Analysis of Patients with Alcohol Dependence Treated in Silesian Intensive Care Units
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Alcohol Dependent | Not Alcohol Dependent | p | ||||
---|---|---|---|---|---|---|
(n = 2285) | (n = 23,131) | |||||
Admission | First | 2189 | (95.8%) | 21,781 | (94.2%) | 0.002 |
Second | 92 | (4.0%) | 1176 | (5.1%) | 0.030 | |
Another | 4 | (0.2%) | 174 | (0.8%) | 0.002 | |
Co-morbidities | Coronary artery disease | 355 | (15.5%) | 10,137 | (43.8%) | <0.001 |
Heart failure | 344 | (15.1%) | 8500 | (36.7%) | <0.001 | |
Arterial hypertension | 626 | (27.4%) | 12,622 | (54.6%) | <0.001 | |
Disseminated atherosclerosis | 405 | (17.7%) | 8116 | (35.1%) | <0.001 | |
Chronic respiratory failure | 147 | (6.4%) | 3013 | (13.0%) | <0.001 | |
Home oxygen therapy | 3 | (0.1%) | 378 | (1.6%) | <0.001 | |
Extreme obesity | 39 | (1.7%) | 1417 | (6.1%) | <0.001 | |
Cachexia | 253 | (11.1%) | 648 | (2.8%) | <0.001 | |
Diabetes | 270 | (11.8%) | 6120 | (26.5%) | <0.001 | |
Chronic renal failure | 120 | (5.3%) | 3629 | (15.7%) | <0.001 | |
Dialysis dependency | 11 | (0.5%) | 310 | (1.3%) | 0.001 | |
Previous cerebral stroke | 78 | (3.4%) | 1824 | (7.9%) | <0.001 | |
Chronic neurological disorders | 219 | (9.6%) | 1736 | (7.5%) | <0.001 | |
Systemic autoimmune diseases | 4 | (0.2%) | 304 | (1.3%) | <0.001 | |
Post-transplant | 1 | (0.0%) | 73 | (0.3%) | 0.036 | |
Cancer | 27 | (1.2%) | 2095 | (9.1%) | <0.001 | |
Pregnancy | 0 | (0.0%) | 41 | (0.2%) | 0.082 | |
None | 0 | (0.0%) | 2413 | (10.4%) | <0.001 |
Variables | Alcohol Dependent | Not Alcohol Dependent | p | ||
---|---|---|---|---|---|
(n = 2285) | (n = 23,131) | ||||
Acute respiratory failure | 1722 | (75.4%) | 17,259 | (74.6%) | 0.448 |
Exacerbation of resp. failure | 82 | (3.6%) | 1975 | (8.5%) | <0.001 |
Exacerbation of circulatory failure | 857 | (37.5%) | 11,053 | (47.8%) | <0.001 |
Multiorgan failure | 373 | (16.3%) | 2929 | (12.7%) | <0.001 |
Shock | 676 | (29.6%) | 6961 | (30.1%) | 0.629 |
Cardiac arrest | 717 | (31.4%) | 5401 | (23.3%) | <0.001 |
Disorders of consciousness | 1185 | (51.9%) | 8866 | (38.3%) | <0.001 |
Postoperative | 285 | (12.5%) | 7516 | (32.5%) | <0.001 |
Multiple trauma | 117 | (5.1%) | 819 | (3.5%) | <0.001 |
Craniocerebral trauma | 287 | (12.6%) | 896 | (3.9%) | <0.001 |
Acute pancreatitis | 94 | (4.1%) | 293 | (1.3%) | <0.001 |
Obstetric complications | 0 | (0.0%) | 87 | (0.4%) | 0.006 |
Acute neurological disorders | 197 | (8.6%) | 1729 | (7.5%) | 0.053 |
Intoxication | 148 | (6.5%) | 225 | (1.0%) | <0.001 |
Severe metabolic disorders | 299 | (13.1%) | 1095 | (4.7%) | <0.001 |
Bacterial infection | 414 | (18.1%) | 4412 | (19.1%) | 0.279 |
Sepsis | 174 | (7.6%) | 1632 | (7.1%) | 0.342 |
Viral infection | 6 | (0.3%) | 115 | (0.5%) | 0.163 |
Variables | Alcohol Dependent | Not Alcohol Dependent | p | ||
---|---|---|---|---|---|
(n = 2285) | (n = 23,131) | ||||
Use of catecholamines | 1684 | (73.7%) | 16,894 | (73.0%) | 0.512 |
Intubation | 1522 | (66.6%) | 14,942 | (64.6%) | 0.058 |
Tracheostomy | 356 | (15.6%) | 3826 | (16.5%) | 0.249 |
Invasive ventilation | 1991 | (87.1%) | 18,991 | (82.1%) | <0.001 |
Non-invasive ventilation | 62 | (2.7%) | 1132 | (4.9%) | <0.001 |
Renal replacement therapy | 249 | (10.9%) | 2472 | (10.7%) | 0.784 |
Operation while in the ICU | 191 | (8.4%) | 2092 | (9.0%) | 0.292 |
Therapeutic hypothermia | 31 | (1.4%) | 200 | (0.9%) | 0.025 |
Intra-aortic balloon pump | 13 | (0.6%) | 638 | (2.8%) | <0.001 |
Extracorporeal membrane oxygenation | 4 | (0.2%) | 113 | (0.5%) | 0.051 |
Non-Survivors | Survivors | p | ||||
---|---|---|---|---|---|---|
(n = 1092) | (n = 1193) | |||||
Demographic data | Female sex | 241 | (22.1%) | 202 | (16.9%) | 0.002 |
Age >65 years | 164 | (15.0%) | 155 | (13.0%) | 0.182 | |
Admission | First | 1056 | (96.7%) | 1133 | (95.0%) | 0.050 |
Second | 34 | (3.1%) | 58 | (4.9%) | 0.044 | |
Another | 2 | (0.2%) | 2 | (0.2%) | 0.680 | |
Admission source | Operating theatre | 89 | (8.2%) | 137 | (11.5%) | 0.009 |
Emergency department | 436 | (39.9%) | 483 | (40.5%) | 0.818 | |
Surgical department | 192 | (17.6%) | 197 | (16.5%) | 0.533 | |
Medical department | 363 | (33.2%) | 364 | (30.5%) | 0.175 | |
Another ICU | 12 | (1.1%) | 12 | (1.0%) | 0.990 | |
Comorbidities | Coronary artery disease | 171 | (15.7%) | 184 | (15.4%) | 0.922 |
Heart failure | 189 | (17.3%) | 155 | (13.0%) | 0.005 | |
Arterial hypertension | 292 | (26.7%) | 334 | (28.0%) | 0.531 | |
Disseminated atherosclerosis | 234 | (21.4%) | 171 | (14.3%) | <0.001 | |
Chronic respiratory failure | 71 | (6.5%) | 76 | (6.4%) | 0.966 | |
Home oxygen therapy | 2 | (0.2%) | 1 | (0.1%) | 0.939 | |
Extreme obesity | 19 | (1.7%) | 20 | (1.7%) | 0.964 | |
Cachexia | 152 | (13.9%) | 101 | (8.5%) | <0.001 | |
Diabetes | 137 | (12.5%) | 133 | (11.1%) | 0.333 | |
Chronic renal failure | 79 | (7.2%) | 41 | (3.4%) | <0.001 | |
Dialysis dependency | 7 | (0.6%) | 4 | (0.3%) | 0.452 | |
Previous cerebral stroke | 39 | (3.6%) | 39 | (3.3%) | 0.778 | |
Chronic neurological disorders | 107 | (9.8%) | 112 | (9.4%) | 0.793 | |
Systemic autoimmune diseases | 2 | (0.2%) | 2 | (0.2%) | 0.680 | |
Post-transplant | 1 | (0.1%) | 0 | (0.0%) | 0.965 | |
Cancer | 14 | (1.3%) | 13 | (1.1%) | 0.817 | |
Pregnancy | 0 | (0.0%) | 0 | (0.0%) | - | |
Other | 205 | (18.8%) | 188 | (15.8%) | 0.064 |
Variables | Non-Survivors | Survivors | p | ||
---|---|---|---|---|---|
(n = 1092) | (n = 1193) | ||||
Acute respiratory failure | 858 | (78.6%) | 864 | (72.4%) | 0.001 |
Exacerbation of respiratory failure | 36 | (3.3%) | 46 | (3.9%) | 0.545 |
Exacerbation of circulatory failure | 537 | (49.2%) | 320 | (26.8%) | <0.001 |
Multiorgan failure | 281 | (25.7%) | 92 | (7.7%) | <0.001 |
Shock | 460 | (42.1%) | 216 | (18.1%) | <0.001 |
Cardiac arrest | 480 | (44.0%) | 237 | (19.9%) | <0.001 |
Disorders of consciousness | 582 | (53.3%) | 603 | (50.5%) | 0.203 |
Postoperative | 118 | (10.8%) | 167 | (14.0%) | 0.025 |
Multiple trauma | 39 | (3.6%) | 78 | (6.5%) | 0.002 |
Craniocerebral trauma | 115 | (10.5%) | 172 | (14.4%) | 0.006 |
Acute pancreatitis | 53 | (4.9%) | 41 | (3.4%) | 0.090 |
Obstetric complications | 0 | (0.0%) | 0 | (0.0%) | - |
Acute neurological disorders | 85 | (7.8%) | 112 | (9.4%) | 0.197 |
Intoxication | 49 | (4.5%) | 99 | (8.3%) | <0.001 |
Severe metabolic disorders | 201 | (18.4%) | 98 | (8.2%) | <0.001 |
Bacterial infection | 207 | (19.0%) | 207 | (17.4%) | 0.347 |
Sepsis | 94 | (8.6%) | 80 | (6.7%) | 0.092 |
Viral infection | 3 | (0.3%) | 3 | (0.3%) | 0.764 |
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Łowicka-Smolarek, M.; Kokoszka-Bargieł, I.; Knapik, M.; Śmietanka, K.; Dyrda, P.; Możdżeń, M.; Kurczab, M.; Borkowski, J.; Knapik, P. Analysis of Patients with Alcohol Dependence Treated in Silesian Intensive Care Units. Int. J. Environ. Res. Public Health 2022, 19, 5914. https://doi.org/10.3390/ijerph19105914
Łowicka-Smolarek M, Kokoszka-Bargieł I, Knapik M, Śmietanka K, Dyrda P, Możdżeń M, Kurczab M, Borkowski J, Knapik P. Analysis of Patients with Alcohol Dependence Treated in Silesian Intensive Care Units. International Journal of Environmental Research and Public Health. 2022; 19(10):5914. https://doi.org/10.3390/ijerph19105914
Chicago/Turabian StyleŁowicka-Smolarek, Małgorzata, Izabela Kokoszka-Bargieł, Małgorzata Knapik, Konstanty Śmietanka, Piotr Dyrda, Mateusz Możdżeń, Magdalena Kurczab, Jarosław Borkowski, and Piotr Knapik. 2022. "Analysis of Patients with Alcohol Dependence Treated in Silesian Intensive Care Units" International Journal of Environmental Research and Public Health 19, no. 10: 5914. https://doi.org/10.3390/ijerph19105914