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Pathophysiology
Volume 29
Issue 2
10.3390/pathophysiology29020018
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Article

Chronic Cannabis Intoxication and Propofol-Induced Salivation: Causes and Considerations

by
Allison Derise
1,†,
Carey Ford
1,†,
Nazar Hafiz
2,
Sudha Pandit
2,
Aditya Vyas
2,
Samuel Igbinedion
2,
James Morris
2,
Paul Jordan
2,
Qiang Cai
2 and
Jonathan Steven Alexander
1,2,3,*
1
School of Medicine, LSU Health Sciences, Shreveport, LA 71130, USA
2
Division of Gastroenterology and Hepatology, LSU Health Sciences, Shreveport, LA 71130, USA
3
Department of Molecular and Cellular Physiology, LSU Health Sciences, Shreveport, LA 71130, USA
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pathophysiology 2022, 29(2), 223-232; https://doi.org/10.3390/pathophysiology29020018
Submission received: 24 March 2022 / Revised: 16 May 2022 / Accepted: 19 May 2022 / Published: 28 May 2022
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Abstract

Legalization/decriminalization of cannabis will increase the numbers of patients who have had recent exposure to recreational or medical cannabis. Currently, little has been reported about potential interactions between cannabis use and Propofol anesthesia e.g., for oropharyngeal procedures. We describe three cases of ‘cannabis-induced hypersalivation after propofol’ (CHAP) and present our institutions’ experience with this unique pharmacological combination. Increased hypersalivation may complicate procedures and represent a procedural risk of suffocation. We evaluate possible pharmacological interactions that might underlie this phenomenon and consider management options going forward.
Keywords: cannabis; propofol; hypersalivation; sedation cannabis; propofol; hypersalivation; sedation

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MDPI and ACS Style

Derise, A.; Ford, C.; Hafiz, N.; Pandit, S.; Vyas, A.; Igbinedion, S.; Morris, J.; Jordan, P.; Cai, Q.; Alexander, J.S. Chronic Cannabis Intoxication and Propofol-Induced Salivation: Causes and Considerations. Pathophysiology 2022, 29, 223-232. https://doi.org/10.3390/pathophysiology29020018

AMA Style

Derise A, Ford C, Hafiz N, Pandit S, Vyas A, Igbinedion S, Morris J, Jordan P, Cai Q, Alexander JS. Chronic Cannabis Intoxication and Propofol-Induced Salivation: Causes and Considerations. Pathophysiology. 2022; 29(2):223-232. https://doi.org/10.3390/pathophysiology29020018

Chicago/Turabian Style

Derise, Allison, Carey Ford, Nazar Hafiz, Sudha Pandit, Aditya Vyas, Samuel Igbinedion, James Morris, Paul Jordan, Qiang Cai, and Jonathan Steven Alexander. 2022. "Chronic Cannabis Intoxication and Propofol-Induced Salivation: Causes and Considerations" Pathophysiology 29, no. 2: 223-232. https://doi.org/10.3390/pathophysiology29020018

APA Style

Derise, A., Ford, C., Hafiz, N., Pandit, S., Vyas, A., Igbinedion, S., Morris, J., Jordan, P., Cai, Q., & Alexander, J. S. (2022). Chronic Cannabis Intoxication and Propofol-Induced Salivation: Causes and Considerations. Pathophysiology, 29(2), 223-232. https://doi.org/10.3390/pathophysiology29020018

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