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Current Oncology
Volume 29
Issue 11
10.3390/curroncol29110650
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Review
Peer-Review Record

Olanzapine for the Prevention and Treatment of Chemotherapy-Induced Nausea and Vomiting: A Review to Identify the Best Way to Administer the Drug

Curr. Oncol. 2022, 29(11), 8235-8243; https://doi.org/10.3390/curroncol29110650
by Xiao-Ling Zhang 1 and Jie-Er Ying 2,*
Reviewer 1:
Naotake Funamizu
Reviewer 2: Anonymous
Curr. Oncol. 2022, 29(11), 8235-8243; https://doi.org/10.3390/curroncol29110650
Submission received: 6 October 2022 / Revised: 23 October 2022 / Accepted: 25 October 2022 / Published: 31 October 2022
(This article belongs to the Section Palliative and Supportive Care)

Round 1

Reviewer 1 Report

The authors reviewed the antiemetic effect of olanzapine from the antiemetic mechanism, dose, and administration time.

Questions and opinions from the reviewer

1. Reference is really insufficient considering the review article.

2. In Japan, 5mg and administration after dinner are recommended. Please discuss this in addition following clinical trial " Lancet Oncol. 2020 Feb;21(2):242-249".  ã€€

3. The indication of olanzapine should be discussed more including use alone or which type of HEC.  

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

In my point of view, the manuscript is a rather well written comprehensive review of this particular field. Treatment side effects in oncology is a very important topic on the whole, as far as chemotherapy is becoming more and more effective in most types of cancers.  Nausea and vomiting are among the most common chemotherapy side effects therefore this review manuscript concentrates on a currently important problem. The main drawbacks of the manuscript - not very precise and clear tables; lack of innovation as far as it is a review manuscript. Recommend for review and reconsideration afterwards.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

The authors revised according to reviewer comments. This manuscript will be worthy to accept.

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