The Combination of Hearing Impairment and Frailty Is Associated with Cognitive Decline among Community-Dwelling Elderly in Japan
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Measurements
2.2.1. Cognitive Decline
2.2.2. Frailty Status
2.2.3. Hearing Impairment
2.2.4. Confounding Factors
2.3. Statistical Analysis
2.4. Ethical Considerations
3. Results
3.1. Characteristics of Participants
3.2. Relationships of Cognitive Decline with Hearing Difficulty and Frailty
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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All Sample | Cognition | p Value * | |||
---|---|---|---|---|---|
n = 464 | Normal (n = 446) | Decline (n = 18) | |||
Age (y) | Mean (SD) | 76.3 (6.0) | 76.1 (6.0) | 79.4 (7.6) | 0.026 |
≥75 y | Number (%) | 258 (55.6) | 246 (55.2) | 12 (66.7) | 0.471 |
Body mass index (kg/m2) | Mean (SD) | 22.4 (3.1) | 22.4 (3.1) | 23.1 (3.0) | 0.309 |
Sex (female) | Number (%) | 280 (60.3) | 273 (61.8) | 7 (38.9) | 0.089 |
Financial situation (poor) | Number (%) | 106 (22.8) | 99 (22.3) | 7 (38.9) | 0.177 |
Living arrangement (alone) | Number (%) | 144 (31.0) | 142 (31.8) | 2 (11.1) | 0.109 |
Social isolation (<12 points in 6LSNS) | Number (%) | 171 (36.9) | 159 (37.2) | 12 (75.0) | 0.005 |
Number of social activities (0–6 type) | Mean (SD) | 1.9 (1.7) | 1.9 (1.7) | 0.7 (1.6) | 0.004 |
Subjective health (poor) | Number (%) | 122 (26.3) | 112 (25.3) | 10 (55.6) | 0.01 |
Medical history: Hypertension | Number (%) | 213 (45.9) | 205 (46.0) | 8 (44.4) | >0.99 |
Medical history: Diabetes mellitus | Number (%) | 70 (15.1) | 65 (14.6) | 5 (27.8) | 0.231 |
Medical history: Cerebrovascular disease | Number (%) | 5 (1.1) | 4 (0.9) | 1 (5.6) | 0.476 |
Polypharmacy (≥5 types of prescribed medicines) | Number (%) | 88 (19.0) | 81 (19.2) | 7 (38.9) | 0.082 |
Nutritional intake status (good) | Number (%) | 265 (57.1) | 256 (58.6) | 9 (50.0) | 0.631 |
Hearing impairment (1–5 points) | Mean (SD) | 1.8 (0.8) | 1.8 (0.8) | 3.0 (0.8) | <0.001 |
The score of KCL (0–25 points) | Mean (SD) | 5.0 (3.8) | 4.7 (3.5) | 11.8 (5.5) | <0.001 |
Pre-frailty | Number (%) | 167 (36.0) | 164 (38.0) | 3 (16.7) | <0.001 |
Frail | Number (%) | 100 (21.6) | 86 (19.9) | 14 (77.8) | |
SDC score (10–40 points) | Mean (SD) | 12.7 (2.7) | |||
Cognitive decline (≥18 points in SDC) | Number (%) | 18 (3.9) |
Variables | OR | 95% C.I. | p Value |
---|---|---|---|
Age (y) | 1.03 | 0.92–1.15 | 0.6370 |
Body mass index (kg/m2) | 1.23 | 0.97–1.56 | 0.0862 |
Sex (female) | 0.65 | 0.13–3.16 | 0.5930 |
Financial status (poor) | 0.74 | 0.17–3.26 | 0.6900 |
Living arrangement (alone) | 0.27 | 0.04–2.00 | 0.1990 |
Social isolation (<12 points in 6LSNS) | 1.55 | 0.29–8.39 | 0.6080 |
Number of social activities (0–6 types) | 0.66 | 0.37–1.18 | 0.1650 |
Subjective health (poor) | 0.54 | 0.11–2.68 | 0.4490 |
Medical history: Hypertension | 1.04 | 0.23–4.65 | 0.9600 |
Medical history: Diabetes mellitus | 1.58 | 0.30–8.22 | 0.5860 |
Medical history: Cerebrovascular disease | 3.42 | 0.08–146.00 | 0.5210 |
Polypharmacy (≥5 types of prescribed medicines) | 1.20 | 0.28–5.27 | 0.8050 |
Nutritional intake status: Food diversity (good) | 0.83 | 0.21–3.29 | 0.7910 |
Hearing impairment (1 point increase) | 4.09 | 1.85–9.03 | 0.0005 |
Frailty status | |||
Robust | 1.00 | ||
Pre-frailty | 1.62 | 0.10–25.70 | 0.7340 |
Frailty | 20.40 | 1.48–280.00 | 0.0242 |
Variables | OR | 95% C.I. | p Value |
---|---|---|---|
Age (y) | 1.04 | 0.92–1.17 | 0.5340 |
Body mass index (kg/m2) | 1.25 | 0.99–1.58 | 0.0636 |
Sex (female) | 0.54 | 0.11–2.57 | 0.4380 |
Financial status (poor) | 0.70 | 0.15–3.18 | 0.6460 |
Living arrangement (alone) | 0.26 | 0.03–1.95 | 0.1890 |
Social isolation (<12 points in 6LSNS) | 1.67 | 0.32–8.70 | 0.5450 |
Number of social activities (0–6 types) | 0.68 | 0.39–1.20 | 0.1860 |
Subjective health (poor) | 0.60 | 0.11–3.20 | 0.5480 |
Medical history: Hypertension | 1.02 | 0.22–4.68 | 0.9750 |
Medical history: Diabetes mellitus | 1.84 | 0.36–9.39 | 0.4620 |
Medical history: Cerebrovascular disease | 2.04 | 0.05–83.00 | 0.7070 |
Polypharmacy (≥5 types of prescribed medicines) | 1.26 | 0.28–5.61 | 0.7630 |
Nutritional intake status: Food diversity (good) | 0.82 | 0.21–3.22 | 0.7800 |
Interaction term | |||
Hearing impairment: Robust | 2.57 | 0.83–7.96 | 0.1010 |
Hearing impairment: Pre-frailty | 2.74 | 1.24–6.03 | 0.0125 |
Hearing impairment: Frailty | 6.20 | 2.54–15.10 | 0.0001 |
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Kawamura, A.; Kamide, N.; Ando, M.; Murakami, T.; Shahzad, M.T.; Takahashi, K. The Combination of Hearing Impairment and Frailty Is Associated with Cognitive Decline among Community-Dwelling Elderly in Japan. Int. J. Environ. Res. Public Health 2023, 20, 4437. https://doi.org/10.3390/ijerph20054437
Kawamura A, Kamide N, Ando M, Murakami T, Shahzad MT, Takahashi K. The Combination of Hearing Impairment and Frailty Is Associated with Cognitive Decline among Community-Dwelling Elderly in Japan. International Journal of Environmental Research and Public Health. 2023; 20(5):4437. https://doi.org/10.3390/ijerph20054437
Chicago/Turabian StyleKawamura, Akie, Naoto Kamide, Masataka Ando, Takeshi Murakami, Machiko T. Shahzad, and Kayoko Takahashi. 2023. "The Combination of Hearing Impairment and Frailty Is Associated with Cognitive Decline among Community-Dwelling Elderly in Japan" International Journal of Environmental Research and Public Health 20, no. 5: 4437. https://doi.org/10.3390/ijerph20054437