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Review

Young Myeloma Patients: A Systematic Review of Manifestations and Outcomes

by
Mégane Tanguay
1,2,
Christophe Dagenais
2,3,
Richard LeBlanc
1,2,
Imran Ahmad
1,2,
Jean-Sébastien Claveau
1,2 and
Jean Roy
1,2,*
1
Institut Universitaire d’Hémato-Oncologie et de Thérapie Cellulaire, Hôpital Maisonneuve-Rosemont, 5415 de l’Assomption, Montreal, QC H1T 2M4, Canada
2
Departement of Medicine, Université de Montréal, 2900 Édouard-Montpetit, Montreal, QC H3T 1J4, Canada
3
Service de Médecine Interne, Hôpital Notre-Dame, 1560 Sherbrooke Est, Montreal, QC H2L 4M1, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2023, 30(6), 5214-5226; https://doi.org/10.3390/curroncol30060396
Submission received: 20 April 2023 / Revised: 15 May 2023 / Accepted: 18 May 2023 / Published: 23 May 2023
(This article belongs to the Special Issue New Frontiers in Pathogenesis, Diagnosis, Prognosis and Treatment for Multiple Myeloma)
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Abstract

:
Multiple myeloma usually affects older adults. However, younger patients constitute a significant subset as approximately 10% of cases occur in subjects younger than 50 years old. Young patients, who are underrepresented in the literature, are diagnosed during their most productive years of life, urging the need for tailored treatment approaches. This literature review aims to report recent studies specifically addressing young patients with a focus on characteristics at diagnosis, cytogenetics, treatments, and outcomes. We searched PubMed for studies involving young patients with multiple myeloma ≤50 years old. The time span of our literature review search was from 1 January 2010 to 31 December 2022. Overall, 16 retrospective studies were analyzed for this review. Young patients with multiple myeloma tend to have less advanced disease, more frequent light chain subtypes, and survive longer compared to their older counterparts. However, available studies included a limited number of patients; the newest revised international staging system was not used to stratify patients, cytogenetics varied from one cohort to another, and most patients did not receive contemporary triplet/quadruplet treatments. This review emphasizes the need to perform contemporary, large-scale retrospective studies to improve knowledge regarding the presentation and outcomes of young myeloma patients in the era of modern treatments.

1. Introduction

Despite several therapeutic advances in recent years, multiple myeloma (MM) remains a mostly incurable disease. The aims of current treatments are to relieve symptoms, reverse or avoid organ damage, improve quality of life, and prolong survival. The disease specifically affects older adults, with a median age at diagnosis of about 70 years [1,2]. Nevertheless, younger patients constitute a significant subset as approximately 10% of all cases occur in subjects younger than 50 years old [3]. The average years of life lost per patient is as high as 36 years for patients under 40 years and reaches up to 27 years for patients between the ages of 40 to 49 years. In contrast, the entire myeloma population loses 16.8 years of life on average to the disease [4]. In addition to a significantly shorter life expectancy, young patients are affected in their most productive years professionally and suffer a significant deterioration in their quality of life due to the disease [5].
Young myeloma patients are underrepresented in the literature, with small numbers buried in cohorts of older patients in clinical trials testing novel therapies. Few studies have specifically addressed their clinical characteristics and outcomes in recent years. Most are case reports or small cohorts spanning over several years, with only a minority of studies including a significant number of patients treated with contemporary regimens. Young patients with MM tend to better tolerate treatments with less therapy discontinuation or dose reductions, emphasizing that this unique subpopulation requires a tailored approach to treatment [6]. We believe there is a need to further understand the disease biology and optimal treatments in this younger subgroup. This literature review aims to report available studies specifically addressing young myeloma patients and underline the needs and shortcomings surrounding them with a focus on four aspects: patients’ characteristics at diagnosis, cytogenetics, treatments administered, and outcomes.

2. Methods

We searched PubMed for studies involving MM in young patients (see Figure 1 and Figure 2 for search strategies).
Owing to the lack of consensus on the definition of young patients, we elected, for the purpose of this review, to define them as ≤50 years old. The time span of our literature review search was from 1 January 2010 to 31 December 2022. We restricted the search to the last 12 years to include patients treated with novel therapies and risk stratified using the newest prognostic scores. PubMed was used to retrieve studies involving patients ≤50 years old. As shown in Figure 1, 226 studies were initially identified. Studies unrelated to MM, case reports, studies including only patients over 50 years, and studies in languages other than English were excluded.
The search strategy was developed by 2 reviewers (CD and MT), who screened the title and the abstract while creating a shortlist of studies for further evaluation. If a decision on inclusion was not possible on this basis, we obtained the full text of the article to assess eligibility. Disagreement in study selection was resolved through mutual discussion and consensus with a third author (JR). To increase the data concerning patient characteristics, three articles that included large cohorts of young patients were added to the analysis even if they were published prior to 2010 [7,8,9]. Overall, 16 retrospective studies were analyzed in this review.
Studies were classified into two groups based on the presence or absence of an older age group comparator. Different tables were created to collect relevant information: patients’ characteristics, cytogenetics, treatments, and outcomes. The patients’ characteristics from all 16 studies are available in Table 1 and Table 2. Non-secretory myeloma patients were not included in our analysis because they were rarely reported. Cytogenetic data were available in 11 studies (Table 3). More modern publications were included in the treatments and outcomes to focus on young patients treated with contemporary regimens. Only articles disclosing the 5-year overall survival (OS) or progression-free survival (PFS) were included to better highlight the long-term impact of MM in young patients, therefore 8 studies were retained in Table 4. Data on consolidation and maintenance were not consistently reported and therefore were not included.

3. Results

3.1. Disease Characteristics at Diagnosis

Characteristics at initial diagnosis including patients’ age, International Staging System (ISS), disease features, M protein isotype, and cytogenetics are presented in Table 1, Table 2 and Table 3. Overall, disease characteristics at diagnosis in the different studies were quite similar in terms of clinical and laboratory data. However, two factors seem to stand out in young patients: the light chain MM and ISS 1 subgroup.
While the incidence of light chain disease is approximately 15% in the general myeloma population [23], studies including only young patients have reported incidences ranging from 19 to 45% in patients ≤ 50 years [7,10,13,14,15,16,17], with only one study with a lower incidence of 11% [12]. Similarly, all studies comparing young and older patients have shown a higher proportion of light chain MM, including Corso et al. (<50 years: 12% vs. ≥50 years: 8%), Ludwig et al. (<50 years: 13% vs. ≥50 years: 10%, p = 0.002), Lu et al. (<50 years: 33% vs. ≥50 years 26%, p = 0.057), Dhakal et al. (≤50 years: 30% vs. >70 years: 18%), Nakaya et al. (<40 years: 33% vs. all patients: 16%, p = 0.021), and Pydi et al. (<40 years: 41% vs. all patients: 33%) [8,9,18,20,21,22].
Approximately 25% of all MMs are in the ISS 1 subgroup [16,24]. In some studies without an older age group comparator included in this review, a higher proportion of ISS 1 was reported, ranging from 32 to 68% [10,11,13,14,15,16,17]. One study reported a lower ISS 1 incidence of 13% [12]. Similarly, among studies comparing age groups, three reported a higher proportion of ISS 1 in younger patients including Ludwig et al. (<50 years: 36% vs. ≥50 years: 26%, p < 0.001), Lu et al. (<50 years: 30% vs. ≥50 years: 17%, p < 0.001), and Nakaya et al. (<40 years: 43% vs. all patients: 23%, p = 0.019) [9,18,21].
It remains unclear whether young patients diagnosed with MM have an increased incidence of a familial history of MM or secondary hematological malignancies. In Altieri et al.’s database study, the age at diagnosis of familial cases was lower compared to sporadic cases [25]. As per Vachon et al., there was an increased risk of MGUS (monoclonal gammopathy of undetermined significance) in first-degree relatives of probands with MGUS and MM. This increased prevalence was seen across all ages of relatives ≥ 40 years old [26]. In Clay-Gilmour et al.’s study, the familial risk of MGUS remained consistent regardless of the age at which the proband was diagnosed [27].

3.2. Cytogenetics

Table 3 highlights the different cytogenetic abnormalities of 11 recent studies included in this review. There is great heterogeneity in abnormalities tested and reported. For instance, Duek et al. reported t(11;14) in up to 68% of their young MM cohort (<50 years old) [15], which is much higher than the expected 15–20% found in the MM population [3,28]. As shown in Caulier et al.’s cohort, del (17p) and/or t(4;14) were present in 18% of their young patients (<40) and were a predictor of poor OS [16]. Jurczyszyn et al. found that patients aged 21–40 years had a higher prevalence of high-risk cytogenetics (del (17p) and t(4;14)) compared to patients 41–60 years old (32% vs. 17%, p = 0.007) [19]. Nakaya et al. also found a higher frequency of del (17p) in patients < 40 compared to the entire myeloma cohort (33% vs. 14% p = 0.008) [21]. In contrast, studies by Lu and Ludwig have observed similar frequencies of different clonal cytogenetic abnormalities [9,18].

3.3. Treatments and Outcomes

Treatments and outcomes are shown in Table 4. Patients included were treated over a span of several years, drugs used for induction were reported inconsistently, and older regimens were of common occurrence. Studies reporting induction treatments with a combination of a proteasome inhibitor (PI) and an immunomodulatory drug (IMID) ranged from 15 to 69% in young patients [10,11,13,14,16,17]. Autologous stem cell transplant (ASCT), currently considered a standard of care in young patients, was performed heterogeneously. Allogeneic SCT was seldom used. Median OS, reported in 4 studies, ranged from 61 to 175 months [10,13,16,17]. In studies with a comparator, all studies reported a longer 5-year OS in young patients [14,19,21].

4. Discussion

Whether MM of the young is a different disease entity remains unclear and a matter of debate. Different thresholds used to define disease characteristics at diagnosis such as creatinine, albumin, LDH, calcium level, number of lytic bone lesions, and cytogenetic abnormalities make comparisons between cohorts challenging. Nevertheless, it seems that young patients with MM tend to have less advanced disease (ISS 1) and present more frequently with the light chain subtype.
This review gathered the most recent studies available. However, only the older ISS classification was used. Now that cytogenetics are widely available, it would be important to focus on the revised-ISS (R-ISS) in young patients, which combines high LDH and B2-microglobulin, low albumin, and the presence of high-risk cytogenetic abnormalities including del (17p), t(4;14), and t(14;16) [29].
Cytogenetic risk stratification in MM is a powerful outcome predictor [30]. Primary genetic events, present in almost all myeloma cells at diagnosis, are divided into hyperdiploid and non-hyperdiploid rearrangements. Hyperdiploidy is characterized by trisomies of odd-numbered chromosomes (except for 1, 13, and 21) and it is usually associated with a more indolent disease course. The non-hyperdiploid changes involve translocations of the immunoglobulin heavy-chain (IGH) gene locus on chromosome 14 with several different partner genes, usually leading to poorer prognosis, although there is heterogeneity depending on the translocation partner gene [31] Secondary chromosomal aberrations, typically occurring in subclones, develop as the disease progresses. Copy number abnormalities and gene mutations such as deletion of TP53 represent secondary changes leading to a more aggressive disease course [32,33]. MM is therefore a multistep process starting from MGUS, to smoldering myeloma, then evolving into MM as genetic events accumulate. The specific chromosomal aberrations in young patients are crucial since they can reflect tumor evolution and response to certain therapies. Interphase fluorescence in situ hybridization (iFISH) is the technique of choice for cytogenetic analysis. Besides del (17p) deletion, t(4;14), and t(14;16), young patients should also be screened for other cytogenetic abnormalities associated with high-risk disease, such as t(14;20) and chromosome 1 abnormalities [29,32].
At the present time, it remains unclear whether young myeloma patients are more prone to have high-risk cytogenetics for several reasons. First, the number of patients included was limited. The techniques differed from one cohort to the other, while older studies resorted to conventional cytogenetics and more contemporary studies used iFISH. Importantly, the details of methods used were not universally reported, including plasma cell purification and iFISH positivity cut-offs. Finally, the MM panels used in each study were usually not described and the presence or absence of multiple cytogenetic abnormalities (double or triple hit defining a very high-risk group) was often not clearly specified [34,35,36]. Further modern, large-scale studies are necessary to understand the genetic landscape of young patients with MM. More advanced techniques such as next-generation sequencing (NGS) should also aid in our understanding.
Myeloma survival has improved in the past decade [37]. In young patients eligible for transplantation, a combination of a PI, an IMID, and dexamethasone, such as the bortezomib, lenalidomide, and dexamethasone (VRd) triplet should be used [38,39,40,41]. Quadruplet therapy, with the addition of daratumumab (D), a monoclonal antibody targeting CD38, has shown promising results in different clinical trials [42,43,44] and is currently used by some centers in patients with high-risk MM [45]. For transplant ineligible patients, initial treatments with combinations of VRd and DRd followed by maintenance are standards of care [46,47].
The outcome of young MM patients is difficult to predict for several reasons. Only a small subset has received contemporary regimens, emphasizing the urgent need for modern studies. ASCT was also heterogeneously used, possibly due to resource limitations in some centers. It is therefore impossible to show prognosis differences between patients who have received ASCT and those who have not. Allogeneic SCT was a rare occurrence. Considering that it is the only potential curative treatment approach with improved nonrelapse mortality over time, it could be an interesting strategy for these patients [48,49]. Long-term survival data are lacking in most studies, which is of paramount importance in young patients at risk of developing long-term complications such as secondary malignancies or infections due to prolonged immunosuppression. The role of minimal residual disease, which could be a better predictor of longer PFS and potentially OS, remains unclear in young patients [50,51].
The OS of younger patients has been shown to be longer in most studies, possibly due to a higher incidence of ISS 1, better tolerance to more intensive therapies, less frequent preexistent comorbidities, and reporting bias. Nevertheless, young patients have a near 70-fold increase in mortality compared to the general population [16]. Other studies did not find differences in survival, possibly due to different induction treatments, less frequent use of first line transplants, or higher prevalence of patients with high-risk cytogenetics [10,20].

5. Conclusions and Future Directions

There is evidence that young patients with MM tend to have less advanced disease (ISS 1), more frequent light chain subtype, and survive longer compared to their older counterparts. It remains unclear whether their disease characteristics at presentation are distinct, due to unknown R-ISS distribution, incomplete cytogenetic comparisons with older patients, and limited information on the impact of current standard treatments. This review emphasizes the need to perform contemporary, large-scale retrospective studies to improve knowledge regarding their presentation and outcomes in the era of modern treatments. Young patients should be enrolled in clinical trials and specific stratification of different age groups should be conducted to further understand the characteristics and outcomes of their disease. These patients are diagnosed during their most productive years of life and suffer from significantly higher personal, familial, professional, and economic burdens compared to older patients, urging the need for tailored treatment approaches. Survivorship of young patients with MM deserves particular attention given their long disease journey with multiple potential complications, including secondary malignancies. Further studies will elucidate if innovative cellular therapies such as upfront CAR-T cells or other novel cellular therapies could be beneficial in this population.

Author Contributions

Conceptualization: C.D., M.T., R.L., I.A. and J.R. Methodology: C.D., M.T., I.A. and J.R. Validation: J.-S.C. Writing—original draft preparation: M.T. and J.R. Writing—review and editing: C.D., M.T., R.L., I.A., J.-S.C. and J.R. Supervision: J.R. Funding acquisition: J.R. All authors have read and agreed to the published version of the manuscript.

Funding

This work was supported by the Maryse and William Brock Chair in applied research into stem cell transplantation at Université de Montréal (J.R. recipient).

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Blimark, C.H.; Turesson, I.; Genell, A.; Ahlberg, L.; Björkstrand, B.; Carlson, K.; Forsberg, K.; Juliusson, G.; Linder, O.; Mellqvist, U.-H.; et al. Outcome and survival of myeloma patients diagnosed 2008–2015. Real-world data on 4904 patients from the Swedish Myeloma Registry. Haematologica 2018, 103, 506–513. [Google Scholar] [CrossRef] [PubMed]
  2. National Cancer Institute. SEER Cancer Statistics Factsheets: Multiple Myeloma. Available online: https://seer.cancer.gov/statfacts/html/mulmy.html (accessed on 3 January 2023).
  3. Kyle, R.A.; Gertz, M.A.; Witzig, T.E.; Lust, J.A.; Lacy, M.Q.; Dispenzieri, A.; Fonseca, R.; Rajkumar, S.V.; Offord, J.R.; Larson, D.R.; et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin. Proc. 2003, 78, 21–33. [Google Scholar] [CrossRef] [PubMed]
  4. Ludwig, H.; Bolejack, V.; Crowley, J.; Bladé, J.; Miguel, J.S.; Kyle, R.A.; Rajkumar, S.V.; Shimizu, K.; Turesson, I.; Westin, J.; et al. Survival and Years of Life Lost in Different Age Cohorts of Patients with Multiple Myeloma. J. Clin. Oncol. 2010, 28, 1599–1605. [Google Scholar] [CrossRef] [PubMed]
  5. Van der Poel, M.W.M.; Oerlemans, S.; Schouten, H.C.; van de Poll-Franse, L.V. Elderly multiple myeloma patients experience less deterioration in health-related quality of life than younger patients compared to a normative population: A study from the population-based PROFILES registry. Ann. Hematol. 2015, 94, 651–661. [Google Scholar] [CrossRef]
  6. Lenhoff, S.; Hjorth, M.; Westin, J.; Brinch, L.; Bäckström, B.; Carlson, K.; Christiansen, I.; Dahl, I.M.; Gimsing, P.; Hammerström, J.; et al. Impact of age on survival after intensive therapy for multiple myeloma: A population-based study by the Nordic Myeloma Study Group. Br. J. Haematol. 2006, 133, 389–396. [Google Scholar] [CrossRef]
  7. Bladé, J.; Kyle, R.A.; Greipp, P.R. Presenting features and prognosis in 72 patients with multiple myeloma who were younger than 40 years. Br. J. Haematol. 1996, 93, 345–351. [Google Scholar] [CrossRef]
  8. Corso, A.; Klersy, C.; Lazzarino, M.; Bernasconi, C. Multiple myeloma in younger patients: The role of age as prognostic factor. Ann. Hematol. 1998, 76, 67–72. [Google Scholar] [CrossRef]
  9. Ludwig, H.; Durie, B.G.; Bolejack, V.; Turesson, I.; Kyle, R.A.; Blade, J.; Fonseca, R.; Dimopoulos, M.; Shimizu, K.; San Miguel, J.; et al. Myeloma in patients younger than age 50 years presents with more favorable features and shows better survival: An analysis of 10 549 patients from the International Myeloma Working Group. Blood 2008, 111, 4039–4047. [Google Scholar] [CrossRef]
  10. Shin, J.; Koh, Y.; Youk, J.; Kim, M.; Kim, B.S.; Choi, C.W.; Sung, H.J.; Park, Y.; Yoon, S.S.; Kim, I. Clinicopathological characteristics of extremely young Korean multiple myeloma patients: Therapeutic implications. Korean J. Intern. Med. 2017, 32, 722–730. [Google Scholar] [CrossRef]
  11. Ravi, P.; Kumar, S.K.; Cerhan, J.R.; Maurer, M.J.; Dingli, D.; Ansell, S.M.; Rajkumar, S.V. Defining cure in multiple myeloma: A comparative study of outcomes of young individuals with myeloma and curable hematologic malignancies. Blood Cancer J. 2018, 8, 26. [Google Scholar] [CrossRef]
  12. Yanamandra, U.; Saini, N.; Chauhan, P.; Sharma, T.; Khadwal, A.; Prakash, G.; Varma, N.; Lad, D.; Varma, S.; Malhotra, P. AYA-Myeloma: Real-World, Single-Center Experience Over Last 5 Years. J. Adolesc. Young Adult Oncol. 2018, 7, 120–124. [Google Scholar] [CrossRef]
  13. Jurczyszyn, A.; Davila, J.; Kortüm, K.M.; Jayabalan, D.S.; Vij, R.; Fiala, M.; Milunovic, V.; Chim, C.S.; Wiśniewska-Piąty, K.; Waszczuk-Gajda, A.; et al. Multiple myeloma in patients up to 30 years of age: A multicenter retrospective study of 52 cases. Leuk. Lymphoma 2019, 60, 471–476. [Google Scholar] [CrossRef]
  14. Pál, I.; Illés, Á.; Váróczy, L. Multiple Myeloma of the Young—A Single Center Experience Highlights Future Directions. Pathol. Oncol. Res. 2020, 26, 419–424. [Google Scholar] [CrossRef]
  15. Duek, A.; Trakhtenbrot, L.; Avigdor, A.; Nagler, A.; Leiba, M. Multiple Myeloma Presenting in Patients Younger than 50 Years of Age: A Single Institution Experience. Acta Haematol. 2021, 144, 58–65. [Google Scholar] [CrossRef]
  16. Caulier, A.; Roussel, M.; Morel, P.; Lombion, N.; Branco, B.; Galtier, J.; Hulin, C.; Perrot, A.; Richez, V.; Michaud-Robert, A.V.; et al. Epidemiological landscape of young multiple myeloma patients diagnosed earlier than 40 years: The french experience. Blood 2021, 138, 2686–2695. [Google Scholar] [CrossRef]
  17. Bao, A.; Zhao, Q.; Merritt, E.; Bumma, N.; Devarakonda, S.; Khan, A.M.; Umyarova, E.; Rosko, A.E.; Benson, D.M.; Cottini, F. Racial differences as predictors of outcomes in young patients with multiple myeloma. Blood Cancer J. 2022, 12, 114. [Google Scholar] [CrossRef]
  18. Lu, J.; Lu, J.; Chen, W.; Wang, J.; Huo, Y.; Hou, J.; Huang, X. More frequent IgD and reduced CD200 expression in Chinese patients younger than 50 years old with multiple myeloma: A multicenter analysis. Drug Des. Dev. 2016, 10, 3673–3679. [Google Scholar] [CrossRef]
  19. Jurczyszyn, A.; Nahi, H.; Avivi, I.; Gozzetti, A.; Niesvizky, R.; Yadlapati, S.; Jayabalan, D.S.; Robak, P.; Pika, T.; Andersen, K.T.; et al. Characteristics and outcomes of patients with multiple myeloma aged 21–40 years versus 41–60 years: A multi-institutional case-control study. Br. J. Haematol. 2016, 175, 884–891. [Google Scholar] [CrossRef]
  20. Dhakal, B.; Nelson, A.; Murthy, G.S.G.; Fraser, R.; Eastwood, D.; Hamadani, M.; Pasquini, M.; D’Souza, A.; Hari, P. Autologous Hematopoietic Cell Transplantation in Patients with Multiple Myeloma: Effect of Age. Clin. Lymphoma Myeloma Leuk. 2017, 17, 165–172. [Google Scholar] [CrossRef]
  21. Nakaya, A.; Kohara, T.; Shibayama, H.; Onda, Y.; Kanda, J.; Kaneko, H.; Imada, K.; Kida, T.; Kosugi, S.; Ishikawa, J.; et al. Retrospective multi-center study of Adolescent and Young Adult (AYA) Multiple Myeloma in Kansai Myeloma Forum registry. Int. J. Hematol. 2020, 112, 435–438. [Google Scholar] [CrossRef]
  22. Pydi, V.R.; Bala, S.C.; Kuruva, S.P.; Chennamaneni, R.; Konatam, M.L.; Gundeti, S. Multiple Myeloma in Young Adults: A Single Centre Real World Experience. Indian J. Hematol. Blood Transfus. Off. J. Indian Soc. Hematol. Blood Transfus. 2021, 37, 679–683. [Google Scholar] [CrossRef]
  23. Rafae, A.; Malik, M.N.; Abu Zar, M.; Durer, S.; Durer, C. An Overview of Light Chain Multiple Myeloma: Clinical Characteristics and Rarities, Management Strategies, and Disease Monitoring. Cureus 2018, 10, e3148. [Google Scholar] [CrossRef] [PubMed]
  24. Kastritis, E.; Terpos, E.; Roussou, M.; Gavriatopoulou, M.; Migkou, M.; Eleutherakis-Papaiakovou, E.; Fotiou, D.; Ziogas, D.; Panagiotidis, I.; Kafantari, E.; et al. Evaluation of the Revised International Staging System in an independent cohort of unselected patients with multiple myeloma. Haematologica 2017, 102, 593–599. [Google Scholar] [CrossRef] [PubMed]
  25. Altieri, A.; Chen, B.; Bermejo, J.L.; Castro, F.; Hemminki, K. Familial risks and temporal incidence trends of multiple myeloma. Eur. J. Cancer 2006, 42, 1661–1670. [Google Scholar] [CrossRef] [PubMed]
  26. Vachon, C.M.; Kyle, R.A.; Therneau, T.M.; Foreman, B.J.; Larson, D.R.; Colby, C.L.; Phelps, T.K.; Dispenzieri, A.; Kumar, S.K.; Katzmann, J.A.; et al. Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance. Blood 2009, 114, 785–790. [Google Scholar] [CrossRef]
  27. Clay-Gilmour, A.I.; Kumar, S.; Rajkumar, S.V.; Rishi, A.; Kyle, R.A.; Katzmann, J.A.; Murray, D.L.; Norman, A.D.; Greenberg, A.J.; Larson, D.R.; et al. Risk of MGUS in relatives of multiple myeloma cases by clinical and tumor characteristics. Leukemia 2019, 33, 499–507. [Google Scholar] [CrossRef]
  28. Walker, B.A.; Wardell, C.P.; Murison, A.; Boyle, E.M.; Begum, D.B.; Dahir, N.M.; Proszek, P.Z.; Melchor, L.; Pawlyn, C.; Kaiser, M.F.; et al. APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma. Nat. Commun. 2015, 6, 6997. [Google Scholar] [CrossRef]
  29. Palumbo, A.; Avet-Loiseau, H.; Oliva, S.; Lokhorst, H.M.; Goldschmidt, H.; Rosinol, L.; Richardson, P.; Caltagirone, S.; Lahuerta, J.J.; Facon, T.; et al. Revised International Staging System for Multiple Myeloma: A Report From International Myeloma Working Group. J. Clin. Oncol. 2015, 33, 2863–2869. [Google Scholar] [CrossRef]
  30. Fonseca, R.; Blood, E.; Rue, M.; Harrington, D.; Oken, M.M.; Kyle, R.A.; Dewald, G.W.; Van Ness, B.; Van Wier, S.A.; Henderson, K.J.; et al. Clinical and biologic implications of recurrent genomic aberrations in myeloma. Blood 2003, 101, 4569–4575. [Google Scholar] [CrossRef]
  31. Fonseca, R.; Debes-Marun, C.S.; Picken, E.B.; Dewald, G.W.; Bryant, S.C.; Winkler, J.M.; Blood, E.; Oken, M.M.; Santana-Dávila, R.; González-Paz, N.; et al. The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma. Blood 2003, 102, 2562–2567. [Google Scholar] [CrossRef]
  32. Rajkumar, S.V. Multiple myeloma: 2020 update on diagnosis, risk-stratification and management. Am. J. Hematol. 2020, 95, 548–567. [Google Scholar] [CrossRef]
  33. Manier, S.; Salem, K.Z.; Park, J.; Landau, D.A.; Getz, G.; Ghobrial, I.M. Genomic complexity of multiple myeloma and its clinical implications. Nat. Rev. Clin. Oncol. 2017, 14, 100–113. [Google Scholar] [CrossRef]
  34. Singh, C.; Panakkal, V.; Sreedharanunni, S.; Jandial, A.; Jain, A.; Lad, D.; Prakash, G.; Khadwal, A.; Malhotra, P. Presentation and Impact of Double and Triple hit Cytogenetics in Patients With Multiple Myeloma in the Real World. Clin. Lymphoma Myeloma Leuk. 2022, 22, e685–e690. [Google Scholar] [CrossRef] [PubMed]
  35. Marcon, C.; Simeon, V.; Deias, P.; Facchin, G.; Corso, A.; Derudas, D.; Montefusco, V.; Offidani, M.; Petrucci, M.T.; Zambello, R.; et al. Experts’ consensus on the definition and management of high risk multiple myeloma. Front. Oncol. 2022, 12, 1096852. [Google Scholar] [CrossRef]
  36. Walker, B.A.; Mavrommatis, K.; Wardell, C.P.; Ashby, T.C.; Bauer, M.; Davies, F.; Rosenthal, A.; Wang, H.; Qu, P.; Hoering, A.; et al. A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis. Leukemia 2019, 33, 159–170. [Google Scholar] [CrossRef]
  37. Langseth, Ø.O.; Myklebust, T.; Johannesen, T.B.; Hjertner, Ø.; Waage, A. Incidence and survival of multiple myeloma: A population-based study of 10 524 patients diagnosed 1982–2017. Br. J. Haematol. 2020, 191, 418–425. [Google Scholar] [CrossRef]
  38. Attal, M.; Lauwers-Cances, V.; Hulin, C.; Leleu, X.; Caillot, D.; Escoffre, M.; Arnulf, B.; Macro, M.; Belhadj, K.; Garderet, L.; et al. Lenalidomide, Bortezomib, and Dexamethasone with Transplantation for Myeloma. N. Engl. J. Med. 2017, 376, 1311–1320. [Google Scholar] [CrossRef]
  39. Rosiñol, L.; Oriol, A.; Rios, R.; Sureda, A.; Blanchard, M.J.; Hernández, M.T.; Martínez-Martínez, R.; Moraleda, J.M.; Jarque, I.; Bargay, J.; et al. Bortezomib, lenalidomide, and dexamethasone as induction therapy prior to autologous transplant in multiple myeloma. Blood 2019, 134, 1337–1345. [Google Scholar] [CrossRef]
  40. Roussel, M.; Lauwers-Cances, V.; Robillard, N.; Hulin, C.; Leleu, X.; Benboubker, L.; Marit, G.; Moreau, P.; Pegourie, B.; Caillot, D.; et al. Front-Line Transplantation Program With Lenalidomide, Bortezomib, and Dexamethasone Combination As Induction and Consolidation Followed by Lenalidomide Maintenance in Patients With Multiple Myeloma: A Phase II Study by the Intergroupe Francophone du Myélome. J. Clin. Oncol. 2014, 32, 2712–2717. [Google Scholar] [CrossRef]
  41. Richardson, P.G.; Weller, E.; Lonial, S.; Jakubowiak, A.J.; Jagannath, S.; Raje, N.S.; Avigan, D.E.; Xie, W.; Ghobrial, I.M.; Schlossman, R.L.; et al. Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood 2010, 116, 679–686. [Google Scholar] [CrossRef]
  42. Moreau, P.; Attal, M.; Hulin, C.; Arnulf, B.; Belhadj, K.; Benboubker, L.; Béné, M.C.; Broijl, A.; Caillon, H.; Caillot, D.; et al. Bortezomib, thalidomide, and dexamethasone with or without daratumumab before and after autologous stem-cell transplantation for newly diagnosed multiple myeloma (CASSIOPEIA): A randomised, open-label, phase 3 study. Lancet 2019, 394, 29–38. [Google Scholar] [CrossRef] [PubMed]
  43. Voorhees, P.M.; Kaufman, J.L.; Laubach, J.P.; Sborov, D.W.; Reeves, B.; Rodriguez, C.; Chari, A.; Silbermann, R.W.; Costa, L.J.; Anderson, L.D.; et al. Depth of Response to Daratumumab (DARA), Lenalidomide, Bortezomib, and Dexamethasone (RVd) Improves over Time in Patients (pts) with Transplant-Eligible Newly Diagnosed Multiple Myeloma (NDMM): Griffin Study Update. Blood 2019, 134, 691. [Google Scholar] [CrossRef]
  44. Landgren, O.; Hultcrantz, M.; Diamond, B.; Lesokhin, A.M.; Mailankody, S.; Hassoun, H.; Tan, C.; Shah, U.A.; Lu, S.X.; Salcedo, M.; et al. Safety and Effectiveness of Weekly Carfilzomib, Lenalidomide, Dexamethasone, and Daratumumab Combination Therapy for Patients With Newly Diagnosed Multiple Myeloma: The MANHATTAN Nonrandomized Clinical Trial. JAMA Oncol. 2021, 7, 862–868. [Google Scholar] [CrossRef]
  45. Rajkumar, S.V. Multiple myeloma: 2022 update on diagnosis, risk stratification, and management. Am. J. Hematol. 2022, 97, 1086–1107. [Google Scholar] [CrossRef] [PubMed]
  46. Durie, B.G.M.; Hoering, A.; Abidi, M.H.; Rajkumar, S.V.; Epstein, J.; Kahanic, S.P.; Thakuri, M.; Reu, F.; Reynolds, C.M.; Sexton, R.; et al. Bortezomib with lenalidomide and dexamethasone versus lenalidomide and dexamethasone alone in patients with newly diagnosed myeloma without intent for immediate autologous stem-cell transplant (SWOG S0777): A randomised, open-label, phase 3 trial. Lancet 2017, 389, 519–527. [Google Scholar] [CrossRef]
  47. Facon, T.; Kumar, S.; Plesner, T.; Orlowski, R.Z.; Moreau, P.; Bahlis, N.; Basu, S.; Nahi, H.; Hulin, C.; Quach, H.; et al. Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma. N. Engl. J. Med. 2019, 380, 2104–2115. [Google Scholar] [CrossRef]
  48. Claveau, J.-S.; Buadi, F.K.; Kumar, S. Current Role of Allogeneic Stem Cell Transplantation in Multiple Myeloma. Oncol. Ther. 2022, 10, 105–122. [Google Scholar] [CrossRef]
  49. LeBlanc, R.; Ahmad, I.; Terra, R.; Boudreault, J.-S.; Ogez, D.; Lamore, K.; Delisle, J.-S.; Bambace, N.; Bernard, L.; Cohen, S.; et al. Outcomes in newly diagnosed young or high-risk myeloma patients receiving tandem autologous/allogeneic transplant followed by bortezomib maintenance: A phase II study. Bone Marrow Transplant. 2022, 57, 252–260. [Google Scholar] [CrossRef]
  50. Munshi, N.C.; Avet-Loiseau, H.; Anderson, K.C.; Neri, P.; Paiva, B.; Samur, M.; Dimopoulos, M.; Kulakova, M.; Lam, A.; Hashim, M.; et al. A large meta-analysis establishes the role of MRD negativity in long-term survival outcomes in patients with multiple myeloma. Blood Adv. 2020, 4, 5988–5999. [Google Scholar] [CrossRef]
  51. Goicoechea, I.; Puig, N.; Cedena, M.-T.; Burgos, L.; Cordón, L.; Vidriales, M.-B.; Flores-Montero, J.; Gutierrez, N.C.; Calasanz, M.-J.; Ramos, M.-L.M.; et al. Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard- and high-risk myeloma. Blood 2021, 137, 49–60. [Google Scholar] [CrossRef]
Curroncol 30 00396 g001 550
Figure 1. Consort diagram.
Figure 1. Consort diagram.
Curroncol 30 00396 g001
Curroncol 30 00396 g002 550
Figure 2. PubMed search strategy. * Truncation to find variations of a word.
Figure 2. PubMed search strategy. * Truncation to find variations of a word.
Curroncol 30 00396 g002
Table
Table 1. Patients’ characteristics at diagnosis included in studies without a comparator.
Table 1. Patients’ characteristics at diagnosis included in studies without a comparator.
Bladé
1996 [7]		Shin
2017 [10]		Ravi
2018 [11]		Yanamandra
2018 [12]		Jurczyszyn
2019 [13]		Pál
2020 [14]		Duek
2021 [15]		Caulier
2021 [16]		Bao
2022 [17]
n723221240521623214258
CountryUSASouth KoreaUSAIndiaEurope, USA, Brazil, Hong KongHungaryIsraelFrance, BelgiumUSA
Years of diagnosis1956–19922000–20152005–20152010–20151989–20162006–20152009–20142000–20151992–2019
Patients’ age (years)<40≤40≤50<40≤30≤40<50≤40<50
Median age (range)36 (19–39)37 (17–40)45 (22–49)38 (18–39)28 (8–30)39 (31–40)41.5 (27–49)37.2 (18.6–40.9)46 (17–50)
Male/female50/2219/13129/8326/1435/1710/617/6137/77165/93
ISS
INA10/31 (32)74/212 (35) b5/40 (13)32/47 (68)7/16 (44)5/14 (36)99/189 (52)89/212 (42)
IINA15/31 (48)46/212 (22) b7/40 (18)7/47 (15)5/16 (31)6/14 (43)52/189 (28)66/212 (31)
IIINA6/31 (19)48/212 (23) b28/40 (70)8/47 (17)4/16 (25)3/14 (21)38/189 (20)57/212 (27)
Disease features at diagnosis
Anemia (<100 g/L)NA9/31 (29)NA21/40 (53)13/43 (30)2/16 (13)6/18 (33)71/202 (35)NA
Kidney disease a15/52 (29)4/32 (13)NA12/40 (30)4/22 (18)2/16 (13)3/18 (17)34/200 (17)NA
Low albumin a 8/49 (16)9/32 (28)NANA11/41 (27)NA8/18 (44)NANA
Hypercalcemia a16/53 (30)9/32 (28)NA9/37 (24)6/42 (14)3/16 (19)1/18 (6)25/195 (13)NA
Lytic bone lesions44/65 (68)27/31 (87)NA16/37 (59)36/44 (82)14/16 (88)16/18 (89)149/200 (75)NA
Elevated ß2MG a18/33 (55)14/29 (48)NANA11/41 (27)NANANANA
Protein isotype
Heavy chain NA
IgG34/66 (51)14/30 (47)NA(76)27/49 (55)8/16 (50)11/22 (50)130/162 (80)121/258 (47)
IgA 7/66 (11)5/30 (17)NA(11)9/49 (18)3/16 (19)2/22 (9)28/162 (17)53/258 (21)
IgD 4/66 (6)2/30 (7)NANANA0/16 (0)NA3/162 (2)NA
IgMNANANA(3)NA0/16 (0)NA1/162 (0.6)NA
Light chain only21/66 (32)9/30 (30)NA(11)11/49 (22)3/16 (19)10/22 (45) c51/213 (24)72/258 (28)
a Variable cut-off; b Numbers not adding to 100% due to missing data; c One case with isotypes IgG kappa and free lambda; Abbreviations: ß2MG: Beta-2 microglobulin; ISS: International Staging System; NA: not available. Numbers in parentheses represent percentages.
Table
Table 2. Patients’ characteristics at diagnosis included in studies with a comparator.
Table 2. Patients’ characteristics at diagnosis included in studies with a comparator.
Corso 1998 [8]Ludwig 2008 [9]Lu 2016 [18]Jurczyszyn 2016 [19]Dhakal 2017 [20]Nakaya 2020 [21]Pydi 2021 [22]
n35610,54994010891912303280
CountryItalyNorth America, Europe, JapanChinaEurope, USAUSAJapanIndia
Years of diagnosis1973–19941981–20022008–20112000–20152000 to 20151998–20182013–2018
Age studied (years)<50≥50<50≥50<50≥5021–4041–60≤50>70<40All≤40All patients
n (by age group)61295168988601947461739168610526227722258
Median age (range)45 (33–49)63 (50–87)36 (20–49)62 (50–93)46 (20–49)62 (50–88)37 (21–40)55 (41–60)46 (32–50)73 (71–79)36 (20–39)74 (20–96)33.5 (18–40)56 (18–84)
Male/female32/29169/1261023/6665014/3846113/81457/289104/69510/40670/1658/4713/131116/116114:8NA
ISS
INANA492/1267 (39)1790/6776 (26) p < 0.001(30)(17)
p < 0.001		71/151 (47)303/729 (42)
p = 0.40		15/86 (17) d29/105 (27)
p = 0.31 d		(43)(23)
p = 0.019		(18)(17)
IINANA438/1267 (35)2675/6776 (39)
p < 0.001		(31)(32)
p = 0.774		50/151 (33)280/729 (38)22/86 (26) d22/105 (21) d(38)(40)
p = 0.910		(32)(33)
IIINANA337/1267 (27)2311/6776 (34)
p < 0.001		(39)(51)
p 0.007		30/151 (20)149/729 (20)20/86 (23) d28/105 (27) d(19)(37)
p = 0.022		(50)(50)
Disease features at diagnosis
Anemia (<100 g/L)NANA596/1614 (37)3465/8539 (41)
p = 0.006		(56)(61)
p = 0.265		53/173 (31)247/925 (27)
p = 0.29		NANA6/26 (23)NA(68)(63)
Kidney disease a5/61 (8)41/295 (14)240/1594 (15)1484/8573 (17)
p = 0.028		(21)(25)
p = 0.300		40/160 (25)265/855 (31)
p = 0.13		NANA11/26 (42)NA(50)(36)
Low albumin aNANA458/1396 (33)3276/7912 (41)
p < 0.001		(37)(58)
p < 0.001		NANANANANANANANA
Hypercalcemia a4/61 (6)17/295 (6)481/1445 (33)2652/7870 (34)
p = 0.762		NANA26/160 (16)86/668 (13)
p = 0.26		NANA1/26 (4)NA(9)(26)
Lytic bone lesions26/61 (43) b100/295 (34) b617/1292 (48) c3457/7423 (47) c
p = 0.431		82/109 (75) c334/403 (83)
p = 0.569 c		139/170 (82)644/868
(74)
p = 0.04		NANA18/26 (69)NA(59)(76)
Elevated ß2MG aNANA613/1377 (45)4141/7061 (59)
p < 0.001		(46)(62)
p < 0.001		NANANANANANANANA
Protein isotype
Heavy chain
IgG40/61 (65)197/295 (67)924/1538 (60)4853/8091 (60)
p = 0.943		75/194 (39)341/746 (46)
p = 0.078		107/156 (69)375/632 (59)
p = 0.10		34/86 (40)56/105 (53)
p = 0.06		(45)(58)
p = 0.237		(50)(55)
IgA11/61 (18)59/295 (20)318/1538 (21)2009/8091 (25)
p < 0.001		28/194 (14)141/746 (19)
p = 0.149		26/156 (17)127/632 (20)9/86 (10)21/105 (20)(11)(22)
p = 0.080		(5)(12)
IgD1/61 (1)3/295 (1)43/1538 (3)251/8091 (3)
p = 0.522		20/194 (10)41/746 (5.5)
p = 0.015		1/156 (0.6)16/632 (3)NANA(4)(1)
p = 0.375		NANA
IgMNANANANANANANANANANANANANANA
Light chain only8/61 (12)26/295 (8)197/1538 (13)824/8091 (10)
p = 0.002		64/194 (33)195/746 (26)
p = 0.057		NANA26/86 (30)19/105 (18)(33)(16)
p = 0.021		(41)(33)
a Variable cut-offs; b Extensive lytic lesions; c more than 3 bone lesions; d numbers not adding to 100% due to missing data; Abbreviations: ß2MG: Beta-2 microglobulin; ISS: International Staging System; NA: not available. Numbers in parentheses represent percentages.
Table
Table 3. Cytogenetics at diagnosis.
Table 3. Cytogenetics at diagnosis.
Studies without a ComparatorStudies with a Comparator
Shin
2017 [10]		Jurczyszyn
2019 [13]		Pál
2020
[14,15]		Duek
2021
[15] 		Caulier
2021 [16]		Pydi
2021 [22]		Bao
2022 [17] h		Ludwig
2008 [9]		Jurczyszyn
2016 [19]		Lu
2016 [18]		Nakaya
2020 [21]
Age studied
(years)		≤40≤30≤40<50≤40≤40<50<50≥5021–4041–60<50≥50<40 yearsAll patients
Median 74
HyperdiploidNANA6/11 (55)1/22
(4.5)		NANANANANANANA3/33 (9)8/120 (7)NANA
Non-hyperdiploidNA19/21 (90)NANANANAHypodiploid
5/210 (2)		NANANANA4/33 (12)24/120 (20)NANA
t(11;14)NA1/20 (5)NA15/22 (68) a,b9/35 (26)2/7 (29)42/210 (20)NANANANANANA1/5 (20)83/316 (26)
p = 0.461
t(14;16)0/11 (0)NANA0/22 (0)1/39 (2.5)1/7 (14)NANANANANANANA0/7 (0)27/532 (5)
p = 0.063
t(14;20)0/6 (0)NANA0/22 (0)NANANANANANANANANANANA
t(8;14)NANANANANANA4/210 (2)NANANANANANANANA
t(4;14)1/10 (10)0/20 (0)3/11 (27)0/22 (0)19/156 (12) e1/7 (14)15/210 (7)NANA26/81 (32) j31/181 (17) j
p = 0.007		NANA2/8 (25)168/802 (21)
p = 0.659
del (17p)/17
delp53		1/9 (11)2/21 (10)2/11 (18)1/22 (4.5)17/141 (12) e1/7 (14)15/210 (7)NANA17/91 (19) i61/351 (17)
p 0.771 i		3/9 (33)86/606 (14)
p = 0.008
+ or amp 1q21/1q gain4/15 (27)2/17 (12)NANA17/56 (30) fNA48/210 (23)NANANANA49/87 (56) i139/313
(44)
p = 0.064 i		NANA
del (1p32)NANANA1/22 (4.5) c8/46 (17) gNANANANANANANANANANA
del (13q)/
del 13		4/17 (24)8/26 (31)NA9/22 (40) dNA3/7 (43)72/210 (34)32/53 (60) i150/320 (47)
p = 0.069 i		NANA13/37 (35) i 58/141 (41)
p = 0.507 i		4/8 (50)211/435 (49)
p = 1.000
17/109 (16) ii45/345 (13)
p = 0.499 ii		3/33 (9) ii9/120 (8)
p = 0.767 ii
del (9)1/16 (6)NANANANANANANANANANANANANANA
NA: not available. a sole aberration in 32%; b 3 also had IgH rearrangement, 6 also had del 13q, 1 also had delp53; c 1 also IgH rearranged; d 1 also had delp53, 6 also t(11;14), 3 also IgH rearranged, 1 also del 16q; e 2 patients had t(4;14) and del (17p); f Associated with high-risk cytogenetics in 5 patients; g Associated with high-risk cytogenetics in 2 patients and associated with +1q in 5 patients; h 7% had ≥2 high-risk chromosomal abnormalities; i by FISH; ii by conventional cytogenetics; j del (17p) and t(4;14) merged. Numbers in parentheses represent percentages.
Table
Table 4. Treatments and outcomes.
Table 4. Treatments and outcomes.
Studies without a ComparatorStudies with a Comparator
Shin
2017 [10]		Ravi
2018 [11]		Jurczyszyn
2019 [13]		Caulier
2021 [16]		Bao
2022 [17]		Jurczyszyn 2016 [19]Nakaya
2020 [21]		Pál
2020 [14]
n322125221425817391626227716296
Age studied (years)≤40≤50≤30≤40<5021–4041–60<40All≤40>40
Year of diagnosis2000–20152005–20152006–20162000–20151992–20192000–20151998–20182006–2015
Induction treatments (%) Novel agents, unspecified
PI based1045 b413022NANANANA6NA
IMID based3732 b24110NANANANA13NA
PI + IMIDs40 a15 b213727NANANANA69NA
Other (chemotherapy, melphalan, dexamethasone only)136 b152641NANANANA13NA
Radiotherapy onlyNANANA6NANANANANANANA
Transplant
ASCT (%) 1st line62NA62NANANANANANA88NA
ASCT (%)—at any stage7952NA9387118939NANANA
Allo-SCT (%)0NA3255 cNANA42 dNANANA
Survival data
Median follow-up (months)6469.6867693.65178NANA
Median OS (months)61NA166175112.8NANANANANANA
5-years OS (%)5470778486 (NHBP)
66 (NHWP)		8367
p < 0.001		71568353
Median PFS (months) 16NANA4138.4 (NHWP),
70.8 (NHPB)		NANANANANANA
5-years PFS (%)1428NANANANANANANA4835
a VAD +/− VTD; b numbers not adding to 100% due to missing data; c ASCT followed by Allo-SCT d 23% with a combination of ASCT and allo-SCT + 19% allo-SCT. ASCT: autologous stem cell transplant; Allo-SCT: allogeneic stem cell transplant; NHBP: non-hispanic black people; NHWP: non-hispanic white people; OS: overall survival; PFS: progression-free survival.
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Tanguay, M.; Dagenais, C.; LeBlanc, R.; Ahmad, I.; Claveau, J.-S.; Roy, J. Young Myeloma Patients: A Systematic Review of Manifestations and Outcomes. Curr. Oncol. 2023, 30, 5214-5226. https://doi.org/10.3390/curroncol30060396

AMA Style

Tanguay M, Dagenais C, LeBlanc R, Ahmad I, Claveau J-S, Roy J. Young Myeloma Patients: A Systematic Review of Manifestations and Outcomes. Current Oncology. 2023; 30(6):5214-5226. https://doi.org/10.3390/curroncol30060396

Chicago/Turabian Style

Tanguay, Mégane, Christophe Dagenais, Richard LeBlanc, Imran Ahmad, Jean-Sébastien Claveau, and Jean Roy. 2023. "Young Myeloma Patients: A Systematic Review of Manifestations and Outcomes" Current Oncology 30, no. 6: 5214-5226. https://doi.org/10.3390/curroncol30060396

APA Style

Tanguay, M., Dagenais, C., LeBlanc, R., Ahmad, I., Claveau, J. -S., & Roy, J. (2023). Young Myeloma Patients: A Systematic Review of Manifestations and Outcomes. Current Oncology, 30(6), 5214-5226. https://doi.org/10.3390/curroncol30060396

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