Comorbidities and Cofactors of Anaphylaxis in Patients with Moderate to Severe Anaphylaxis. Analysis of Data from the Anaphylaxis Registry for West Pomerania Province, Poland
Abstract
:1. Introduction
- Non-modifiable/stable/independent/intrinsic
- Modifiable/unstable/dependent/extrinsic
2. Objective
3. Material and Methods
3.1. Study Design and Data Collection
3.2. Statistical Analysis
4. Results
4.1. Demographic Data
4.2. Comorbidities
4.3. Tryptase
4.4. Drugs
5. Analysis of Results and Discussion
5.1. Additional Material
5.2. Limitations
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Appendix A
- Did Your Patients, after contact with any factor, or spontaneously experience: difficulty breathing, wheezing, hypotension, cramping abdominal pain, diarrhea, vomiting, loss of consciousness? If so, complete the data
- Year of the patient’ birth
- Date of anaphylaxis onset
- Place of reaction
- Gender
- Mark the organ systems involved
- 6.1.
- Cutaneous: angioedema, flush, generalized erythema, generalized itching, generalized urticaria
- 6.2.
- Respiratory: apnoea, dyspnoea, stridor
- 6.3.
- Gastrointestinal: abdominal pain, diarrhoea, nausea, vomiting, incontinence
- 6.4.
- Cardiovascular: loss of consciousness, drop in blood pressure, collapse, cardiac arrest, dizziness, tachycardia, disorientation
- Mark the diagnostic tests usedMedical Interview, skin tests, sIgE, tryptase, provocation, other
- Was the reaction the first time?
- Is the trigger factor known?—is the identified trigger of anaphylaxis?Is this medicine? substanceIs this food? which oneIs this venom? which oneOther
- Prevention
- Please write other important details about this episode
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WAO [3] | A serious life-threatening generalized or systemic hypersensitivity reaction. A serious allergic reaction that is rapid in onset and might cause death |
EAACI [4] | A severe life-threatening generalized or systemic hypersensitivity reaction. An acute, potentially fatal, multi-organ system, allergic reaction. |
AAAAI/ACAAI [5] | An acute life-threatening systemic reaction with varied mechanisms, clinical presentations, and severity that results from the sudden release of mediators from mast cells and basophils. |
ASCIA [6] | Anaphylaxis is a serious, rapid-onset, allergic reaction that may cause death. Severe anaphylaxis is characterized by life-threatening upper airway obstruction, bronchospasm and/or hypotension. |
Classification by Ring and Messmer | |
---|---|
Grade I | Generalized skin symptoms (e.g., flush, generalized urticaria, angioedema) |
Grade II | Mild to moderate pulmonary, cardiovascular, and/or gastrointestinal symptoms |
Grade III | Anaphylactic shock, loss of consciousness |
Grade IV | Cardiac arrest, apnea |
Age Range | n Patients | % of Whole Group n = 382 | % of Tested n = 148 | % of Age Group |
---|---|---|---|---|
0–18 | 0 | 0 | 0 | 0 |
19–40 | 1 | 0.26 | 0.68 | 0.79 |
41–60 | 11 | 2.88 | 7.43 | 6.88 |
>60 | 3 | 0.79 | 2.03 | 6.67 |
Total | 15 | 3.93 | 10.14 | 3.93 |
Allergen | Cofactor | Patient Age | Recurrence |
---|---|---|---|
Omega 5 gliadin | Exercise | 24 years | 8× |
Omega 5 gliadin | Exercise + asthma | 28 years | 5× |
Omega 5 gliadin | Exercise + asthma + alcohol | 28 years | 4× |
Omega 5 gliadin | Exercise | 27 years | 2× |
LPT | Exercise + asthma | 31 years | 4× |
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Poziomkowska-Gęsicka, I.; Kostrzewska, M.; Kurek, M. Comorbidities and Cofactors of Anaphylaxis in Patients with Moderate to Severe Anaphylaxis. Analysis of Data from the Anaphylaxis Registry for West Pomerania Province, Poland. Int. J. Environ. Res. Public Health 2021, 18, 333. https://doi.org/10.3390/ijerph18010333
Poziomkowska-Gęsicka I, Kostrzewska M, Kurek M. Comorbidities and Cofactors of Anaphylaxis in Patients with Moderate to Severe Anaphylaxis. Analysis of Data from the Anaphylaxis Registry for West Pomerania Province, Poland. International Journal of Environmental Research and Public Health. 2021; 18(1):333. https://doi.org/10.3390/ijerph18010333
Chicago/Turabian StylePoziomkowska-Gęsicka, Iwona, Magdalena Kostrzewska, and Michał Kurek. 2021. "Comorbidities and Cofactors of Anaphylaxis in Patients with Moderate to Severe Anaphylaxis. Analysis of Data from the Anaphylaxis Registry for West Pomerania Province, Poland" International Journal of Environmental Research and Public Health 18, no. 1: 333. https://doi.org/10.3390/ijerph18010333