Association between Sarcopenia, Falls, and Cognitive Impairment in Older People: A Systematic Review with Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Database | Search Strategy | Results |
---|---|---|
BVS | ((mh:(“Acidentes por Quedas”)) OR (“Acidentes por Quedas” OR “Accidental Falls” OR “Accidentes por Caídas”)) AND ((mh:(Idoso)) OR (Idoso OR Aged OR Anciano)) AND ((mh:(Sarcopenia)) OR (Sarcopenia)) AND ((mh:(“Disfunção Cognitiva”)) OR (“Disfunção Cognitiva” OR “Cognitive Dysfunction” OR “Disfunción Cognitiva”)) | 9 |
PUBMED | (((“Accidental Falls”[Mesh] OR “Accidental Falls” OR “Accidental Fall”) AND (“Aged”[Mesh] OR Aged)) AND (“Sarcopenia”[Mesh] OR Sarcopenia)) AND (“Cognitive Dysfunction”[Mesh] OR “Cognitive Dysfunction”) | 7 |
CINAHL | ((MH “Accidental Falls”) OR “Accidental Falls” OR “Accidental Fall”) AND ((MH “Aged”) OR Aged) AND ((MH “Sarcopenia”) OR Sarcopenia) AND ((((MH “Cognition Disorders”) OR “Cognitive Disorders” OR “Cognitive Dysfunction”)) OR ((MH “Cognitive Aging”) OR “Cognitive Aging”))) | 11 |
EMBASE | (falls OR “accidental falls” OR falling) AND (Aged) AND (Sarcopenia) AND (“cognitive defect” OR “cognitive dysfunction” OR “cognitive disorder” OR “cognitive disorders”) | 82 |
SCOPUS | ((fall*) AND (aged) AND (sarcopenia) AND ({cognitive defect} OR {cognitive dysfunction} OR {cognitive disorder} OR {cognitive disorders})) | 72 |
Web of Science | (fall*) AND (Aged) AND (Sarcopenia) AND (“cognitive defect” OR “cognitive dysfunction” OR “cognitive disorder” OR “cognitive disorders”) | 9 |
Google Scholar | (“Accidental Falls”) AND (Aged) AND (Sarcopenia) AND (“cognitive defect” OR “cognitive dysfunction” OR “cognitive disorder” OR “cognitive disorders”) | 97 |
CAPES Theses and Dissertations | (Queda OR Quedas) AND Idoso AND Sarcopenia | 29 |
Networked Digital Library of Theses and Dissertations (NDLTD) | (“Accidental Falls”) AND (Aged) AND (Sarcopenia) | 38 |
EBSCO Open Dissertations | (“Accidental Falls”) AND (Aged) AND (Sarcopenia) | 51 |
DART-e | (Fall OR Falls) AND (Aged) AND (Sarcopenia) | 3 |
Brazilian Digital Library of Theses and Dissertations | (Fall OR Falls) AND (Aged) AND (Sarcopenia) | 18 |
ACS Guide to Scholarly Communication | (Fall OR Falls) AND (Aged) AND (Sarcopenia) | 13 |
Total Records | 439 |
Author, Year | Population | Age, Sex | Type of Study | Instruments | Prevalence |
---|---|---|---|---|---|
Santos, 2021 [23] | 413 elderly patients receiving care at the geriatrics and gerontology outpatient unit | ≥60 years old, of both sexes, with a prevalence of females | Cross-sectional | EWGSOP2 criteria *** (handgrip strength—SAEHAN digital dynamometer, Gait Speed Test, Body Mass Index) Report of falls over the last 3 months Mini Mental State Examination (MMSE) | Sarcopenia - Probable: 57.9% - Confirmed: 6.1% - Severe: 6.8% Falls: 18.4% Cognitive Impairment: 25.7% |
Lee et al., 2021 [24] | 2028 elderly outpatients | ≥70 years, of both sexes | Retrospective longitudinal | AWGS Criteria * 2014 and 2019 (Dual-energy X-ray absorptiometry, digital handgrip dynamometer, usual gait speed of 4 m) Report of falls over the last 12 months MMSE | Sarcopenia: 17.5% (AWGS 2019) 9.1% (AWGS 2014) Falls: 23.1% of elderly people with sarcopenia Cognitive Impairment: 24.1% |
Xu et al., 2020 [25] | 582 elderly people from the community | ≥80 years, of both sexes, with a prevalence of females | Cross-sectional | AWGS Criteria * (Handgrip strength—dynamometer, usual gait speed, electrical bioimpedance) Report of falls over the last 12 months Montreal Cognitive Assessment (MoCA) | Sarcopenia: 26.6% Falls: 18.1% Cognitive Impairment: 60.8% |
Landi et al., 2012 [26] | 260 elderly people from the community | ≥80 years, of both sexes, with a prevalence of female | Prospective longitudinal | EWGSOP Criteria ** (middle arm muscle circumference, usual gait speed, handgrip strength—dynamometer) Report of falls within 24 months of follow-up Minimum Data Set for Home Care (MDS-HC) | Sarcopenia: 25.4% Falls: 14.2% Cognitive Impairment: 14.2% |
Author | Association Measurement | p-Value |
---|---|---|
Santos, 2021 [23] | OR 1.333 (0.372–4.775) | 0.658 |
Lee et al., 2021 [24] | - | <0.001 |
Xu et al., 2020 [25] | OR 2.00 (1.17–3.43) | - |
Landi et al., 2012 [26] | HR 3.23(1.25–8.29) | - |
Studies | Q1 | Q2 | Q3 | Q4 | Q5 | Q6 | Q7 | Q8 |
---|---|---|---|---|---|---|---|---|
Santos, 2021 [24] | Y | Y | Y | Y | N | N | Y | N |
Xu et al., 2020 [26] | Y | Y | Y | Y | Y | Y | Y | Y |
Total % | 100% | 100% | 100% | 100% | 50% | 50% | 100% | 50% |
Studies | Q1 | Q2 | Q3 | Q4 | Q5 | Q6 | Q7 | Q8 | Q9 | Q10 | Q11 |
---|---|---|---|---|---|---|---|---|---|---|---|
Lee et al., 2021 [25] | Y | Y | Y | Y | Y | Y | Y | P | Y | NP | Y |
Landi et al., 2012 [27] | Y | Y | Y | Y | Y | Y | P | Y | Y | NP | Y |
Total % | 100% | 100% | 100% | 100% | 100% | 100% | 50% | 50% | 100% | 0% | 100% |
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Fhon, J.R.S.; Silva, A.R.F.; Lima, E.F.C.; Santos Neto, A.P.d.; Henao-Castaño, Á.M.; Fajardo-Ramos, E.; Püschel, V.A.A. Association between Sarcopenia, Falls, and Cognitive Impairment in Older People: A Systematic Review with Meta-Analysis. Int. J. Environ. Res. Public Health 2023, 20, 4156. https://doi.org/10.3390/ijerph20054156
Fhon JRS, Silva ARF, Lima EFC, Santos Neto APd, Henao-Castaño ÁM, Fajardo-Ramos E, Püschel VAA. Association between Sarcopenia, Falls, and Cognitive Impairment in Older People: A Systematic Review with Meta-Analysis. International Journal of Environmental Research and Public Health. 2023; 20(5):4156. https://doi.org/10.3390/ijerph20054156
Chicago/Turabian StyleFhon, Jack Roberto Silva, Alice Regina Felipe Silva, Eveline Fontes Costa Lima, Alexandre Pereira dos Santos Neto, Ángela Maria Henao-Castaño, Elizabeth Fajardo-Ramos, and Vilanice Alves Araújo Püschel. 2023. "Association between Sarcopenia, Falls, and Cognitive Impairment in Older People: A Systematic Review with Meta-Analysis" International Journal of Environmental Research and Public Health 20, no. 5: 4156. https://doi.org/10.3390/ijerph20054156