Quality of Life and Symptoms of Hospitalized Hematological Cancer Patients
Abstract
:1. Introduction
2. Materials and Methods
2.1. Setting and Sample
2.2. Instrumentation
2.3. Statistical Analysis
2.4. Ethics
3. Results
3.1. Patients’ Characteristics
3.2. Descriptive Data of Variables
3.3. Correlations Between QOL and Patients’ Symptoms
3.4. Correlations Between QOL and Patients’ Characteristics
3.5. Correlations Between Symptoms and Patients’ Characteristics
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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N | % | ||
---|---|---|---|
Gender | men/women | 69/51 | 57.5/42.5 |
Age (years) | Mean age ± (min–max) | 65.6 ± 17.5 (18.7–94.3) | |
<60 | 41 | 34.2 | |
60–79 | 55 | 45.8 | |
80+ | 24 | 20.0 | |
Μarital Status | Unmarried/Divorced/Widowed | 38 | 31.7 |
Married, Cohabitation | 82 | 68.3 | |
Education | Primary school | 51 | 42.5 |
Middle school | 22 | 18.3 | |
High school | 23 | 19.2 | |
University | 24 | 20.0 | |
Living alone | Yes | 20 | 16.7 |
Νo | 100 | 83.3 | |
Employment | Unemployed/Retired/Housekeeping | 89 | 74.2 |
Employees | 25 | 20.8 | |
Freelancers/Farmers | 6 | 5.0 | |
Residence | Urban area | 86 | 71.7 |
Rural Area | 34 | 28.3 | |
Time from diagnosis (months) | Mean (median) (min–max) | 33 (48) (1–276) | |
Comorbidities | Νone | 44 | 36.7 |
1 | 40 | 33.3 | |
2+ | 36 | 30.0 |
EORTC QLQ C30 Subscales | Mean | SD * | Median | Range |
---|---|---|---|---|
Global health status/QoL | 47.1 | 21.5 | 50.0 | 0–100 |
Functional scales (Higher score shows better QoL) | ||||
Physical functioning | 58.1 | 25.5 | 60.0 | 0–100 |
Role functioning | 46.1 | 32.8 | 41.7 | 0–100 |
Emotional functioning | 64.7 | 27.3 | 75.0 | 0–100 |
Cognitive functioning | 72.8 | 28.2 | 83.3 | 0–100 |
Social functioning | 58.9 | 31.3 | 66.7 | 0–100 |
Symptom scales/items (Lower score shows better QoL) | ||||
Fatigue | 59.1 | 25.6 | 66.7 | 0–100 |
Nausea and vomiting | 11.0 | 21.4 | 0,0 | 0–100 |
Pain | 34.9 | 31.5 | 33.3 | 0–100 |
Dyspnea | 44.7 | 31.9 | 33.3 | 0–100 |
Insomnia | 35.8 | 34.1 | 33.3 | 0–100 |
Appetite loss | 33.3 | 34.6 | 33.3 | 0–100 |
Constipation | 23.6 | 32.5 | 0.0 | 0–100 |
Diarrhea | 15.6 | 28.6 | 0.0 | 0–100 |
Financial difficulties | 28.6 | 32.4 | 33.3 | 0–100 |
Symptom Items | Mean | SD * | Median | Min | Max | N | % | |
---|---|---|---|---|---|---|---|---|
Part I 1 | Fatigue | 3.5 | 3.2 | 2.0 | 0.0 | 10.0 | 94 | 78.3 |
Drowsiness | 3.3 | 3.4 | 2.0 | 0.0 | 10.0 | 78 | 65.0 | |
Distress | 2.8 | 3.1 | 1.0 | 0.0 | 10.0 | 79 | 65.8 | |
Dry mouth | 2.8 | 3.3 | 1.0 | 0.0 | 10.0 | 74 | 61.7 | |
Sadness | 2.8 | 3.2 | 2.0 | 0.0 | 10.0 | 72 | 60.0 | |
Disturbed Sleep | 2.5 | 3.0 | 1.0 | 0.0 | 10.0 | 72 | 60.0 | |
Anorexia | 2.2 | 3.0 | 1.0 | 0.0 | 10.0 | 62 | 51.7 | |
Numbness and Tingling | 2.1 | 3.1 | 0.0 | 0.0 | 10.0 | 52 | 43.3 | |
Pain | 1.9 | 2.8 | 0.5 | 0.0 | 10.0 | 60 | 50.0 | |
Constipation | 1.7 | 3.0 | 0.0 | 0.0 | 10.0 | 40 | 33.3 | |
Memory problems | 1.6 | 2.7 | 0.0 | 0.0 | 10.0 | 51 | 42.5 | |
Shortness of breath | 1.5 | 2.8 | 0.0 | 0.0 | 10.0 | 46 | 38.3 | |
Nausea | 1.2 | 2.4 | 0.0 | 0.0 | 10.0 | 40 | 33.3 | |
Diarrhea | 1.2 | 2.7 | 0.0 | 0.0 | 10.0 | 29 | 24.2 | |
Vomiting | 0.6 | 1.7 | 0.0 | 0.0 | 10.0 | 19 | 15.8 | |
Part II 2 | Enjoyment of life | 5.1 | 3.6 | 5.0 | 0.0 | 10.0 | 103 | 85.8 |
Walking | 4.7 | 3.5 | 4.0 | 0.0 | 10.0 | 99 | 82.5 | |
Mood | 4.4 | 3.4 | 4.0 | 0.0 | 10.0 | 99 | 82.5 | |
Work | 4.3 | 3.7 | 4.0 | 0.0 | 10.0 | 90 | 75.0 | |
General Activity | 4.2 | 3.4 | 4.0 | 0.0 | 10.0 | 96 | 80.0 | |
Relations with other people | 3.7 | 3.6 | 3.0 | 0.0 | 10.0 | 81 | 67.5 |
MDASI | Mean | SD * | Median | Min | Max |
---|---|---|---|---|---|
Part I 1 | 2.1 | 2.0 | 1.5 | 0.0 | 10.0 |
Part II 2 | 4.4 | 3.1 | 4.7 | 0.0 | 10.0 |
Total Average Symptom Score | 2.8 | 2.4 | 2.1 | 0.0 | 10.0 |
Measurement of Symptom Intensity α | |||
---|---|---|---|
Part I | Part II | Total Average Score | |
rho-Spearman | |||
Global Health Status/QOL | −0.426 * | −0.500 * | −0.491 * |
Functionality (higher score → better QOL) | |||
Physical | −0.380 * | −0.400 * | −0.418 * |
Role | −0.257 * | −0.387 * | −0.337 * |
Emotional | −0.560 * | −0.458 * | −0.549 * |
Cognitive | −0.600 * | −0.509 * | −0.596 * |
Social | −0.402 * | −0.470 * | −0.471 * |
Symptoms (lower score → better QOL) | |||
Fatigue | 0.571 * | 0.596 * | 0.622 * |
Nausea and vomiting | 0.488 * | 0.340 * | 0.470 * |
Pain | 0.436 * | 0.464 * | 0.493 * |
Dyspnea | 0.406 * | 0.356 * | 0.406 * |
Insomnia | 0.355 * | 0.238 * | 0.332 * |
Appetite loss | 0.456 * | 0.487 * | 0.508 * |
Constipation | 0.378 * | 0.321 * | 0.389 * |
Diarrhea | 0.214 * | 0.247 * | 0.256 * |
Financial difficulties | 0.245 * | 0.193 * | 0.253 * |
Global Health Status/QOL (Higher Score → Better QOL) | ||||
---|---|---|---|---|
Prognostic Factors | Unstandardized Factor β | 95% CI | p-Value | |
Gender (1:men, 2:women) | −4.03 | −11.02 | 2.95 | 0.255 |
Age (years) | −0.08 | −0.31 | 0.16 | 0.519 |
Marital status (1:Unmarried/Divorced/Widowed, 2:Married, Cohabitation) | 2.11 | −6.70 | 10.93 | 0.636 |
Εducation (1:Primary school, 2:Middle school, 3:High schoolο, 4:University) | 1.68 | −1.79 | 5.16 | 0.338 |
Living alone (1:yes, 2:no) | −0.23 | −11.23 | 10.76 | 0.967 |
Residence (1:urban, 2:rural) | 4.68 | −3.45 | 12.80 | 0.257 |
Time from diagnosis (months) | −0.05 | −0.12 | 0.02 | 0.191 |
Comorbidities (diseases) | −0.40 | −3.96 | 3.16 | 0.825 |
Total Average Symptom Score MDASI | −4.91 | −6.56 | −3.26 | <0.001 |
R2 (R2 adjusted) | 0.341 (0.287) |
Gender | Age | Marital Status | Education | Living Alone | Residence | Time Since Diagnosis | Comorbidities | |
---|---|---|---|---|---|---|---|---|
rho-Spearman | ||||||||
Global Health Status/QOL | −0.185 * | −0.145 | 0.057 | 0.176 | −0.051 | 0.092 | −0.059 | −0.160 |
Functionality (higher score → better QOL) | ||||||||
Physical | −0.096 | −0.331 * | 0.052 | 0.239 * | −0.019 | 0.009 | −0.199 * | −0.209 * |
Role | 0.002 | −0.232 * | 0.030 | 0. 099 | −0.031 | −0.010 | 0.016 | 0.011 |
Emotional | −0.150 | −0.192 * | -0.029 | 0.143 | −0.089 | 0.011 | −0.019 | −0.284 * |
Cognitive | −0.004 | −0.176 | -0.052 | 0.062 | −0.098 | −0.071 | −0.197 * | −0.173 |
Social | 0.012 | −0.167 | -0.029 | 0.124 | −0.099 | −0.081 | −0.199 * | −0.098 |
Symptoms (lower score → better QOL) | ||||||||
Fatigue | 0.057 | 0.277 * | 0.131 | −0.102 | 0.020 | −0.060 | 0.080 | 0.162 |
Nausea and vomiting | 0.196 * | −0.201 * | 0.023 | 0.036 | 0.059 | −0.190 * | −0.137 | 0.094 |
Pain | 0.114 | 0.073 | −0.085 | −0.167 | 0.016 | −0.061 | 0.115 | 0.192 * |
Dyspnea | 0.009 | 0.267 * | 0.027 | −0.175 | −0.043 | 0.016 | 0.103 | 0.232 * |
Insomnia | 0.136 | −0.008 | 0.085 | 0.003 | 0.014 | −0.087 | 0.000 | 0.165 |
Appetite loss | 0.034 | 0.083 | 0.068 | 0.050 | 0.084 | −0.169 | −0.066 | 0.130 |
Constipation | 0.160 | −0.052 | −0.008 | 0.038 | 0.038 | −0.132 | −0.227 * | 0.153 |
Diarrhea | −0.001 | 0.129 | −0.023 | −0.120 | 0.138 | 0.004 | 0.079 | 0.167 |
Financial difficulties | 0.011 | 0.091 | −0.168 | −0.081 | 0.015 | −0.021 | 0.237 * | 0.113 |
Gender | Age | Marital Status | Education | Living Alone | Residence | Time Since Diagnosis | Comorbidities | |
---|---|---|---|---|---|---|---|---|
rho-Spearman | ||||||||
Part I | 0.193 * | 0.088 | 0.062 | −0.154 | 0.150 | −0.063 | 0.109 | 0.220 * |
Part II | 0.080 | 0.145 | −0.015 | −0.131 | 0.156 | −0.054 | 0.036 | 0.085 |
Total Average Symptom Score | 0.163 | 0.108 | 0.005 | −0.134 | 0.156 | −0.075 | 0.076 | 0.179 * |
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Share and Cite
Konstantinidis, T.I.; Tsatsou, I.; Tsagkaraki, E.; Chasouraki, E.; Saridi, M.; Adamakidou, T.; Govina, O. Quality of Life and Symptoms of Hospitalized Hematological Cancer Patients. Curr. Oncol. 2024, 31, 6699-6710. https://doi.org/10.3390/curroncol31110494
Konstantinidis TI, Tsatsou I, Tsagkaraki E, Chasouraki E, Saridi M, Adamakidou T, Govina O. Quality of Life and Symptoms of Hospitalized Hematological Cancer Patients. Current Oncology. 2024; 31(11):6699-6710. https://doi.org/10.3390/curroncol31110494
Chicago/Turabian StyleKonstantinidis, Theocharis I., Ioanna Tsatsou, Eleftheria Tsagkaraki, Evgenia Chasouraki, Maria Saridi, Theodoula Adamakidou, and Ourania Govina. 2024. "Quality of Life and Symptoms of Hospitalized Hematological Cancer Patients" Current Oncology 31, no. 11: 6699-6710. https://doi.org/10.3390/curroncol31110494