Decompressive Craniectomy Improves QTc Interval in Traumatic Brain Injury Patients
Abstract
:1. Introduction
2. Methods
2.1. Patient Selection
2.2. Patients’ Monitoring and Management
2.3. Anaesthesia for Decompressive Craniectomy
2.4. Electrocardiography and Vectorcardiography Measurement, and Studied Time Points
2.5. Statistical Analysis
3. Results
4. Discussion
Limitations
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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n = 48 | R = 0.61, R2 = 0.37 Corrected R2 = 0.37 F(2.45) = 13.5, p < 0.001 | |||||
---|---|---|---|---|---|---|
b * | SD of b * | b | SD of b | t | p | |
5.99 | 0.366 | 16.343 | 0.0000 | |||
Heart rate | −0.633 | 0.123 | −0.02 | 0.004 | −5.131 | 0.0000 |
Dose of norepinephrine | 0.276 | 0.123 | 0.647 | 0.288 | 2.241 | 0.0300 |
Before DC | After DC | |
---|---|---|
I | 0.01 | 0 |
[−0.01; 0.02] | [−0.01; 0.02] | |
II | 0 | 0.02 * |
[−0.03; 0.02] | [−0.01; 0.04] | |
III | 0 | 0.01 ** |
[−0.02; 0.01] | [−0.01; 0.03] | |
aVR | 0 | −0.01 |
[−0.03; 0.02] | [−0.03; 0.01] | |
aVL | 0 | 0 |
[−0.01; 0.01] | [−0.01; 0.01] | |
aVF | 0 | 0.01 ** |
[−0.02; 0.02] | [−0.01; 0.04] | |
V1 | 0 | 0 |
[−0.01; 0.01] | [−0.01; 0.01] | |
V2 | 0 | 0 |
[−0.01; 0.02] | [−0.02; 0.02] | |
V3 | 0.01 | 0.01 |
[−0.01; 0.04] | [−0.02; 0.03] | |
V4 | −0.01 | −0.01 |
[−0.05; 0.03] | [−0.03; 0.03] | |
V5 | −0.01 | 0 |
[−0.03; 0.03] | [−0.02; 0.04] | |
V6 | 0 | 0.01 * |
[−0.02; 0.03] | [−0.01; 0.05] |
Lead | Time Point | Survivors | Non-Survivors | p Value |
---|---|---|---|---|
I | before DC | 0.01 | −0.01 | 0.005 |
[0; 0.02] | [−0.01; 0] | |||
after DC | 0.01 | −0.01 | 0.020 | |
[0; 0.02] | [−0.01; 0] | |||
II | before DC | 0.01 | −0.03 | 0.001 |
[−0.01; 0.04] | [−0.05; 0.01] | |||
after DC | 0.02 | −0.01 | 0.007 | |
0.01; 0.05] | [−0.04; 0.01] | |||
III | before DC | 0 | −0.01 | 0.016 |
[−0.01; 0.02] | [−0.04; 0] | |||
after DC | 0.01 | −0.01 | 0.025 | |
[0; 0.03] | [−0.03; 0.01] | |||
aVR | before DC | 0 | 0.03 | 0.006 |
[−0.04; 0.01] | [0; 0.05] | |||
after DC | −0.02 | 0 | 0.023 | |
[−0.03; 0] | [−0.01; 0.02] | |||
aVL | before DC | 0 | 0 | 0.533 |
[−0.01; 0.01] | [0; 0.01] | |||
after DC | 0 | 0.01 | 0.339 | |
[−0.01; 0.01] | [0; 0.01] | |||
aVF | before DC | 0.01 | −0.02 | 0.004 |
[−0.01; 0.03] | [−0.04; 0] | |||
after DC | 0.02 | −0.01 | 0.036 | |
[0.01; 0.04] | [−0.03; 0.02] | |||
V1 | before DC | −0.01 | 0.01 | 0.032 |
[−0.02; 0.02] | [0; 0.03] | |||
after DC | 0 | 0.01 | 0.115 | |
[−0.01; 0.02] | [0; 0.03] | |||
V2 | before DC | 0 | 0 | 0.787 |
[−0.01; 0.02] | [−0.02; 0.03] | |||
after DC | 0 | 0.01 | 0.444 | |
[−0.02; 0.02] | [−0.01; 0.02] | |||
V3 | before DC | 0.01 | 0 | 0.166 |
[0; 0.04 | [−0.03; 0.02] | |||
after DC | 0.01 * | 0 | 0.390 | |
[−0.02; 0.03 | [−0.03; 0.03] | |||
V4 | before DC | 0 | −0.05 | 0.012 |
[−0.03; 0.04] | −0.09; 0.02] | |||
after DC | 0 | −0.03 | 0.139 | |
[−0.03; 0.03] | [−0.06; 0.01] | |||
V5 | before DC | 0.01 | −0.02 | 0.008 |
[−0.02; 0.04] | [−0.06; −0.01] | |||
after DC | 0.01 | −0.03 | 0.015 | |
[−0.01; 0.05] | [−0.05; 0] | |||
V6 | before DC | 0.01 | −0.01 | 0.008 |
[−0.01; 0.04] | [−0.04; 0.01] | |||
after DC | 0.02 | −0.02 | 0.003 | |
[0.01; 0.05] | [−0.04; 0] |
R = 0.64, R2 = 0.41 Corrected R2 = 0.38 F(2.3) = 11.2 p < 0.001 | |||||||
b * | SD of b * | b | SD of b | t | p | ||
survivors | 6.136 | 0.435 | 14.078 | 0.0000 | |||
Heart rate | −0.666 | 0.142 | −0.023 | 0.004 | −4.682 | 0.0000 | |
Dose of norepinephrine | 0.296 | 0.142 | 0.615 | 0.295 | 2.085 | 0.0451 | |
non-survivors | R = 0.63, R2 = 0.4 Corrected R2 = 0.28 F(2.1) = 3.4 p < 0.075 | ||||||
6.152 | 0.785 | 7.836 | 0.0000 | ||||
Heart rate | −0.655 | 0.253 | −0.019 | 0.008 | −2.588 | 0.027 | |
Dose of norepinephrine | 0.2323 | 0.2533 | 0.7631 | 0.8323 | 0.9168 | 0.3807 |
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Dabrowski, W.; Siwicka-Gieroba, D.; Robba, C.; Badenes, R.; Kotfis, K.; Schlegel, T.T.; Jaroszynski, A. Decompressive Craniectomy Improves QTc Interval in Traumatic Brain Injury Patients. Int. J. Environ. Res. Public Health 2020, 17, 8653. https://doi.org/10.3390/ijerph17228653
Dabrowski W, Siwicka-Gieroba D, Robba C, Badenes R, Kotfis K, Schlegel TT, Jaroszynski A. Decompressive Craniectomy Improves QTc Interval in Traumatic Brain Injury Patients. International Journal of Environmental Research and Public Health. 2020; 17(22):8653. https://doi.org/10.3390/ijerph17228653
Chicago/Turabian StyleDabrowski, Wojciech, Dorota Siwicka-Gieroba, Chiara Robba, Rafael Badenes, Katarzyna Kotfis, Todd T. Schlegel, and Andrzej Jaroszynski. 2020. "Decompressive Craniectomy Improves QTc Interval in Traumatic Brain Injury Patients" International Journal of Environmental Research and Public Health 17, no. 22: 8653. https://doi.org/10.3390/ijerph17228653