Cost-Effectiveness of the Comprehensive Interdisciplinary Program-Care in Informal Caregivers of People with Alzheimer’s Disease
, María José González-Becerra 2,*, Sabina Barrios-Fernández 1, Salvador Postigo-Mota 3, María del Rocío Jerez-Barroso 1, Juan Agustín Franco Martínez 4, Belén Suárez-Lantarón 5, Diego Muñoz Marín 6, Nieves Martín-Bermúdez 7, Raquel Ortés-Gómez 8, Martín Gómez-Ullate-García de León 9, Marta Martínez-Acevedo 10, Lara Rocha-Gómez 11, Sara Espejo-Antúnez 12, Mercedes Fraile-Bravo 4, María Gloria Solís Galán 12, Ignacio Chato-Gonzalo 13, Francisco Javier Domínguez Muñoz 14, Miguel Ángel Hernández-Mocholí 14, Miguel Madruga-Vicente 14, María Mendoza-Muñoz 15, Jorge Carlos-Vivas 4, Jorge Pérez-Gómez 4, Raquel Pastor-Cisneros 1, Damián Pereira-Payo 16, Javier De Los Ríos-Calonge 16, Javier Urbano-Mairena 16, Joan Guerra-Bustamante 4 and José Carmelo Adsuar 16add
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Round 1
Reviewer 1 Report
1. Introduction is too long and cost-effectiveness studies related to this paper are not reviewed well.
2. The context does not match the subtitle ‘Cost-Effectiveness Analysis’.
3. The spelling of ‘HRQoL’ and ‘HRQOL’ needs to be unified.
4. Based on CONSORT and SPIRIT checklist, data management, quality control, and proposed study timeline should be provided.
Author Response
Dear Reviewer,
We appreciate your comments and recommendations to improve our manuscript.
The detailed comments are as follows:
- Introduction is too long and cost-effectiveness studies related to this paper are not reviewed well.
We thank you for your appreciation and agree. The information provided in the introduction has been shortened. The bibliography used to develop the background has also been updated. In doing so, we believe that the introduction and contextualisation have improved the quality of the article.
- The context does not match the subtitle ‘Cost-Effectiveness Analysis’.
Thank you for your comment. We have redrafted the introduction and addressed in the contextualisation the importance of cost-benefit analysis using up-to-date literature.
- The spelling of ‘HRQoL’ and ‘HRQOL’ needs to be unified.
Thank you for this contribution, we have modified the acronyms in response to your comment.
- Based on CONSORT and SPIRIT checklist, data management, quality control, and proposed study timeline should be provided.
We thank you for your comment, and in this regard we have proceeded to include data management, quality control and the timeline of the study in the manuscript.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
Dear Authors,
The study protocol manuscript titled "Cost-effectiveness of the comprehensive interdisciplinary Program-Care in informal caregivers of people with Alzheimer's disease" is well written and seems to be clearly organized. However, in my opinion, a better and updated references concerning the background of the study should be mentioned. Indeed only few papers of the last three years were cited (doi: 10.31887/DCNS.2009.11.2/hbrodaty; doi: 10.31887/DCNS.2000.2.2/mdavidson; doi: 10.14283/jpad.2022.53; doi: /10.1007/s40273-019-00788-3; doi: 10.1186/s13195-022-00969-x). On the other, since no study protocol like the one the Authors proposed are present in the main literature, this should be better underlined.
Moreover, I have some questions and suggestions on the materials and methods section in order to improved the quality of your paper.
1- concerning the enrollment criteria, the Authors should underline that the study considers also age and gender as mentioned in 2.7.3 subheading, adding few sentences also in the 2.1 or 2.3 subheading.
2- Did the Authors have preliminary results?
3- Please, add the full text for HRQOL (Health-Related Quality Of Life).
4- Please, always use the same abbreviations: "HRQOL" or "HRQoL".
5- Table 1: I suggest the Authors to divide each line, such as "Physics", "Phycoemotional" and "Cognitive-behavioral and health education", by a stripe or additional space in order to better distinguish the "Module" column.
Author Response
Dear Reviewer,
We appreciate your comments and recommendations to improve our manuscript.
The detailed comments are as follows:
REVIEWER 2
Dear Authors,
The study protocol manuscript titled "Cost-effectiveness of the comprehensive interdisciplinary Program-Care in informal caregivers of people with Alzheimer's disease" is well written and seems to be clearly organized. However, in my opinion, a better and updated references concerning the background of the study should be mentioned. Indeed only few papers of the last three years were cited (doi: 10.31887/DCNS.2009.11.2/hbrodaty; doi: 10.31887/DCNS.2000.2.2/mdavidson; doi: 10.14283/jpad.2022.53; doi: /10.1007/s40273-019-00788-3; doi: 10.1186/s13195-022-00969-x). On the other, since no study protocol like the one the Authors proposed are present in the main literature, this should be better underlined.
Thank you for your appreciation. We have updated the bibliography used to develop the background to the study and we believe that this has enriched the introduction.
In addition, the discussion section has underlined the importance of being a pioneering study in the field of carers of people with Alzheimer's disease.
Moreover, I have some questions and suggestions on the materials and methods section in order to improved the quality of your paper.
1- concerning the enrollment criteria, the Authors should underline that the study considers also age and gender as mentioned in 2.7.3 subheading, adding few sentences also in the 2.1 or 2.3 subheading.
We welcome your comments. The measures of age and sex will form part of the socio-demographic data for the characterisation of the sample, however, they do not represent an admission criterion to form part of the sample. For this reason, both variables are considered secondary measures of the study.
2- Did the Authors have preliminary results?
The project is currently in the sample recruitment phase, so we do not have preliminary data from the comprehensive interdisciplinary care programme for informal carers of people with Alzheimer's disease.
3- Please, add the full text for HRQOL (Health-Related Quality Of Life).
Thank you for your appreciation, we have used "health-related quality of life" for the first time and indicated the acronym.
4- Please, always use the same abbreviations: "HRQOL" or "HRQoL".
Thank you for this contribution, we have modified the acronyms in response to your comment.
5- Table 1: I suggest the Authors to divide each line, such as "Physics", "Phycoemotional" and "Cognitive-behavioral and health education", by a stripe or additional space in order to better distinguish the "Module" column.
We agree with this, table 1 has been divided into modules.
Author Response File: Author Response.pdf
Round 2
Reviewer 1 Report
Authors revised the manuscript well. I have no further comments.
