A Selective Fluorescence Turn-On Probe for the Detection of DCNP (Nerve Agent Tabun Simulant)
Abstract
:1. Introduction
2. Materials and Methods
2.1. Synthesis
2.2. UV/Vis Absorption and Fluorescence Assay
2.3. Sensing Application for DCNP-Moistened Soils
2.4. Sensing Kit Application
3. Results and Discussion
3.1. Sensing Ability of DMHN1 for DCNP
3.2. Sensing Application of DMHN1 for DCNP-Moistened Soils
3.3. Sensing Kit Test for Real-Time Detection of DCNP
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
DCNP | Diethylcyanophosphonate |
DCP | Diethyl chlorophosphate |
DMMP | Dimethyl methylphosphonate |
TPP | Tripropyl phosphate |
TEP | Triethyl phosphate |
GA | Tabun |
GB | Sarin |
GD | Soman |
CW | Chemical warfare |
ESIPT | Excited state intramolecular proton transfer |
CNS | Central nervous system |
AChE | Acetylcholinesterase |
ACN | Acetonitrile |
EtOH | Ethanol |
iPA | Isopropanol |
DMSO | Dimethyl sulfoxide |
DMF | N,N-dimethylformamide |
EtOAc | Ethyl acetate |
DI H2O | Deionized water |
DCM | Dichloromethane |
PTFE | Polytetrafluoroethylene |
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Probes | λex/λem (nm) Sensing Media) | Detection Limit | Selectivity | Reaction Condition (time) | Application | Reference |
---|---|---|---|---|---|---|
266/n.r. (CH3CN-H2O) | 30 ppm | ○ (Multi-sensing: DFP) | 25 °C (30 s) | Polyurethane membrane vapor test | [21] | |
475/n.r. (CH3CN-H₂O) | 0.9 mM | ○ (Multi-sensing: DCP) | 25 °C (10 min) | Polyurethane film vapor test | [22] | |
555/625 (CH3CN) | 0.91 ppm (visible), 0.36 ppm (Fl) | ○ (Multi-sensing: DFP) | 25 °C (n.r.) | Silica gel plate and polyethylene oxide membrane vapor test | [23] | |
410/n.r. (DMSO-TEA) | 3 mM | ○ (Multi-sensing: DCP) | 25 °C (60 min) | Chemogenic response test | [24] | |
530/555 (CH3CN-H₂O) | 2.7 ppm (in CH3CN) | ○ (Multi-sensing: DFP | 25 °C (n.r.) | Hydrogel coated polyethylene strip vapor test, silica strip test | [25] | |
530/575 (CH3CN) | 4.52 ppm (visible), 4.01 ppm(Fl) | ○ (Multi-sensing: DFP) | 25 °C (n.r.) | Silica gel plate test, polyethylene oxide membrane vapor test | [26] | |
499/508 (HEPES buffer) | 92.2 μM | ○ (Multi-sensing: DCP, DEMP) | n.r. | n.r. | [27] | |
470/507 (CH3CN) | 7 ppm (CH3CN), 4 ppm (H₂O-CH3CN) | ○ | 25 °C (~ s) | Hydrogel coated polyethylene strip vapor test | [28] | |
320, 410/486 (CH3CN-H₂O) | 3.09 μM | ○ (Relay sensing with F- ion) | 25 °C (~ s) | TLC plate emerging test | [29] | |
550/n.a. (Dioxane) | 1 mM | ○ | n.r. | Vapor test | [30] | |
345/375-395 (THF-H₂O) | 0.1 mM | ○ (Multi-sensing) | n.r. | Quartz plate vapor test | [31] | |
388/460 (CHCl3) | 0.044 nM (DCP) | × (selective for DCP) | 25 °C (5 min) | n.r. | [32] | |
365/430, 559 (DMSO-TEA) | 1.6 μM (DCP) | × (selective for DCP) | 25 °C (n.r.) | Vapor test | [33] | |
458/570 (PBS buffer) | 21.9 nM | ○ (Multi-sensing: DCP) | 25 °C (10 min) | Silica plate vapor test | [34] | |
550/635 (MES buffer) | 90.8 pM | × | 25 °C (10 min) | Water test | [35] | |
480/520 (DMF-TEA/ DMAP) | 20.7 ppb (DCP) | × (selective for DCP) | 25 °C (10 min) | Paper strip test | [36] | |
410/480 (DMF) | 1.3 nM | ○ | 25 °C (4 min) | Vapor test | [37] | |
465/550 (H₂O) | 10.8 μM | ○ | 25 °C (30 min) | Paper test vapor test | [38] | |
520/588 (CHCl3-TEA) | 88 nM (DCP) 72 μM (Phosgene) | ○ | 25 °C (2 min) | Polystyrene membrane vapor test | [39] |
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Jung, Y.; Kim, D. A Selective Fluorescence Turn-On Probe for the Detection of DCNP (Nerve Agent Tabun Simulant). Materials 2019, 12, 2943. https://doi.org/10.3390/ma12182943
Jung Y, Kim D. A Selective Fluorescence Turn-On Probe for the Detection of DCNP (Nerve Agent Tabun Simulant). Materials. 2019; 12(18):2943. https://doi.org/10.3390/ma12182943
Chicago/Turabian StyleJung, Yuna, and Dokyoung Kim. 2019. "A Selective Fluorescence Turn-On Probe for the Detection of DCNP (Nerve Agent Tabun Simulant)" Materials 12, no. 18: 2943. https://doi.org/10.3390/ma12182943