Literary Identification of Differentially Hydroxymethylated DNA Regions for Type 2 Diabetes Mellitus: A Scoping Minireview
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Strategy for Evidence
2.2. Evidence Selection Criteria
- (1)
- Original research studies that might include quantitative, qualitative, and mixed methods, observational studies, interventions, randomized trials, and experiments.
- (2)
- Studies that included type 2 diabetes patients as the primary subjects but might have animals in addition to human subjects.
- (3)
- Studies were published on PubMed prior to 1 August 2022, as the initial search was conducted between 1 June and 1 August 2022 for the required concept areas.
- (4)
- Studies are written in the English language.
- (5)
- Studies that addressed DNA hydroxymethylation and its relation to T2DM.
- (6)
- Studies that had comparisons to healthy or non-diabetic reference groups.
2.3. Evidence Assessment
2.4. Reviewer Protocol
- a.
- If the second reviewer withdrew after completing a section of the review, the completed portion would be included and compared to that of the other independent reviewer.
- b.
- If the second reviewer withdrew prior to completing a section of the review, the work in progress would be excluded, and an additional independent reviewer should be brought in.
- c.
- If an additional second reviewer was unable to be obtained within the constraints, the scoping review could be completed based on the results of a single reviewer.
2.5. Data Extraction
2.6. Summarizing and Reporting
2.7. Ethics and Dissemination
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Search | Source Title | Author |
---|---|---|
MeSH | Alterations of 5-hydroxymethylcytosines in circulating cell-free DNA reflect retinopathy in type 2 diabetes. | Han et al. [23] |
5-Hydroxymethylcytosines in Circulating Cell-Free DNA Reveal Vascular Complications of Type 2 Diabetes. | Yang et al. [24] | |
Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs. ** | Yuan et al. [21] | |
PubMed Keyword search | Alterations of 5-hydroxymethylcytosines in circulating cell-free DNA reflect retinopathy in type 2 diabetes. | Han et al. [23] |
Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus. * | Zampieri et al. [22] | |
5-Hydroxymethylcytosines in Circulating Cell-Free DNA Reveal Vascular Complications of Type 2 Diabetes. | Yang et al. [24] | |
Effect of diabetes status and hyperglycemia on global DNA methylation and hydroxymethylation. * | Pinzon-Cortes et al. [20] | |
Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs. ** | Yuan et al. [21] | |
DNA modifications: function and applications in normal and disease States. | Liyanage et al. [25] | |
5-Hydroxymethylcytosine Remodeling Precedes Lineage Specification during Differentiation of Human CD4(+) T Cells. | Nestor et al. [26] | |
Genome-wide Analysis Reflects Novel 5-Hydroxymethylcytosines Implicated in Diabetic Nephropathy and the Biomarker Potential. | Yang et al. [27] | |
Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA Hydroxymethylation and TET Proteins. | Pirola et al. [28] | |
Machine-learning to stratify diabetic patients using novel cardiac biomarkers and integrative genomics. | Hathaway et al. [29] | |
Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome. | Johnson et al. [30] | |
Stable Oxidative Cytosine Modifications Accumulate in Cardiac Mesenchymal Cells From Type 2 Diabetes Patients: Rescue by α-Ketoglutarate and TET-TDG Functional Reactivation. | Spallota et al. [31] |
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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Luong, R.A.M.; Guan, W.; Vue, F.C.; Dai, J. Literary Identification of Differentially Hydroxymethylated DNA Regions for Type 2 Diabetes Mellitus: A Scoping Minireview. Int. J. Environ. Res. Public Health 2024, 21, 177. https://doi.org/10.3390/ijerph21020177
Luong RAM, Guan W, Vue FC, Dai J. Literary Identification of Differentially Hydroxymethylated DNA Regions for Type 2 Diabetes Mellitus: A Scoping Minireview. International Journal of Environmental Research and Public Health. 2024; 21(2):177. https://doi.org/10.3390/ijerph21020177
Chicago/Turabian StyleLuong, Ryan Anh Minh, Weihua Guan, Fue Chee Vue, and Jun Dai. 2024. "Literary Identification of Differentially Hydroxymethylated DNA Regions for Type 2 Diabetes Mellitus: A Scoping Minireview" International Journal of Environmental Research and Public Health 21, no. 2: 177. https://doi.org/10.3390/ijerph21020177