The Mediation Effects of Aluminum in Plasma and Dipeptidyl Peptidase Like Protein 6 (DPP6) Polymorphism on Renal Function via Genome-Wide Typing Association
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population
2.2. Questionnaires
2.3. Laboratory Analysis
2.4. Genotyping
2.5. Statistical Analysis
2.5.1. Descriptive Analysis
2.5.2. Genome-Wide Association (GWA)
2.5.3. Mediation Analysis
3. Results
3.1. Study Population and SNPs Typing
3.2. Characteristics of Study Population
3.3. Association between eGFR and Al
3.4. Genome-Wide Association Test
3.5. Mediation Analysis
3.5.1. rs10224371→ln(Al)→eGFR
3.5.2. rs2316242→ln(Al)→eGFR
3.5.3. rs10268004→ln(Al)→eGFR
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Ethics Information
References
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Term (n = 494) | Mean ± SD, N(%) | Min | Q1 | Q2 | Q3 | Max |
---|---|---|---|---|---|---|
Gender (Male) | 275(55.7%) | |||||
Drink (Current drinking) a | 39(7.9%) | |||||
Smoke experience (Yes) | 169(34.2%) | |||||
Age (year) | 48.3 ± 10.9 | 30 | 40 | 47 | 54 | 70 |
Height (cm) | 165.18 ± 8.63 | 142.0 | 188.5 | 158.5 | 165.5 | 171.5 |
Weight (kg) | 66.95 ± 12.32 | 39.4 | 120.8 | 58.2 | 66.80 | 74.8 |
γ-GT (U/L) | 26.25 ± 27.09 | 6.0 | 13.0 | 18.0 | 30.0 | 293.0 |
BUN (mg/dL) | 13.06 ± 3.48 | 5.0 | 10.6 | 12.6 | 15.2 | 28.2 |
Creatinine (mg/dL) | 0.78 ± 0.19 | 0.33 | 0.62 | 0.79 | 0.91 | 1.50 |
eGFR b (mL/min/1.73 m2) | 99.52 ± 22.00 | 49.15 | 85.30 | 96.99 | 110.37 | 216.66 |
Uric acid (mg/dL) | 5.73 ± 1.56 | 2.6 | 4.5 | 5.6 | 6.9 | 12.4 |
HbA1C (%) | 5.66 ± 0.55 | 4.4 | 5.4 | 5.6 | 5.8 | 11.9 |
Total cholesterol (mg/dL) | 197.7 ± 35.8 | 117 | 358 | 174 | 195 | 217 |
TG (mg/dL) | 122.9 ± 85.7 | 30 | 798 | 68 | 101 | 145 |
HDL (mg/dL) | 53.8 ± 13.2 | 26 | 108 | 44 | 52 | 62 |
LDL (mg/dL) | 125.5 ± 32.4 | 47 | 258 | 105 | 124 | 146 |
AST (U/L) | 23.38 ± 11.44 | 10 | 18 | 21 | 26 | 167 |
ALT (U/L) | 25.6 ± 23.4 | 7 | 15 | 20 | 28 | 344 |
Aluminum (μg/L) | 1.13 ± 0.80 | 0.29 | 0.78 | 0.99 | 1.27 | 13.94 |
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Chen, T.-H.; Yang, C.-C.; Luo, K.-H.; Dai, C.-Y.; Chuang, Y.-C.; Chuang, H.-Y. The Mediation Effects of Aluminum in Plasma and Dipeptidyl Peptidase Like Protein 6 (DPP6) Polymorphism on Renal Function via Genome-Wide Typing Association. Int. J. Environ. Res. Public Health 2021, 18, 10484. https://doi.org/10.3390/ijerph181910484
Chen T-H, Yang C-C, Luo K-H, Dai C-Y, Chuang Y-C, Chuang H-Y. The Mediation Effects of Aluminum in Plasma and Dipeptidyl Peptidase Like Protein 6 (DPP6) Polymorphism on Renal Function via Genome-Wide Typing Association. International Journal of Environmental Research and Public Health. 2021; 18(19):10484. https://doi.org/10.3390/ijerph181910484
Chicago/Turabian StyleChen, Ting-Hao, Chen-Cheng Yang, Kuei-Hau Luo, Chia-Yen Dai, Yao-Chung Chuang, and Hung-Yi Chuang. 2021. "The Mediation Effects of Aluminum in Plasma and Dipeptidyl Peptidase Like Protein 6 (DPP6) Polymorphism on Renal Function via Genome-Wide Typing Association" International Journal of Environmental Research and Public Health 18, no. 19: 10484. https://doi.org/10.3390/ijerph181910484