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Current Oncology
Volume 32
Issue 5
10.3390/curroncol32050251
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Background:
Systematic Review

Molecular Prognostic Factors in Uterine Serous Carcinomas: A Systematic Review

by
Anna Svarna
*,
Michalis Liontos
,
Alkistis Papatheodoridi
,
Aristea-Maria Papanota
,
Eleni Zografos
,
Maria Kaparelou
,
Flora Zagouri
and
Meletios-Athanasios Dimopoulos
Department of Clinical Therapeutics, National and Kapodistrian University of Athens, Alexandra Hospital, V.Sofias 80, 11528 Athens, Greece
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2025, 32(5), 251; https://doi.org/10.3390/curroncol32050251
Submission received: 23 February 2025 / Revised: 5 April 2025 / Accepted: 22 April 2025 / Published: 25 April 2025
(This article belongs to the Section Gynecologic Oncology)
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Abstract

Uterine serous carcinomas are an aggressive minority of endometrial cancers. They are characterized by mutations in TP53 and extensive copy number alterations and are primarily classified in the copy number-high/p53abn molecular prognostic group, highlighting a unique molecular profile that is crucial for understanding their behavior and treatment responses. Clinical studies have shown that molecular categorization via biomarkers can facilitate proper treatment selection, and this is now widely used. In this context, the scope of this systematic review is to identify molecular characteristics with prognostic significance for these neoplasms to further inform on their treatment needs. We performed a comprehensive literature search of all articles written in English using the PubMed/Medline and Cochrane databases through February 2025. Our review led to the inclusion of 95 studies, from which we identified a total of 66 distinct molecular characteristics along with new cancer signatures that may impact prognosis. These findings have the potential to inform clinical practice by aiding in the development of tailored treatment strategies for patients with uterine serous carcinoma, ultimately improving outcomes in this challenging malignancy.
Keywords: serous uterine cancer; prognostic factors; biomarkers serous uterine cancer; prognostic factors; biomarkers

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MDPI and ACS Style

Svarna, A.; Liontos, M.; Papatheodoridi, A.; Papanota, A.-M.; Zografos, E.; Kaparelou, M.; Zagouri, F.; Dimopoulos, M.-A. Molecular Prognostic Factors in Uterine Serous Carcinomas: A Systematic Review. Curr. Oncol. 2025, 32, 251. https://doi.org/10.3390/curroncol32050251

AMA Style

Svarna A, Liontos M, Papatheodoridi A, Papanota A-M, Zografos E, Kaparelou M, Zagouri F, Dimopoulos M-A. Molecular Prognostic Factors in Uterine Serous Carcinomas: A Systematic Review. Current Oncology. 2025; 32(5):251. https://doi.org/10.3390/curroncol32050251

Chicago/Turabian Style

Svarna, Anna, Michalis Liontos, Alkistis Papatheodoridi, Aristea-Maria Papanota, Eleni Zografos, Maria Kaparelou, Flora Zagouri, and Meletios-Athanasios Dimopoulos. 2025. "Molecular Prognostic Factors in Uterine Serous Carcinomas: A Systematic Review" Current Oncology 32, no. 5: 251. https://doi.org/10.3390/curroncol32050251

APA Style

Svarna, A., Liontos, M., Papatheodoridi, A., Papanota, A.-M., Zografos, E., Kaparelou, M., Zagouri, F., & Dimopoulos, M.-A. (2025). Molecular Prognostic Factors in Uterine Serous Carcinomas: A Systematic Review. Current Oncology, 32(5), 251. https://doi.org/10.3390/curroncol32050251

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