Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Ethics
2.2. Research Subjects and CSF Sampling
2.3. Statistical Analysis
3. Results
4. Discussion
Limitations and Strengths of the Study
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Mean (SD) | 2.5th Percentile | 97.5th Percentile | |
---|---|---|---|
CSF-TP (mg/dL) | |||
All participants (n = 69) | 41.7 (12.3) | 22.5 | 73.2 |
Male (n = 37) | 43.7 (12.5) | 24.4 | 72.5 |
Female (n = 32) | 39.4 (11.9) | 19.0 | 75.0 |
CSF-glucose (mg/dL) | |||
All participants (n = 69) | 59.9 (5.5) | 49.8 | 72.0 |
Male (n = 37) | 61.1 (5.1) | 49.2 | 72.8 |
Female (n = 32) | 58.6 (5.7) | 50.0 | 72.0 |
Age Group | 55–64, Year (n = 42) Mean (SD) | ≥65, Year (n = 27) Mean (SD) | p-Value a |
---|---|---|---|
CSF-TP (mg/dL) | 39.0 (10.5) | 45.9 (13.9) | 0.044 |
CSF-glucose (mg/dL) | 60.3 (6.1) | 59.4 (4.5) | 0.658 |
Historical Controls | Setting | Subject | Mean Age (Range), year | Number | Mean CSF-TP (SD), mg/dL | p-Value a |
---|---|---|---|---|---|---|
Hirohata et al. 1984 [12] | Japan | Patients with no neurological disease | 34.2 (13–57) | 30 | 29.9 (9.0) | <0.001 |
Breebaart et al. 1978 [16] | Netherlands | Patients with no neurological disease | 38 | 139 | 31 (18) | <0.001 |
Takeoka et al. 1976 [11] | Japan | Patients with no neurological disease | 41.0 (18–77) | 27 | 30.0 (6.9) | <0.001 |
Hegen et al. 2016 [3] | Austria | Patients with no neurological disease | 42.1 (18–80) | 332 | 40.2 (12.6) | 0.367 |
McCudden et al. 2017 [4] | Canada | Female patients with no neurological disease | 43 (18–97) | 3804 | 32 (10) | <0.001 |
Male patients with no neurological disease | 44 (18–94) | 2264 | 38 (11) | 0.006 | ||
Atack et al. 1988 [17] | USA | Healthy normal subjects | 48.1 (20–86) | 26 | 49 (10) | 0.069 |
Dufour-Rainfray et al. 2013 [6] | France | CSF samples with cellularity and high glucose levels were excluded | (50–100) | 1192 | 48 (24) | 0.031 |
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Yoshihara, T.; Zaitsu, M.; Ito, K.; Hanada, R.; Chung, E.; Yazawa, R.; Sakata, Y.; Furusho, K.; Tsukikawa, H.; Chiyoda, T.; et al. Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers. Int. J. Environ. Res. Public Health 2021, 18, 8683. https://doi.org/10.3390/ijerph18168683
Yoshihara T, Zaitsu M, Ito K, Hanada R, Chung E, Yazawa R, Sakata Y, Furusho K, Tsukikawa H, Chiyoda T, et al. Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers. International Journal of Environmental Research and Public Health. 2021; 18(16):8683. https://doi.org/10.3390/ijerph18168683
Chicago/Turabian StyleYoshihara, Tatsuya, Masayoshi Zaitsu, Kazuya Ito, Ryuzo Hanada, Eunhee Chung, Rie Yazawa, Yukikuni Sakata, Koki Furusho, Hiroshi Tsukikawa, Takeshi Chiyoda, and et al. 2021. "Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers" International Journal of Environmental Research and Public Health 18, no. 16: 8683. https://doi.org/10.3390/ijerph18168683