Effect of Obstructive Sleep Apnea on the Risk of Injuries—A Nationwide Population-Based Cohort Study

Cheng, An-Che; Wu, Gwo-Jang; Chung, Chi-Hsiang; Wu, Kuo-Hsiang; Sun, Chien-An; Wang, I-Duo; Chien, Wu-Chien

doi:10.3390/ijerph182413416

Open AccessArticle

Effect of Obstructive Sleep Apnea on the Risk of Injuries—A Nationwide Population-Based Cohort Study

by

An-Che Cheng

¹,

Gwo-Jang Wu

^2,3,

Chi-Hsiang Chung

^4,5,6,

Kuo-Hsiang Wu

⁷,

Chien-An Sun

^8,9

,

I-Duo Wang

^10,* and

Wu-Chien Chien

^4,5,6,11,*

¹

Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan

²

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei City 11490, Taiwan

³

Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan

⁴

School of Public Health, National Defense Medical Center, Taipei City 11490, Taiwan

⁵

Department of Medical Research, Tri-Service General Hospital, Taipei City 11490, Taiwan

⁶

Taiwanese Injury Prevention and Safety Promotion Association (TIPSPA), Taipei City 11490, Taiwan

⁷

Department of Nursing, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan

⁸

Big Data Research Center, College of Medicine, Fu-Jen Catholic University, New Taipei City 24205, Taiwan

⁹

Department of Public Health, College of Medicine, Fu-Jen Catholic University, New Taipei City 24205, Taiwan

¹⁰

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan

¹¹

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei City 11490, Taiwan

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Int. J. Environ. Res. Public Health 2021, 18(24), 13416; https://doi.org/10.3390/ijerph182413416

Submission received: 12 November 2021 / Revised: 8 December 2021 / Accepted: 10 December 2021 / Published: 20 December 2021

(This article belongs to the Special Issue Big Data for Public Health Research and Practice)

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Abstract

Obstructive sleep apnea (OSA) has been reported to increase the risk of motor vehicle accidents. However, only few studies have investigated the effects of OSA on overall risk injury. The aim of study is to investigate whether OSA increases the risk of overall injury. The data were collected during 2000–2015 from Taiwan’s National Health Insurance Research Database. A total of 8901 individuals diagnosed with OSA were inpatients, or outpatients at least three times were enrolled. Finally, 6915 participants with OSA were included as the study cohort. We matched the study cohort with a comparison cohort, at a ratio of 1:4. Cox proportional hazards regression was used to analyse the association between OSA and overall injury. Patients with OSA had 83.1% increased risk of overall injury, compared to non-OSA individuals [adjusted hazards ratio (HR) = 1.831, confidence interval (CI) = 1.674–2.020, p < 0.001]. In the stratified age group, patients aged ≧65 years had the highest risk of injury (adjusted HR= 2.014; CI = 1.842–2.222, p < 0.001). Patients with OSA were at a higher risk of falls, traffic injury, poisoning, suffocation, suicide, and abuse or homicide than non-OSA individuals, with falls and traffic injury as the leading causes of injuries. The data demonstrated that patients with OSA have a higher risk of overall injury. The study results can be a reference for developing injury prevention strategies in the future. The general population and clinicians should have more awareness regarding OSA and its negative effects on injury development.

Keywords: obstructive sleep apnoea; injuries; Taiwan national healths insurance research database; longitudinal health insurance database

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MDPI and ACS Style

Cheng, A.-C.; Wu, G.-J.; Chung, C.-H.; Wu, K.-H.; Sun, C.-A.; Wang, I.-D.; Chien, W.-C. Effect of Obstructive Sleep Apnea on the Risk of Injuries—A Nationwide Population-Based Cohort Study. Int. J. Environ. Res. Public Health 2021, 18, 13416. https://doi.org/10.3390/ijerph182413416

AMA Style

Cheng A-C, Wu G-J, Chung C-H, Wu K-H, Sun C-A, Wang I-D, Chien W-C. Effect of Obstructive Sleep Apnea on the Risk of Injuries—A Nationwide Population-Based Cohort Study. International Journal of Environmental Research and Public Health. 2021; 18(24):13416. https://doi.org/10.3390/ijerph182413416

Chicago/Turabian Style

Cheng, An-Che, Gwo-Jang Wu, Chi-Hsiang Chung, Kuo-Hsiang Wu, Chien-An Sun, I-Duo Wang, and Wu-Chien Chien. 2021. "Effect of Obstructive Sleep Apnea on the Risk of Injuries—A Nationwide Population-Based Cohort Study" International Journal of Environmental Research and Public Health 18, no. 24: 13416. https://doi.org/10.3390/ijerph182413416

APA Style

Cheng, A.-C., Wu, G.-J., Chung, C.-H., Wu, K.-H., Sun, C.-A., Wang, I.-D., & Chien, W.-C. (2021). Effect of Obstructive Sleep Apnea on the Risk of Injuries—A Nationwide Population-Based Cohort Study. International Journal of Environmental Research and Public Health, 18(24), 13416. https://doi.org/10.3390/ijerph182413416

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Effect of Obstructive Sleep Apnea on the Risk of Injuries—A Nationwide Population-Based Cohort Study

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