Particulate Air Pollution Exposure and Stroke among Adults in Israel
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Population and Outcome
2.2. Exposure
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Saini, V.; Guada, L.; Yavagal, D.R. Global Epidemiology of Stroke and Access to Acute Ischemic Stroke Interventions. Neurology 2021, 97, S6. [Google Scholar] [CrossRef] [PubMed]
- Scheers, H.; Jacobs, L.; Casas, L.; Nemery, B.; Nawrot, T.S. Long-Term Exposure to Particulate Matter Air Pollution Is a Risk Factor for Stroke. Stroke 2015, 46, 3058–3066. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Verhoeven, J.I.; Allach, Y.; Vaartjes, I.C.H.; Klijn, C.J.M.; de Leeuw, F.-E. Ambient air pollution and the risk of ischaemic and haemorrhagic stroke. Lancet Planet. Health 2021, 5, e542–e552. [Google Scholar] [CrossRef] [PubMed]
- Glencross, D.A.; Ho, T.-R.; Camiña, N.; Hawrylowicz, C.M.; Pfeffer, P.E. Air pollution and its effects on the immune system. Free Radic. Biol. Med. 2020, 151, 56–68. [Google Scholar] [CrossRef]
- Genc, S.; Zadeoglulari, Z.; Fuss, S.H.; Genc, K. The adverse effects of air pollution on the nervous system. J. Toxicol. 2012, 2012, 782462. [Google Scholar] [CrossRef] [Green Version]
- Birben, E.; Sahiner, U.M.; Sackesen, C.; Erzurum, S.; Kalayci, O. Oxidative stress and antioxidant defense. World Allergy Organ J. 2012, 5, 9–19. [Google Scholar] [CrossRef] [Green Version]
- Brook, R.D.; Rajagopalan, S.; Pope, C.A., III; Brook, J.R.; Bhatnagar, A.; Diez-Roux, A.V.; Holguin, F.; Hong, Y.; Luepker, R.V.; Mittleman, M.A.; et al. Particulate Matter Air Pollution and Cardiovascular Disease An Update to the Scientific Statement from the American Heart Association. Circulation 2010, 121, 2331–2378. [Google Scholar] [CrossRef] [Green Version]
- Gu, J.; Shi, Y.; Chen, N.; Wang, H.; Chen, T. Ambient fine particulate matter and hospital admissions for ischemic and hemorrhagic strokes and transient ischemic attack in 248 Chinese cities. Sci. Total Environ. 2020, 715, 136896. [Google Scholar] [CrossRef]
- Tian, Y.; Liu, H.; Wu, Y.; Si, Y.; Song, J.; Cao, Y.; Li, M.; Wu, Y.; Wang, X.; Chen, L.; et al. Association between ambient fine particulate pollution and hospital admissions for cause specific cardiovascular disease: Time series study in 184 major Chinese cities. BMJ 2019, 367, l6572. [Google Scholar] [CrossRef] [Green Version]
- Yuan, S.; Wang, J.; Jiang, Q.; He, Z.; Huang, Y.; Li, Z.; Cai, L.; Cao, S. Long-term exposure to PM(2.5) and stroke: A systematic review and meta-analysis of cohort studies. Environ. Res. 2019, 177, 108587. [Google Scholar] [CrossRef] [PubMed]
- Konduracka, E.; Rostoff, P. Links between chronic exposure to outdoor air pollution and cardiovascular diseases: A review. Environ. Chem. Lett. 2022, 20, 2971–2988. [Google Scholar] [CrossRef]
- Yitshak-Sade, M.; Novack, V.; Katra, I.; Rafael, G.; Tal, A.; Novack, L. Non anthropogenic dust exposure and asthma medications purchase in children. Eur. Respir. J. 2014, 45, 652–660. [Google Scholar] [CrossRef]
- Yitshak-Sade, M.; Yudovitch, D.; Novack, V.; Tal, A.; Kloog, I.; Goldbart, A. Air Pollution and Hospitalization for Bronchiolitis among Young Children. Ann. Am. Thorac. Soc. 2017, 14, 1796–1802. [Google Scholar] [CrossRef]
- Zanobetti, A.; Schwartz, J. Are diabetics more susceptible to the health effects of airborne particles? Am. J. Respir. Crit. Care Med. 2001, 164, 831–833. [Google Scholar] [CrossRef]
- Zanobetti, A.; Schwartz, J. Cardiovascular damage by airborne particles: Are diabetics more susceptible? Epidemiology 2002, 13, 588–592. [Google Scholar] [CrossRef]
- Bateson, T.F.; Schwartz, J. Who is sensitive to the effects of particulate air pollution on mortality? A case-crossover analysis of effect modifiers. Epidemiology 2004, 15, 143–149. [Google Scholar] [CrossRef] [Green Version]
- O’Neill, M.S.; Breton, C.V.; Devlin, R.B.; Utell, M.J. Air pollution and health: Emerging information on susceptible populations. Air Qual. Atmos. Health 2012, 5, 189–201. [Google Scholar] [CrossRef] [Green Version]
- Provençal, S.; Buchard, V.; da Silva, A.M.; Leduc, R.; Barrette, N.; Elhacham, E.; Wang, S.H. Evaluation of PM(2.5) surface concentration simulated by Version 1 of the NASA’s MERRA Aerosol Reanalysis over Israel and Taiwan. Aerosol. Air Qual. Res. 2017, 17, 253–261. [Google Scholar] [CrossRef] [Green Version]
- The World Bank. PM2.5 Air Pollution, Mean Annual Exposure. Available online: https://data.worldbank.org/indicator/EN.ATM.PM25.MC.M3?locations=IL-US-CA-IT&most_recent_value_desc=true (accessed on 1 October 2022).
- Abdeen, Z.; Qasrawi, R.; Heo, J.; Wu, B.; Shpund, J.; Vanger, A.; Sharf, G.; Moise, T.; Brenner, S.; Nassar, K.; et al. Spatial and temporal variation in fine particulate matter mass and chemical composition: The Middle East Consortium for Aerosol Research Study. Sci. World J. 2014, 2014, 878704. [Google Scholar] [CrossRef] [Green Version]
- Kloog, I.; Sorek-Hamer, M.; Lyapustin, A.; Coull, B.; Wang, Y.; Just, A.C.; Schwartz, J.; Broday, D.M. Estimating daily PM(2.5) and PM(10) across the complex geo-climate region of Israel using MAIAC satellite-based AOD data. Atmos. Environ. (1994) 2015, 122, 409–416. [Google Scholar] [CrossRef]
- Rosenfeld, A.; Dorman, M.; Schwartz, J.; Novack, V.; Just, A.C.; Kloog, I. Estimating daily minimum, maximum, and mean near surface air temperature using hybrid satellite models across Israel. Environ. Res. 2017, 159, 297–312. [Google Scholar] [CrossRef]
- Janes, H.; Sheppard, L.; Lumley, T. Case-crossover analyses of air pollution exposure data: Referent selection strategies and their implications for bias. Epidemiology 2005, 16, 717–726. [Google Scholar] [CrossRef]
- Huang, K.; Liang, F.; Yang, X.; Liu, F.; Li, J.; Xiao, Q.; Chen, J.; Liu, X.; Cao, J.; Shen, C.; et al. Long term exposure to ambient fine particulate matter and incidence of stroke: Prospective cohort study from the China-PAR project. BMJ 2019, 367, l6720. [Google Scholar] [CrossRef] [Green Version]
- Di, Q.; Dai, L.; Wang, Y.; Zanobetti, A.; Choirat, C.; Schwartz, J.D.; Dominici, F. Association of Short-term Exposure to Air Pollution With Mortality in Older Adults. JAMA 2017, 318, 2446–2456. [Google Scholar] [CrossRef]
- Dominici, F.; Schwartz, J.; Di, Q.; Braun, D.; Choirat, C.; Zanobetti, A. Assessing Adverse Health Effects of Long-Term Exposure to Low Levels of Ambient Air Pollution: Phase 1. Res. Rep. Health Eff. Inst. 2019, 2019, 200. [Google Scholar]
- Yitshak-Sade, M.; Lane, K.J.; Fabian, M.P.; Kloog, I.; Hart, J.E.; Davis, B.; Fong, K.C.; Schwartz, J.D.; Laden, F.; Zanobetti, A. Race or racial segregation? Modification of the PM2.5 and cardiovascular mortality association. PLoS ONE 2020, 15, e0236479. [Google Scholar] [CrossRef]
- Sade, M.Y.; Shi, L.; Colicino, E.; Amini, H.; Schwartz, J.D.; Di, Q.; Wright, R.O. Long-term air pollution exposure and diabetes risk in American older adults: A national cohort study. medRxiv 2022. [Google Scholar] [CrossRef]
- Danesh Yazdi, M.; Wang, Y.; Di, Q.; Zanobetti, A.; Schwartz, J. Long-term exposure to PM(2.5) and ozone and hospital admissions of Medicare participants in the Southeast USA. Environ. Int. 2019, 130, 104879. [Google Scholar] [CrossRef]
- U.S Environmental Protection Agency. Available online: https://www.epa.gov/criteria-air-pollutants/naaqs-table (accessed on 9 December 2022).
- Wolf, K.; Hoffmann, B.; Andersen, Z.J.; Atkinson, R.W.; Bauwelinck, M.; Bellander, T.; Brandt, J.; Brunekreef, B.; Cesaroni, G.; Chen, J.; et al. Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: A pooled analysis of six European cohorts within the ELAPSE project. Lancet Planet. Health 2021, 5, e620–e632. [Google Scholar] [CrossRef]
- World Health Organization (WHO). WHO Global Air Quality Guidelines: Particulate Matter (PM2.5 and PM10), Ozone, Nitrogen Dioxide, Sulfur Dioxide and Carbon Monoxide: Executive Summary; WHO: Geneva, Switzerland, 2021.
- Stockfelt, L.; Andersson, E.M.; Molnár, P.; Gidhagen, L.; Segersson, D.; Rosengren, A.; Barregard, L.; Sallsten, G. Long-term effects of total and source-specific particulate air pollution on incident cardiovascular disease in Gothenburg, Sweden. Environ. Res. 2017, 158, 61–71. [Google Scholar] [CrossRef]
- Dong, H.; Yu, Y.; Yao, S.; Lu, Y.; Chen, Z.; Li, G.; Yao, Y.; Yao, X.; Wang, S.L.; Zhang, Z. Acute effects of air pollution on ischaemic stroke onset and deaths: A time-series study in Changzhou, China. BMJ Open 2018, 8, e020425. [Google Scholar] [CrossRef] [PubMed]
- Xue, T.; Guan, T.; Liu, Y.; Zheng, Y.; Guo, J.; Fan, S.; Zhang, Q. A national case-crossover study on ambient ozone pollution and first-ever stroke among Chinese adults: Interpreting a weak association via differential susceptibility. Sci. Total Environ. 2019, 654, 135–143. [Google Scholar] [CrossRef] [PubMed]
- Kim, C.S.; Hu, S.C. Regional deposition of inhaled particles in human lungs: Comparison between men and women. J. Appl. Physiol. 1998, 84, 1834–1844. [Google Scholar] [CrossRef] [PubMed]
- Simaan, N.; Filioglo, A.; Honig, A.; Horev, A.; Orion, D.; Bornstein, N.M.; Telman, G.; Tanne, D.; Raphaeli, G.; Amsalem, J.; et al. Are there disparities in acute stroke treatment between the Jewish and Arab populations in Israel? Results from the National Acute Stroke Israeli registry. J. Neurol. Sci. 2021, 423, 117357. [Google Scholar] [CrossRef] [PubMed]
- Chu, M.T.; Fenelon, A.; Rodriguez, J.; Zota, A.R.; Adamkiewicz, G. Development of a multidimensional housing and environmental quality index (HEQI): Application to the American Housing Survey. Environ. Health 2022, 21, 56. [Google Scholar] [CrossRef]
- Ho, A.F.W.; Zheng, H.; De Silva, D.A.; Wah, W.; Earnest, A.; Pang, Y.H.; Xie, Z.; Pek, P.P.; Liu, N.; Ng, Y.Y.; et al. The Relationship Between Ambient Air Pollution and Acute Ischemic Stroke: A Time-Stratified Case-Crossover Study in a City-State With Seasonal Exposure to the Southeast Asian Haze Problem. Ann. Emerg. Med. 2018, 72, 591–601. [Google Scholar] [CrossRef]
- Tian, Y.; Liu, H.; Zhao, Z.; Xiang, X.; Li, M.; Juan, J.; Song, J.; Cao, Y.; Wang, X.; Chen, L.; et al. Association between ambient air pollution and daily hospital admissions for ischemic stroke: A nationwide time-series analysis. PLoS Med. 2018, 15, e1002668. [Google Scholar] [CrossRef] [Green Version]
- Yitshak Sade, M.; Novack, V.; Ifergane, G.; Horev, A.; Kloog, I. Air Pollution and Ischemic Stroke Among Young Adults. Stroke 2015, 46, 3348–3353. [Google Scholar] [CrossRef]
- Krasnov, H.; Kloog, I.; Friger, M.; Katra, I. The Spatio-Temporal Distribution of Particulate Matter during Natural Dust Episodes at an Urban Scale. PLoS ONE 2016, 11, e0160800. [Google Scholar] [CrossRef] [Green Version]
- Tibuakuu, M.; Michos, E.D.; Navas-Acien, A.; Jones, M.R. Air Pollution and Cardiovascular Disease: A Focus on Vulnerable Populations Worldwide. Curr. Epidemiol. Rep. 2018, 5, 370–378. [Google Scholar] [CrossRef]
Sex | |
Female | 34,347 (46.4) |
Male | 39,705 (53.6) |
Age | 71.7 (13.6) |
Ethnicity | |
Jewish | 59,900 (80.9) |
Arab | 11,217 (15.1) |
Other | 2940 (4.0) |
Primary diagnosis | |
Intracranial hemorrhage | 5685 (7.7) |
Ischemic stroke | 47,959 (64.6) |
Transient ischemic attack | 20,413 (27.7) |
Diabetes | 32,543 (43.9) |
Hypertension | 56,896 (76.8) |
Hyperlipidemia | 52,341 (70.7) |
Atrial fibrillation | 15,258 (20.6) |
Congestive heart failure | 10,623 (14.3) |
Ischemic heart disease | 23,335 (31.5) |
Obesity | 7162 (9.6) |
History of myocardial infarction | 2164 (2.9) |
Outcome | % Change (95% CI) | p Value |
---|---|---|
Ischemic stroke | ||
Lag 0 | 1.70% (0.15%; 3.28%) | 0.030 |
Lag 1 | 0.11% (−0.72%; 0.95%) | 0.795 |
Lag 2 | −0.36% (−0.91%; 0.18%) | 0.196 |
ICH | ||
Lag 0 | −4.43% (−8.57%; −0.09%) | 0.045 |
Lag 1 | −0.37% (−2.57%; 1.87%) | 0.740 |
Lag 2 | −0.26% (−1.66%; 1.16%) | 0.717 |
TIA | ||
Lag 0 | 2.74% (0.37%; 5.17%) | 0.023 |
Lag 1 | −0.44% (−1.78%; 0.91%) | 0.521 |
Lag 2 | −0.52% (−1.37%; 0.33%) | 0.231 |
Outcome | Main Analysis | Restricted to Cases with Exact Addresses |
---|---|---|
Ischemic stroke | 1.70% (0.15%; 3.28%) | 1.42% (−0.36%; 3.25%) |
ICH | −4.43% (−8.57%; −0.09%) | −4.52% (−9.33%; 0.52%) |
TIA | 2.74% (0.37%; 5.17%) | 2.60% (−0.12%; 5.40%) |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Gaines, B.; Kloog, I.; Zucker, I.; Ifergane, G.; Novack, V.; Libruder, C.; Hershkovitz, Y.; Sheffield, P.E.; Yitshak-Sade, M. Particulate Air Pollution Exposure and Stroke among Adults in Israel. Int. J. Environ. Res. Public Health 2023, 20, 1482. https://doi.org/10.3390/ijerph20021482
Gaines B, Kloog I, Zucker I, Ifergane G, Novack V, Libruder C, Hershkovitz Y, Sheffield PE, Yitshak-Sade M. Particulate Air Pollution Exposure and Stroke among Adults in Israel. International Journal of Environmental Research and Public Health. 2023; 20(2):1482. https://doi.org/10.3390/ijerph20021482
Chicago/Turabian StyleGaines, Britney, Itai Kloog, Inbar Zucker, Gal Ifergane, Victor Novack, Carmit Libruder, Yael Hershkovitz, Perry E. Sheffield, and Maayan Yitshak-Sade. 2023. "Particulate Air Pollution Exposure and Stroke among Adults in Israel" International Journal of Environmental Research and Public Health 20, no. 2: 1482. https://doi.org/10.3390/ijerph20021482