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Volume 18
Issue 7
10.3390/ijerph18073372
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Article

Diagnostic Value of IgM and IgG Detection in COVID-19 Diagnosis by the Mobile Laboratory B-LiFE: A Massive Testing Strategy in the Piedmont Region

by
Omar Nyabi
1,*,
Mostafa Bentahir
1,
Jérôme Ambroise
1,
Bertrand Bearzatto
1,
Nawfal Chibani
1,
Benjamin Smits
1,
Jean François Durant
1,
Aleksandr Vybornov
1,
Olivier Thellin
2,
Benaissa El Moualij
2 and
Jean-Luc Gala
1
1
Center for Applied Molecular Technologies (CTMA), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, 1348 Woluwe saint-Lambert, Belgium
2
Centre de Recherche sur les Protéines Prions (CRPP) ULiège, Quartier Hôpital, 15, Avenue Hippocrate, B 4000 Liège, Belgium
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2021, 18(7), 3372; https://doi.org/10.3390/ijerph18073372
Submission received: 23 February 2021 / Revised: 17 March 2021 / Accepted: 18 March 2021 / Published: 24 March 2021
(This article belongs to the Special Issue Emerging Biological Threats and Public Health Preparedness)
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Abstract

Coronavirus disease 2019 (COVID-19) is an acute infectious disease caused by the novel coronavirus (SARS-CoV-2) identified in 2019. The COVID-19 outbreak continues to have devastating consequences for human lives and the global economy. The B-LiFe mobile laboratory in Piedmont, Italy, was deployed for the surveillance of COVID-19 cases by large-scale testing of first responders. The objective was to assess the seroconversion among the regional civil protection (CP), police, health care professionals, and volunteers. The secondary objective was to detect asymptomatic individuals within this cohort in the light of age, sex, and residence. In this paper, we report the results of serological testing performed by the B-LiFe mobile laboratory deployed from 10 June to 23 July 2020. The tests included whole blood finger-prick and serum sampling for detection of SARS-CoV-2 spike receptor-binding domain (S-RBD) antibodies. The prevalence of SARS-CoV-2 antibodies was approximately 5% (294/6013). The results of the finger-prick tests and serum sample analyses showed moderate agreement (kappa = 0.77). Furthermore, the detection rates of serum antibodies to the SARS-CoV-2 nucleocapsid protein (NP) and S-RBD among the seroconverted individuals were positively correlated (kappa = 0.60), at least at the IgG level. Seroprevalence studies based on serological testing for the S-RBD protein or SARS-CoV-2 NP antibodies are not sufficient for diagnosis but might help in screening the population to be vaccinated and in determining the duration of seroconversion.
Keywords: SARS-CoV-2; Public Health Preparedness; emerging biological threats SARS-CoV-2; Public Health Preparedness; emerging biological threats

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MDPI and ACS Style

Nyabi, O.; Bentahir, M.; Ambroise, J.; Bearzatto, B.; Chibani, N.; Smits, B.; Durant, J.F.; Vybornov, A.; Thellin, O.; El Moualij, B.; et al. Diagnostic Value of IgM and IgG Detection in COVID-19 Diagnosis by the Mobile Laboratory B-LiFE: A Massive Testing Strategy in the Piedmont Region. Int. J. Environ. Res. Public Health 2021, 18, 3372. https://doi.org/10.3390/ijerph18073372

AMA Style

Nyabi O, Bentahir M, Ambroise J, Bearzatto B, Chibani N, Smits B, Durant JF, Vybornov A, Thellin O, El Moualij B, et al. Diagnostic Value of IgM and IgG Detection in COVID-19 Diagnosis by the Mobile Laboratory B-LiFE: A Massive Testing Strategy in the Piedmont Region. International Journal of Environmental Research and Public Health. 2021; 18(7):3372. https://doi.org/10.3390/ijerph18073372

Chicago/Turabian Style

Nyabi, Omar, Mostafa Bentahir, Jérôme Ambroise, Bertrand Bearzatto, Nawfal Chibani, Benjamin Smits, Jean François Durant, Aleksandr Vybornov, Olivier Thellin, Benaissa El Moualij, and et al. 2021. "Diagnostic Value of IgM and IgG Detection in COVID-19 Diagnosis by the Mobile Laboratory B-LiFE: A Massive Testing Strategy in the Piedmont Region" International Journal of Environmental Research and Public Health 18, no. 7: 3372. https://doi.org/10.3390/ijerph18073372

APA Style

Nyabi, O., Bentahir, M., Ambroise, J., Bearzatto, B., Chibani, N., Smits, B., Durant, J. F., Vybornov, A., Thellin, O., El Moualij, B., & Gala, J.-L. (2021). Diagnostic Value of IgM and IgG Detection in COVID-19 Diagnosis by the Mobile Laboratory B-LiFE: A Massive Testing Strategy in the Piedmont Region. International Journal of Environmental Research and Public Health, 18(7), 3372. https://doi.org/10.3390/ijerph18073372

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