | 5.48 (1.50–20.1) | 1.10 (0.80–1.50) | 5.00 (1.31–19.1) | |
High | 4.14 (0.69–24.9) | 1.16 (0.70–1.94) | 3.55 (0.53–24.0) |
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Kuiper, I.N.; Markevych, I.; Accordini, S.; Bertelsen, R.J.; Bråbäck, L.; Christensen, J.H.; Forsberg, B.; Halvorsen, T.; Heinrich, J.; Hertel, O.; et al. Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever. Int. J. Environ. Res. Public Health 2020, 17, 5828. https://doi.org/10.3390/ijerph17165828
Kuiper IN, Markevych I, Accordini S, Bertelsen RJ, Bråbäck L, Christensen JH, Forsberg B, Halvorsen T, Heinrich J, Hertel O, et al. Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever. International Journal of Environmental Research and Public Health. 2020; 17(16):5828. https://doi.org/10.3390/ijerph17165828
Chicago/Turabian StyleKuiper, Ingrid Nordeide, Iana Markevych, Simone Accordini, Randi J. Bertelsen, Lennart Bråbäck, Jesper Heile Christensen, Bertil Forsberg, Thomas Halvorsen, Joachim Heinrich, Ole Hertel, and et al. 2020. "Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever" International Journal of Environmental Research and Public Health 17, no. 16: 5828. https://doi.org/10.3390/ijerph17165828
APA StyleKuiper, I. N., Markevych, I., Accordini, S., Bertelsen, R. J., Bråbäck, L., Christensen, J. H., Forsberg, B., Halvorsen, T., Heinrich, J., Hertel, O., Hoek, G., Holm, M., de Hoogh, K., Janson, C., Malinovschi, A., Marcon, A., Sigsgaard, T., Svanes, C., & Johannessen, A. (2020). Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever. International Journal of Environmental Research and Public Health, 17(16), 5828. https://doi.org/10.3390/ijerph17165828