Update on Locoregional Therapies for Liver Cancer: Radiation Segmentectomy

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

Title: “Update on locoregional therapies for liver cancer: radiation segmentectomy”. What this review attempted to do Ablation, transarterial chemoembolization (TACE), transarterial radioembolization (TARE), surgery, liver transplantation, ablation, and intra-arterial therapies are all used to treat HCC. Radiation segmentectomy is also used as a curative treatment for very early to early stage HCC that is undetectable and not amenable to ablation. This review is accepted in this form. Mention figures in the text.

 

Author Response

Thank you very much for your thoughtful feedback. Figures have been adjusted to be mentioned within the text. 

Author Response File: Author Response.pdf

Reviewer 2 Report

Comments and Suggestions for Authors

 

Dear Authors,

The present manuscript titled ‟ Update on Locoregional Therapies for Liver Cancer: Radiation 2 Segmentectomy” authors discussed various therapies available for hepatocellular carcinoma (HCC) and their shortcomings. Authors provided a new therapeutic approach using radiation segmentectomy as curative treatment for very early to early stage HCC. The present manuscript enhance the  understanding and exploring the radiation segmentectomy for HCC.  

Minor Comment:

1.       A summary table or graphical representation of very early to early stage HCC and therapeutic methods would provide a quick understanding to readers.

Author Response

Thank you for your thoughtful feedback! I have added a table to the manuscript in order to summarize the text in a more concise format. Please see Table 2 on page 5. 

Author Response File: Author Response.pdf

Reviewer 3 Report

Comments and Suggestions for Authors

This is a review dealing with the role of SIRT for HCC. 
I have some comments:

MAJOR:

- The first part of your manuscript is well written with a deep analysis of the different studies with the conclusion of dose-related efficacy of this treatment. On the other hand, the second part ("How to navigate BCLC 0-A" and "Non-HCC lesion") is very poor.
You have to consider, explain and cite the different studied on advanced HCC (es. SARAH, SORAMIC, SIRveNIB, fist data on immunotherapy), the role of SIRT as conversion therapy, and so on.
The present version of your manuscript is a review on the evolving scenario of SIRT dose-finding and not an update on locoregional therapies.

MINOR:

- affiliations are not in the style of the journal

- line 33: according to different guidelines, the typical arterial hyper-enhancement and washout is sufficient for the non-invasive diagnosis of HCC in cirrhotic patients regardless of their bleeding risk. You should correct it.

- line 49: in the Child-Pugh score there is also the item "encephalopathy"

Comments on the Quality of English Language

there are some typos and grammar errors. Please revise them.

Author Response

Thank you very much for your thoughtful feedback! 

"The first part of your manuscript is well written with a deep analysis of the different studies with the conclusion of dose-related efficacy of this treatment. On the other hand, the second part ("How to navigate BCLC 0-A" and "Non-HCC lesion") is very poor.
You have to consider, explain and cite the different studied on advanced HCC (es. SARAH, SORAMIC, SIRveNIB, fist data on immunotherapy), the role of SIRT as conversion therapy, and so on.
The present version of your manuscript is a review on the evolving scenario of SIRT dose-finding and not an update on locoregional therapies."

• The focus of the review is radiation segmentectomy rather than SIRT as a whole

"Affiliations are not in the style of the journal"

• These have been updated.

"line 33: according to different guidelines, the typical arterial hyper-enhancement and washout is sufficient for the non-invasive diagnosis of HCC in cirrhotic patients regardless of their bleeding risk. You should correct it."

• This has been corrected.

"line 49: in the Child-Pugh score there is also the item "encephalopathy""

• This has been updated.

"There are some typos and grammar errors. Please revise them."

• The manuscript has been further proofread.

Thank you again. 

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

Comments and Suggestions for Authors

Dear Authors,

Thank you for modifications and addressing my concerns.

Reviewer 3 Report

Comments and Suggestions for Authors

ok

Comments on the Quality of English Language

ok