Circadian Clock Desynchronization and Insulin Resistance
Abstract
:1. Introduction
2. Impact of Central and Peripheral Clocks Misalignment
3. Impact of Circadian Secretory Profiles
4. Role of the Microbiome
5. Candidate Mediator Molecules
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Organ/System | CR Regulated Function | Direct Effect When CR Is Altered | Output |
---|---|---|---|
GI tract | Motility | Altered transit time | Impaired insulin signaling due to gluco/lipo toxicity |
Nutrient digestion and absorption | Increased/decreased nutrient flux | Impaired insulin signaling due to gluco/lipo toxicity | |
Incretin release | Altered insulin secretion | Hypo/Hyperinsulinemia, InsR downregulation | |
Liver | Nutrient utilization | Altered FA and glucose flux | Impaired insulin signaling due to gluco/lipo toxicity |
Skeletal muscle | Response to physical activity | Impaired energy consumption | Reduced insulin sensitizing potential of physical activity |
Adipose tissue | Differentiation | Altered fat depots | Impaired insulin signaling due to inflammation |
Secretion of inflammatory factors | Inflammation | Impaired insulin signaling due to inflammation | |
Resistin release | Altered food intake and energy expenditure | Impaired insulin signaling due to gluco/lipo toxicity | |
Visfatin release | Increased inflammation | Impaired insulin signaling due to inflammation | |
Adiponectin release | Altered energy metabolism | Impaired insulin signaling due to gluco/lipo toxicity | |
Resistin release | Increased proinflammatory cytokines secretion | Impaired insulin signaling due to inflammation | |
Liver/adipose tissue | RBP4 release | Time-dependent activation of JAK/STAT pathway | Impaired insulin signaling due to JAK/STAT induced genes |
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Catalano, F.; De Vito, F.; Cassano, V.; Fiorentino, T.V.; Sciacqua, A.; Hribal, M.L. Circadian Clock Desynchronization and Insulin Resistance. Int. J. Environ. Res. Public Health 2023, 20, 29. https://doi.org/10.3390/ijerph20010029
Catalano F, De Vito F, Cassano V, Fiorentino TV, Sciacqua A, Hribal ML. Circadian Clock Desynchronization and Insulin Resistance. International Journal of Environmental Research and Public Health. 2023; 20(1):29. https://doi.org/10.3390/ijerph20010029
Chicago/Turabian StyleCatalano, Federica, Francesca De Vito, Velia Cassano, Teresa Vanessa Fiorentino, Angela Sciacqua, and Marta Letizia Hribal. 2023. "Circadian Clock Desynchronization and Insulin Resistance" International Journal of Environmental Research and Public Health 20, no. 1: 29. https://doi.org/10.3390/ijerph20010029