Cognitive Neural Mechanism of Social Anxiety Disorder: A Meta-Analysis Based on fMRI Studies
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Selection
2.2. Data Extraction
2.3. Study Quality
2.4. ALE Meta-Analysis
3. Results
3.1. Study Selection
3.2. Characteristics of the Included Studies
3.3. Study Quality
3.4. Activation Likelihood Estimation
4. Discussion
4.1. Anterior Cingulate Cortex
4.2. Angular Gyrus/Supramarginal Gyrus
4.3. Cerebellar Slope/Fusiform Gyrus
4.4. Different Task Types Affect Activation Patterns in Brain Regions
4.5. Advantages and Limitations of This Study
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
References
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ID | Ref. ID | Study Year | Number of Participants SAD/Healthy Controls | Number of Extracted Coordinates (SAD Groups) Healthy Controls) | Extract Number of Coordinates (SAD Groups Healthy Controls) | Coordinate System | Task Type |
---|---|---|---|---|---|---|---|
1 | [13] | 2002 | 15/15 | 8 | 0 | Talairach | Emotional face |
2 | [14] | 2005 | 11/11 | 40 | 0 | Talairach | Emotional face |
3 | [15] | 2006 | 10/10 | 8 | 0 | Talairach | Emotional face |
4 | [16] | 2008 | 11/11 | 10 | 2 | MNI | Emotional face |
5 | [17] | 2009 | 8/7 | 2 | 0 | Talairach | Emotional face |
6 | [18] | 2010 | 12/12 | 12 | 1 | MNI | Emotional face |
7 | [19] | 2010 | 8/7 | 11 | 4 | Talairach | Emotional face |
8 | [20] | 2012 | 29/26 | 14 | 0 | MNI | Emotional face |
9 | [21] | 2012 | 18/18 | 19 | 6 | MNI | Emotional face |
10 | [6] | 2013 | 14/12 | 9 | 1 | MNI | Emotional face |
11 | [22] | 2013 | 27/27 | 0 | 11 | Talairach | Emotional face |
12 | [23] | 2014 | 23/24 | 0 | 1 | MNI | Emotional face |
13 | [10] | 2016 | 20/20 | 0 | 8 | MNI | Emotional face |
14 | [24] | 2017 | 12/13 | 9 | 0 | MNI | Emotional face |
15 | [25] | 2016 | 19/21 | 4 | 1 | MNI | Emotional face |
16 | [26] | 2009 | 27/27 | 20 | 27 | Talairach | Specific situations |
17 | [27] | 2009 | 15/17 | 14 | 26 | Talairach | Specific situations |
18 | [28] | 2009 | 11/11 | 5 | 0 | MNI | Specific situations |
19 | [29] | 2011 | 6/9 | 0 | 5 | MNI | Specific situations |
20 | [30] | 2013 | 20/20 | 2 | 6 | MNI | Specific situations |
21 | [31] | 2014 | 20/20 | 15 | 0 | Talairach | Specific situations |
22 | [32] | 2016 | 30/30 | 12 | 0 | Talairach | Specific situations |
23 | [33] | 2017 | 24/24 | 11 | 0 | Talairach | Specific situations |
24 | [7] | 2004 | 8/6 | 3 | 6 | Talairach | Speech task |
25 | [34] | 2014 | 17/17 | 2 | 1 | Talairach | Speech task |
26 | [35] | 2018 | 51/13 | 2 | 1 | MNI | Speech task |
27 | [36] | 2008 | 12/12 | 1 | 0 | Talairach | Listen to the words and recognize the emotional colors |
28 | [37] | 2010 | 16/16 | 5 | 0 | Talairach | Story reading |
29 | [38] | 2011 | 16/18 | 21 | 2 | Talairach | Emotional pictures |
30 | [39] | 2011 | 15/15 | 10 | 0 | Talairach | Discourse presentation |
31 | [40] | 2012 | 15/15 | 2 | 0 | MNI | Cognitive task |
32 | [41] | 2011 | 20/20 | 2 | 0 | Talairach | Security review awareness task |
33 | [42] | 2014 | 21/23 | 8 | 0 | MNI | Emotion regulation task |
34 | [43] | 2015 | 16/16 | 6 | 0 | Talairach | Emotion Stroop task |
35 | [44] | 2016 | 20/20 | 15 | 0 | MNI | Memory task |
36 | [45] | 2017 | 21/22 | 33 | 3 | MNI | Currency delayed |
37 | [46] | 2017 | 16/16 | 0 | 3 | Talairach | Time estimation task |
Total | 654/594 | 335 | 115 |
Central Coordinates | Volume mm3 | p–Value | Maximum ALE Value | Cerebral Area | |||
---|---|---|---|---|---|---|---|
X | Y | Z | |||||
Global analysis | −6 | 22 | 38 | 584 | 0.000124 | 0.015 | Anterior cingulate gyrus |
Emotional face task | −26 | −68 | −12 | 496 | 0.00000034 | 0.015 | Cerebellar slope, fusiform gyrus |
Situational task | 58 | −52 | 30 | 784 | 0.0000046 | 0.013 | Supramarginal gyrus and angular gyrus |
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Yu, X.; Ruan, Y.; Zhang, Y.; Wang, J.; Liu, Y.; Zhang, J.; Zhang, L. Cognitive Neural Mechanism of Social Anxiety Disorder: A Meta-Analysis Based on fMRI Studies. Int. J. Environ. Res. Public Health 2021, 18, 5556. https://doi.org/10.3390/ijerph18115556
Yu X, Ruan Y, Zhang Y, Wang J, Liu Y, Zhang J, Zhang L. Cognitive Neural Mechanism of Social Anxiety Disorder: A Meta-Analysis Based on fMRI Studies. International Journal of Environmental Research and Public Health. 2021; 18(11):5556. https://doi.org/10.3390/ijerph18115556
Chicago/Turabian StyleYu, Xianglian, Yijun Ruan, Yawen Zhang, Jiayi Wang, Yuting Liu, Jibiao Zhang, and Lin Zhang. 2021. "Cognitive Neural Mechanism of Social Anxiety Disorder: A Meta-Analysis Based on fMRI Studies" International Journal of Environmental Research and Public Health 18, no. 11: 5556. https://doi.org/10.3390/ijerph18115556