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Case Report
Peer-Review Record

Growing Teratoma Syndrome in the Setting of Sarcoidosis: A Case Report and Literature Review

Curr. Oncol. 2022, 29(6), 4148-4154; https://doi.org/10.3390/curroncol29060331
by Adel Shahnam 1,*, Robyn Sayer 2, Unine Herbst 3, Raghwa Sharma 4, Won-hee Yoon 1, Tim Dinihan 5 and Bo Gao 1,*
Reviewer 1: Anonymous
Reviewer 2:
Curr. Oncol. 2022, 29(6), 4148-4154; https://doi.org/10.3390/curroncol29060331
Submission received: 23 March 2022 / Revised: 30 May 2022 / Accepted: 6 June 2022 / Published: 7 June 2022

Round 1

Reviewer 1 Report

Interesting case report and review of the literature. Not innovative.

minor typos: i.e. line28 mesodermal, line 32 APF, line 61 sampingo, line 189  multiple disciplinary

Author Response

see attached

Author Response File: Author Response.pdf

Reviewer 2 Report

Thank you for this interesting case report. It emphasizes very well the need for multidisciplinary tumor boards by characterizing the risk of over- and under-treatment.

A few comments though:

Spelling: Line 132 deferential => differential

Line 154 PDG => FDG 

Discussion:

Line 175-188: Sarcoidosis or Sarcoid like lesions represent a known challange in patients with cancer. You might want to add, that a core needle biopsie should be the gold standard to secure a malignant diagnosis. See  case series: Eggers et al.  Oncol Res Treat 2019;42:382–386 

General remarks:

Why was third surgery performed extensively including splenectomy? Did you discuss further biopsy of low and high FDG-avid leasion before?

Following these thoughts, you might be able to be more specific to define "adequate tissue diagnostic" in you conclusion. I would suggest that a biopsy should be preferred whenever possible to prevent overtreatment.   

Author Response

see attached

Author Response File: Author Response.pdf

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