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Current Oncology
Volume 30
Issue 10
10.3390/curroncol30100673
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Article
Peer-Review Record

Erectile Dysfunction Is Common after Rectal Cancer Surgery: A Cohort Study

Curr. Oncol. 2023, 30(10), 9317-9326; https://doi.org/10.3390/curroncol30100673
by Sebastian Borgund Hansen 1,2,*, Birthe Thing Oggesen 2, Siv Fonnes 1 and Jacob Rosenberg 1,2
Reviewer 1:
Hongjun Li
Reviewer 2:
Jeroen C. Hol
Curr. Oncol. 2023, 30(10), 9317-9326; https://doi.org/10.3390/curroncol30100673
Submission received: 25 August 2023 / Revised: 26 September 2023 / Accepted: 20 October 2023 / Published: 20 October 2023
(This article belongs to the Section Surgical Oncology)

Round 1

Reviewer 1 Report

My major concerns are as follows:

1. The sample size was a little bit small (67 cases) due to limited research time (4 years) and single-center cohort study. This limitation should be mentioned in paper.

2. In table 3, 10 patients (16%) no erectile dysfunction with IIEF-5 scores 22–25 and 47 (76%) Severe erectile dysfunction with IIEF-5 scores 1–7. The authors should discuss the results in discussion part concerning the extreme situations.

3. Considering the prevalence of ED, the safe methods for treatment of rectal cancer were in turn chemotherapy alone, robot-assisted, no chemoradiotherapy before or after surgery, radiotherapy with/without chemotherapy, open and converted operations and laparoscopic. To make the research more meaningful, the results can be discussed in detail.

4. Erectile function can improve over time, and many researchers try to explore the effective methods to facilitate the improvement, such as earlier intervention or usage of PED-5 inhibitors after surgery. The authors should give proper discussion.

5. To understand the process for natural recovery of ED, more observation time is needed and encouraged for future research.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

Thank you for the opportunity to review “Erectile dysfunction is common after rectal cancer surgery:a cohort study” by Hansen et al. This is a retrospective study using the IIEEF questionnaire to investigate the prevalence of erectile dysfunction after rectal cancer surgery. The overall number of patients (N=101) seems rather low. Erectile dysfunction is a known complication after rectal cancer study. The prevalence depends on patient selection. This makes is hard to see what this study exactly adds to the current literature.

What is a late complication clinic? Is this a selected group of patients?

What was time from surgery to questionnaire?

Were other functional outcomes also measured? For example quality of life. Did the IIEEF scores related to lower quality of life?

Needs minor spell check. 

Author Response

Please see attachment.

Author Response File: Author Response.pdf

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