A Biodegradable Antifungal-Loaded Sol–Gel Coating for the Prevention and Local Treatment of Yeast Prosthetic-Joint Infections
Abstract
:1. Introduction
2. Materials and Methods
2.1. Preparation of Sol–Gel Coatings and Substrates
2.2. Surface Characterization
2.3. Kinetics Study of Antifungal Release
2.4. Selection and Maintenance of Strains for Microbiological Study
2.5. Adherence Study
2.6. Evaluation of Biofilm Formation Inhibition
2.7. Evaluation of the Treatment of Mature Biofilms
2.8. Cellular Study
2.9. Statistical Analysis
3. Results
3.1. Synthesis of the Coatings and Surface Characterization
3.2. Drug-Release Study
3.3. Adherence Study
3.4. Prevention of Biofilm Formation
3.5. Evaluation of Treatment of Mature Biofilms
3.6. Cytotoxicity and Proliferation Assays
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Romera, D.; Toirac, B.; Aguilera-Correa, J.-J.; García-Casas, A.; Mediero, A.; Jiménez-Morales, A.; Esteban, J. A Biodegradable Antifungal-Loaded Sol–Gel Coating for the Prevention and Local Treatment of Yeast Prosthetic-Joint Infections. Materials 2020, 13, 3144. https://doi.org/10.3390/ma13143144
Romera D, Toirac B, Aguilera-Correa J-J, García-Casas A, Mediero A, Jiménez-Morales A, Esteban J. A Biodegradable Antifungal-Loaded Sol–Gel Coating for the Prevention and Local Treatment of Yeast Prosthetic-Joint Infections. Materials. 2020; 13(14):3144. https://doi.org/10.3390/ma13143144
Chicago/Turabian StyleRomera, David, Beatriz Toirac, John-Jairo Aguilera-Correa, Amaya García-Casas, Aránzazu Mediero, Antonia Jiménez-Morales, and Jaime Esteban. 2020. "A Biodegradable Antifungal-Loaded Sol–Gel Coating for the Prevention and Local Treatment of Yeast Prosthetic-Joint Infections" Materials 13, no. 14: 3144. https://doi.org/10.3390/ma13143144