Next Article in Journal
The Experience of Clinical Nurses after Korea’s Enactment of Workplace Anti-Bullying Legislation: A Phenomenological Study
Next Article in Special Issue
Pregnancy and COVID-19 Pandemic Perception in Malaysia: A Cross-Sectional Study
Previous Article in Journal
Polycyclic Aromatic Hydrocarbon Levels in Wistar Rats Exposed to Ambient Air of Port Harcourt, Nigeria: An Indicator for Tissue Toxicity
Previous Article in Special Issue
Disposal Behavior of Used Masks during the COVID-19 Pandemic in the Moroccan Community: Potential Environmental Impact
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJERPH
Volume 18
Issue 11
10.3390/ijerph18115709
ijerph-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Pregnancy Outcome, Antibodies, and Placental Pathology in SARS-CoV-2 Infection during Early Pregnancy

by
Won-Kyu Jang
1,
Su-Yeon Lee
1,
Sunggyun Park
2,
Nam Hee Ryoo
2,
Ilseon Hwang
3,
Ji Min Park
3 and
Jin-Gon Bae
1,*
1
Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea
2
Departments of Laboratory Medicine, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea
3
Department of Pathology, Keimyung University School of Medicine, Dongsan Medical Center, Daegu 42601, Korea
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(11), 5709; https://doi.org/10.3390/ijerph18115709
Submission received: 21 April 2021 / Revised: 17 May 2021 / Accepted: 25 May 2021 / Published: 26 May 2021
(This article belongs to the Collection COVID-19 Research)
Browse Figure
Review Reports Versions Notes

Abstract

There are reports that pregnant women infected with SARS-CoV-2 not only have increased morbidity but also increased complications and evidence of maternal and fetal vascular malperfusion on placental pathology. This was a retrospective study of pregnant women diagnosed with SARS-CoV-2 infection after March 2020. The results of reverse transcription polymerase chain reaction testing and IgM and IgG antibody testing of the amniotic fluid, cord blood, placenta, and maternal blood were confirmed at delivery. Placentas were evaluated histopathologically. The study included seven pregnant women diagnosed with SARS-CoV-2 infection during pregnancy at a mean gestational age of 14.5 weeks. Out of the seven women, five were infected during the first trimester. The mean gestational age at delivery was 38.4 weeks. The reverse transcription polymerase chain reaction results for maternal plasma, cord blood, placenta, and amniotic fluid were negative and IgG antibodies were detected in maternal plasma and cord blood. On placental pathology, maternal vascular malperfusion was found in only one case, fetal vascular malperfusion in four cases, and inflammatory changes were found in two cases. Pregnancy outcomes for women diagnosed with SARS-CoV-2 infection during early pregnancy are positive and it is likely that maternal antibodies are passed to the fetus, which results in a period of immunity.
Keywords: COVID-19; SARS-CoV-2; vertical infection transmission; COVID-19 antibody; neutralizing antibody; first trimester pregnancy; placenta; pathology COVID-19; SARS-CoV-2; vertical infection transmission; COVID-19 antibody; neutralizing antibody; first trimester pregnancy; placenta; pathology

Share and Cite

MDPI and ACS Style

Jang, W.-K.; Lee, S.-Y.; Park, S.; Ryoo, N.H.; Hwang, I.; Park, J.M.; Bae, J.-G. Pregnancy Outcome, Antibodies, and Placental Pathology in SARS-CoV-2 Infection during Early Pregnancy. Int. J. Environ. Res. Public Health 2021, 18, 5709. https://doi.org/10.3390/ijerph18115709

AMA Style

Jang W-K, Lee S-Y, Park S, Ryoo NH, Hwang I, Park JM, Bae J-G. Pregnancy Outcome, Antibodies, and Placental Pathology in SARS-CoV-2 Infection during Early Pregnancy. International Journal of Environmental Research and Public Health. 2021; 18(11):5709. https://doi.org/10.3390/ijerph18115709

Chicago/Turabian Style

Jang, Won-Kyu, Su-Yeon Lee, Sunggyun Park, Nam Hee Ryoo, Ilseon Hwang, Ji Min Park, and Jin-Gon Bae. 2021. "Pregnancy Outcome, Antibodies, and Placental Pathology in SARS-CoV-2 Infection during Early Pregnancy" International Journal of Environmental Research and Public Health 18, no. 11: 5709. https://doi.org/10.3390/ijerph18115709

APA Style

Jang, W.-K., Lee, S.-Y., Park, S., Ryoo, N. H., Hwang, I., Park, J. M., & Bae, J.-G. (2021). Pregnancy Outcome, Antibodies, and Placental Pathology in SARS-CoV-2 Infection during Early Pregnancy. International Journal of Environmental Research and Public Health, 18(11), 5709. https://doi.org/10.3390/ijerph18115709

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop