A Facile Synthesis of Core-Shell SiO2@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Methods
2.2.1. Preparation of Cu-LBMS
2.2.2. Preparation of SiO2 Microspheres
2.2.3. Hybrid Assembly of Cu-LBMS with SiO2 Microspheres
2.2.4. Preparation of the Drug-Loaded SiO2@Cu-LBMS and Drug-Loaded Cu-LBMS
2.2.5. In vitro Drug Cumulative Release Studies
2.2.6. Characterization
3. Results and Discussion
3.1. The Morphology of SiO2@Cu-LBMS
3.2. Hybrid Assembly Process of Cu-LBMS and SiO2
3.3. Preparation of SiO2@Cu-LBMS Nanocomposite
3.4. The Physicochemical Properties of SiO2@Cu-LBMS Microspheres
3.5. The Drug Loading Property of SiO2@Cu-LBMS Microspheres
3.6. The Effects of SiO2@Cu-LBMS Microspheres on Drug Release Behavior
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Materials | Ibuprofen (mg/g) | Aspirin (mg/g) | Salicylic Acid(mg/g) |
---|---|---|---|
SiO2@Cu-LBMS | 263.16 | 380.14 | 362.23 |
Cu-LBMS | 160.05 | 300.02 | 254.13 |
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Wang, H.; Yang, H.; Zhao, L. A Facile Synthesis of Core-Shell SiO2@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems. Materials 2019, 12, 3978. https://doi.org/10.3390/ma12233978
Wang H, Yang H, Zhao L. A Facile Synthesis of Core-Shell SiO2@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems. Materials. 2019; 12(23):3978. https://doi.org/10.3390/ma12233978
Chicago/Turabian StyleWang, Hui, Haifeng Yang, and Lifang Zhao. 2019. "A Facile Synthesis of Core-Shell SiO2@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems" Materials 12, no. 23: 3978. https://doi.org/10.3390/ma12233978
APA StyleWang, H., Yang, H., & Zhao, L. (2019). A Facile Synthesis of Core-Shell SiO2@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems. Materials, 12(23), 3978. https://doi.org/10.3390/ma12233978