A Complex Intervention Integrating Prism Adaptation and Neck Vibration for Unilateral Neglect in Patients of Chronic Stroke: A Randomised Controlled Trial
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Participants
2.2.1. Inclusion Criteria
- Confirmed diagnosis of stroke based on magnetic resonance imaging (MRI) findings;
- Presence of stroke and absence of other diseases;
- A Korean version of Mini-Mental Status Examination (K-MMSE) score ≥ 20, indicating lack of cognitive, auditory, or visual impairment, and the ability to follow instructions [22];
- Onset of stroke at least 6 months earlier;
- Suspected unilateral neglect, based on the Motor-Free Visual Perception Test (MVPT).
2.2.2. Exclusion Criteria
- Participation in another rehabilitation program for unilateral neglect;
- Presence of a medical condition or other reasons that prevent participation in the intervention;
- Apraxia [23].
2.3. Instruments
2.3.1. Korean Mini-Mental State Examination
2.3.2. Motor-Free Visual Perception Test
2.3.3. Albert’s Test
2.3.4. Catherine Bergego Scale
2.3.5. Modified Barthel Index
2.4. Experimental Procedures
2.5. Data Analysis
3. Results
3.1. General Characteristics of the Participants
3.2. Differences from before to after the Intervention
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Selzer, M.E.; Clarke, S.; Cohen, L.G.; Duncan, P.W.; Gage, F.H. Textbook of Neural Repair and Rehabilitation, 1st ed.; Cambridge University Press: New York, NY, USA, 2006; pp. 444–445. [Google Scholar]
- Bowen, A.; Hazelton, C.; Pollock, A.; Lincoln, N.B. Cognitive rehabilitation for spatial neglect following stroke. Cochrane Database Syst. Rev. 2013, 7, CD003586. [Google Scholar] [CrossRef]
- Chechlacz, M.; Rotshtein, P.; Humphreys, G.W. Neuroanatomical dissections of unilateral visual neglect symptoms: ALE meta-analysis of lesion-symptom mapping. Front. Hum. Neurosci. 2012, 6, 230. [Google Scholar] [CrossRef] [Green Version]
- Karnath, H.O.; Ferber, S.; Himmelbach, M. Spatial awareness is a function of the temporal not the posterior parietal lobe. Nature 2001, 411, 950–953. [Google Scholar] [CrossRef]
- Lunven, M.; Schotten, M.T.; Bourlon, C.; Duret, C.; Migliaccio, R.; Rode, G.; Bartolomeo, P. White matter lesional predictors of chronic visual neglect: A longitudinal study. Brain 2015, 138, 746–760. [Google Scholar] [CrossRef]
- Luauté, J.; Halligan, P.; Rode, G.; Rossetti, Y.; Boisson, D. Visuo-spatial neglect: A systematic review of current interventions and their effectiveness. Neurosci. Biobehav. Rev. 2006, 30, 961–982. [Google Scholar] [CrossRef]
- Starkstein, S.E.; Jorge, R.E.; Robinson, R.G. The frequency, clinical correlates, and mechanism of anosognosia after stroke. Can. J. Psychiatry 2010, 55, 355–361. [Google Scholar] [CrossRef] [Green Version]
- Sobrinho, K.R.F.; Santini, A.C.M.; Marques, C.L.S.; Gabriel, M.G.; Neto, E.D.M.; de Souza, L.A.P.S.; Bazan, R.; Luvizutto, G.J. Impact of unilateral spatial neglect on chronic patient’s post-stroke quality of life. Somatosens. Mot. Res. 2018, 35, 199–203. [Google Scholar] [CrossRef]
- Park, H.K.; Kang, Y.J.; Kim, H.J.; Lee, K.S.; Park, K.T. Influence of associated medical diseases and complications on functional improvement after rehabilitation in patients with stroke. Brain Neurorehabilit. 2008, 1, 190–196. [Google Scholar] [CrossRef]
- Pisella, L.; Rode, G.; Farnè, A.; Boisson, D.; Rossetti, Y. Dissociated long lasting improvements of straight-ahead pointing and line bisection tasks in two hemineglect patients. Neuropsychologia 2002, 40, 327–334. [Google Scholar] [CrossRef]
- Humphreys, G.W.; Watelet, A.; Riddoch, M.J. Long-term effects of prism adaptation in chronic visual neglect: A single case study. Cogn. Neuropsychol. 2006, 23, 463–478. [Google Scholar] [CrossRef]
- Lunven, M.; Rode, G.; Bourlon, C.; Duret, C.; Migliaccio, R.; Chevrillon, E.; Schotten, M.T.; Bartolomeo, P. Anatomical predictors of successful prism adaptation in chronic visual neglect. Cortex 2019, 120, 629–641. [Google Scholar] [CrossRef] [PubMed]
- Karnath, H.O. Transcutaneous electrical stimulation and vibration of neck muscles in neglect. Exp. Brain Res. 1995, 105, 321–324. [Google Scholar] [CrossRef] [PubMed]
- Karnath, H.O.; Dieterich, M. Spatial neglect-a vestibular disorder? Brain 2006, 129, 293–305. [Google Scholar] [CrossRef] [Green Version]
- Johannsen, L.; Ackermann, H.; Karnath, H.O. Lasting amelioration of spatial neglect by treatment with neck muscle vibration even without concurrent training. J. Rehabil. Med. 2003, 35, 249–253. [Google Scholar] [CrossRef] [Green Version]
- Saevarsson, S.; Kristjánsson, Á.; Halsband, U. Strength in numbers: Combining neck vibration and prism adaptation produces additive therapeutic effects in unilateral neglect. Neuropsychol. Rehab. 2010, 20, 704–724. [Google Scholar] [CrossRef] [Green Version]
- Saevarsson, S.; Halsband, U.; Kristjánsson, Á. Designing rehabilitation programs for neglect: Could 2 be more than 1 + 1? Appl. Neuropsychol. 2011, 18, 95–106. [Google Scholar] [CrossRef]
- Karnath, H.O.; Christ, K.; Hartje, W. Decrease of contralateral neglect by neck muscle vibration and spatial orientation of trunk midline. Brain 1993, 116, 383–396. [Google Scholar] [CrossRef] [Green Version]
- Schröder, A.; Wist, E.R.; Hömberg, V. TENS and optokinetic stimulation in neglect therapy after cerebrovascular accident: A randomized controlled study. Eur. J. Neurol. 2008, 15, 922–927. [Google Scholar] [CrossRef]
- Choi, H.S.; Kim, D.J.; Yang, Y.A. The effect of a complex intervention program for unilateral neglect in patients with acute-phase stroke: A randomized controlled trial. Osong Public Health Res. Perspect. 2019, 10, 265–273. [Google Scholar] [CrossRef] [Green Version]
- Kim, S.B.; Lee, K.W.; Lee, J.H.; Lee, S.J.; Park, J.G.P.; Lee, J.B. Effect of combined therapy of robot and low frequency repetitive transcranial magnetic stimulation on hemispatial neglect in stroke patients. Ann. Rehabil. Med. 2018, 42, 788–797. [Google Scholar] [CrossRef]
- Kang, Y.W.; Na, D.L.; Hahn, S.H. A Validity study on the Korean Mini-Mental State Examination (K-MMSE) in dementia patients. J. Korean Neurol. Assoc. 1997, 15, 300–308. [Google Scholar]
- Varalta, V.; Picelli, A.; Fonte, C.; Montemezzi, G.; La Marchina, E.; Smania, N. Effects of contralesional robot-assisted hand training in patients with unilateral spatial neglect following stroke: A case series study. J. Neuroeng. Rehabil. 2014, 11, 160. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Han, T.R.; Shin, H.I.; Kim, S.J. The Effect of prism treatment in patients with stroke with unilateral ignorance—Preliminary study. Ann. Rehabil. Med. 2001, 25, 412–417. [Google Scholar]
- Bouska, M.J.; Kwatny, E. Manual for Application of Motor-Free Visual Perception Test to the Adult Population; Academic Therapy Publication: Philadelphia, PA, USA, 1983. [Google Scholar]
- Albert, M.L. A simple test of visual neglect. Neurology 1973, 23, 658–664. [Google Scholar] [CrossRef]
- Azouvi, P.; Bartolomeo, P.; Beis, J.M.; Perennou, D.; Pradat-Diehl, P.; Rousseaux, M. A battery of tests for the quantitative assessment of unilateral neglect. Restor. Neurol. Neurosci. 2006, 24, 273–285. [Google Scholar]
- Azouvi, P.; Olivier, S.; De Montety, G.; Samuel, C.; Louis-Dreyfus, A.; Tesio, L. Behavioral assessment of unilateral neglect: Study of the psychometric properties of the Catherine Bergego Scale. Arch. Phys. Med. Rehabil. 2003, 84, 51–57. [Google Scholar] [CrossRef]
- Shah, S.; Vanclay, F.; Cooper, B. Improving the sensitivity of the Barthel Index for stroke rehabilitation. J. Clin. Epidemiol. 1989, 42, 703–709. [Google Scholar] [CrossRef]
- Rode, G.; Pisella, L.; Mercier, S.; Rossetti, Y.; Boisson, D. Prism adaptation improves spatial dysgraphia following right brain damage. Neuropsychologia 2006, 44, 2487–2493. [Google Scholar] [CrossRef]
- Rossetti, Y.; Rode, G.; Pisella, L.; Farné, A.; Li, L.; Boisson, D.; Perenin, M.T. Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect. Nature 1998, 395, 166–169. [Google Scholar] [CrossRef]
- Redding, G.M.; Wallace, B. Prism adaptation and unilateral neglect: Review and analysis. Neuropsychologia 2006, 44, 1–20. [Google Scholar] [CrossRef]
- McIntyre, S.; Seizova-Cajic, T. Neck muscle vibration in full cues affects pointing. J. Vis. 2007, 7, 9. [Google Scholar] [CrossRef] [PubMed]
- Kamada, K.; Shimodozono, M.; Hamada, H.; Kawahira, K. Effects of 5 minutes of neck-muscle vibration immediately before occupational therapy on unilateral spatial neglect. Disabil. Rehabil. 2011, 33, 2322–2328. [Google Scholar] [CrossRef] [PubMed]
- Mizuno, K.; Tsuji, T.; Takebayashi, T.; Fujiwara, T.; Hase, K.; Liu, M. Prism adaptation therapy enhances rehabilitation of stroke patients with unilateral spatial neglect: A randomized, controlled trial. Neurorehabil. Neural Repair 2011, 25, 711–720. [Google Scholar] [CrossRef] [PubMed]
- Jung, E.H.; Park, J.H. A Review of Prism Adaptation Treatment in Stroke patients with spatial neglect. Korean J. Occup. Ther. 2016, 24, 81–96. [Google Scholar] [CrossRef]
- Chen, P.; Hreha, K.; Gonzlaez-Snyder, C. Impacts of prism adaptation treatment on spatial neglect and rehabilitation outcome: Dosage matters. Neurorehabil. Neural Repair 2022, 36, 500–513. [Google Scholar] [CrossRef] [PubMed]
- Goodwin, G.M.; McCloskey, D.I.; Matthews, P.B. The contribution of muscle afferents to kinaesthesia shown by vibration induced illusions of movement and by the effects of paralysing joint afferents. Brain 1972, 95, 705–748. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Bakker, D.A.; Richmond, F.J.R. Muscle spindle complexes in muscle around upper cervical vertebrae in the cat. J. Neurophysiol. 1982, 48, 62–74. [Google Scholar] [CrossRef]
- Machner, B.; Könemund, I.; Sprenger, A.; von der Gablentz, J.; Helmchen, C. Randomized controlled trial on Hemifield eye patching and optokinetic stimulation in acute spatial neglect. Stroke 2014, 45, 2465–2468. [Google Scholar] [CrossRef] [Green Version]
- Brandt, T.; Welfringer, A. Treatment of neglect: New therapy approaches. Der Nervenarzt 2016, 87, 1068–1073. [Google Scholar] [CrossRef]
- Kortte, K.B.; Hillis, A.E. Recent trends in rehabilitation interventions for visual neglect and anosognosia for hemiplegia following right hemisphere stroke. Future Neurol. 2011, 6, 33–43. [Google Scholar] [CrossRef] [Green Version]
- Schinlder, I.; Kerkgoff, G.; Karnath, H.-O.; Keller, I.; Goldenberg, G. Neck muscle vibration induces lasting recovery in spatial neglect. J. Neurol. Neurosurg. Psychiatry 2002, 73, 412–419. [Google Scholar]
- Luauté, J.; Schwartz, S.; Rossetti, Y.; Spiridon, M.; Rode, G.; Boisson, D.; Vuilleumier, P. Dynamic changes in brain activity during prism adaptation. J. Neurosci. 2009, 29, 169–178. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Bottini, G.; Karnath, H.-O.; Vallar, G.; Sterzi, R.; Frith, C.D.; Frackowiak, R.S.J.; Frackowiak, E.; Paulesu, E. Cerebral representations for egocentric space: Functional-anatomical evidence from caloric vestibular stimulation and neck vibration. Brain 2001, 124, 1182–1192. [Google Scholar] [CrossRef] [PubMed]
Characteristics | Group A | Group B | Group C | p | |
---|---|---|---|---|---|
Sex | Male | 7 | 4 | 6 | 0.886 |
Female | 5 | 8 | 6 | ||
Onset (months) | 8.92 ± 2.64 | 9.70 ± 3.16 | 9.37 ± 2.85 | 0.78 | |
Age (years) | 62.90 ± 8.64 | 67.70 ± 9.76 | 66.00 ± 12.09 | 0.58 | |
K-MMSE (score) | 22.40 ± 1.47 | 23.60 ± 1.26 | 22.03 ± 1.71 | 0.26 | |
MVPT (score) | 6.91 ± 1.66 | 6.63 ± 2 = 1.38 | 7.21 ± 2.30 | 0.82 | |
Cause of injury | Cerebral haemorrhage | 8 | 5 | 9 | 0.87 |
Cerebral infarction | 4 | 7 | 3 |
Variables | Group A (a) (n = 12) | Group B (b) (n = 12) | Group C (c) (n = 12) | F | p |
---|---|---|---|---|---|
MBI | 0.333 | ||||
Pre-test | 47.69 ± 2.75 | 49.30 ± 2.49 | 46.30 ± 4.29 | 1.145 | |
Post-test | 58.10 ± 2.76 | 58.30 ± 3.65 | 55.60 ± 3.50 | ||
Within-group changes t | 10.50 ± 2.71 (−12.215) ** | 9.10 ± 2.53 (−11.211) ** | 9.30 ± 1.63 (−17.972) ** | ||
Albert’s test | 9.398 (a > b, c) | 0.001 ** | |||
Pre-test | 7.80 ± 1.75 | 7.30 ± 0.95 | 7.80 ± 1.75 | ||
Post-test | 5.00 ± 2.21 | 5.70 ± 1.48 | 5.00 ± 2.21 | ||
Within-group changes t | 2.80 ± 0.91 (10.811) ** | 1.60 ± 0.84 (6.002) ** | 1.30 ± 0.67 (6.091) ** | ||
CBS | 0.041 * | ||||
Pre-test | 20.90 ± 2.99 | 19.00 ± 2.98 | 20.10 ± 2.77 | 3.598 (a > b, c) | |
Post-test | 14.70 ± 1.70 | 14.80 ± 3.10 | 15.40 ± 2.13 | ||
Within-group changes t | 6.20 ± 1.85 (9.635) ** | 4.20 ± 1.81 (7.324) ** | 4.70 ± 1.89 (9.485) ** |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Choi, H.-S.; Lee, B.-M. A Complex Intervention Integrating Prism Adaptation and Neck Vibration for Unilateral Neglect in Patients of Chronic Stroke: A Randomised Controlled Trial. Int. J. Environ. Res. Public Health 2022, 19, 13479. https://doi.org/10.3390/ijerph192013479
Choi H-S, Lee B-M. A Complex Intervention Integrating Prism Adaptation and Neck Vibration for Unilateral Neglect in Patients of Chronic Stroke: A Randomised Controlled Trial. International Journal of Environmental Research and Public Health. 2022; 19(20):13479. https://doi.org/10.3390/ijerph192013479
Chicago/Turabian StyleChoi, Hyun-Se, and Bo-Min Lee. 2022. "A Complex Intervention Integrating Prism Adaptation and Neck Vibration for Unilateral Neglect in Patients of Chronic Stroke: A Randomised Controlled Trial" International Journal of Environmental Research and Public Health 19, no. 20: 13479. https://doi.org/10.3390/ijerph192013479