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Current Oncology
Volume 26
Issue 6
10.3747/co.26.5225
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Recurrence and Mortality after Breast-Conserving Surgery without Radiation

by
K. Guidolin
1,2,*,
M. Lock
3,4,
K. Vogt
3,4,
J. A. McClure
5,
J. Winick-Ng
5,
C. Vinden
3,4,5 and
M. Brackstone
3,4
1
MaRS Centre, Princess Margaret Cancer Centre, 101 College Street, Room 5-535, Toronto, ON M5G 1L7, Canada
2
Department of Surgery, University of Toronto, Toronto, ON, Canada
3
Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
4
London Health Sciences Centre, London, ON, Canada
5
ICES, London, ON, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2019, 26(6), 380-388; https://doi.org/10.3747/co.26.5225
Submission received: 5 September 2019 / Revised: 4 October 2019 / Accepted: 2 November 2019 / Published: 1 December 2019

Abstract

Background: Breast-conserving surgery (BCS) and radiation therapy (RT) are the standard of care for early breast cancer; studies have demonstrated that adjuvant RT confers a protective effect with respect to recurrence, although no randomized trials have shown a survival benefit. Methods: This retrospective cohort study used Ontario data linked through ICES to examine patients treated for breast cancer between 1 April 2007 and 31 March 2014. The primary outcome was death or recurrence. Outcomes were compared between patients who did and did not receive RT. Results: The total cohort size was 26,279. The hazard ratios (HRS) for various outcomes were significantly higher for patients who did not receive RT than for patients who did: recurrence or death combined [HR: 2.49; 95% confidence interval (CI): 2.25 to 2.75], recurrence (HR: 2.33; 95% CI: 1.91 to 2.84), and death (HR: 2.28; 95% CI: 2.03 to 2.56). The HR for death was 1.81 (95% CI: 1.65 to 1.99) for patients having stage II cancer compared with those having stage I disease. The HR for death was 1.97 (95% CI: 1.74 to 2.22) for patients having high comorbidity compared with those having little comorbidity. Conclusions: Adjuvant RT carries a protective effect with respect to recurrence and survival in patients with early-stage breast cancer. That survival benefit has not been appreciated in previous randomized trials and underscores the importance of rt as a component of breast cancer treatment.
Keywords: breast cancer; radiation therapy; death; recurrence; breast-conserving therapy breast cancer; radiation therapy; death; recurrence; breast-conserving therapy

Share and Cite

MDPI and ACS Style

Guidolin, K.; Lock, M.; Vogt, K.; McClure, J.A.; Winick-Ng, J.; Vinden, C.; Brackstone, M. Recurrence and Mortality after Breast-Conserving Surgery without Radiation. Curr. Oncol. 2019, 26, 380-388. https://doi.org/10.3747/co.26.5225

AMA Style

Guidolin K, Lock M, Vogt K, McClure JA, Winick-Ng J, Vinden C, Brackstone M. Recurrence and Mortality after Breast-Conserving Surgery without Radiation. Current Oncology. 2019; 26(6):380-388. https://doi.org/10.3747/co.26.5225

Chicago/Turabian Style

Guidolin, K., M. Lock, K. Vogt, J. A. McClure, J. Winick-Ng, C. Vinden, and M. Brackstone. 2019. "Recurrence and Mortality after Breast-Conserving Surgery without Radiation" Current Oncology 26, no. 6: 380-388. https://doi.org/10.3747/co.26.5225

APA Style

Guidolin, K., Lock, M., Vogt, K., McClure, J. A., Winick-Ng, J., Vinden, C., & Brackstone, M. (2019). Recurrence and Mortality after Breast-Conserving Surgery without Radiation. Current Oncology, 26(6), 380-388. https://doi.org/10.3747/co.26.5225

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