Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Tablet Preparation, Hydration and Spatial Sampling
2.3. Spatial Distribution of Water Content within the Matrix Tablets Using Karl Fischer Titration
2.4. Differential Scanning Calorimetry
2.5. Magnetic Resonance Imaging and Image Analysis
2.6. X-ray Microtomography
2.7. Drug Dissolution Study
3. Results
3.1. Characteristics of ALG/SA Tablets
3.2. Characteristics of ALG/SNA Tablets
3.3. Discussion with Reference to Alginate (Placebo) Matrix
4. Conclusions
- “locking” of the internal part of the matrix (ALG/SA);
- existence of lamellar region associated with detection of free/freezing water (ALG/SA);
- existence of water penetrating the matrix, forming a specific layer preceding the infiltration layer (ALG/SNA);
- switch in the onset temperature of endothermic water peak associated with an increase in the fraction of non-freezing water weight per dry matrix weight in the middle of infiltration layer (ALG/SNA);
- the region denoted as infiltration layer is characterized by a high gradient in magnetic resonance signal intensity (proton density) and lower X-ray absorbance (mainly lower density) when compared with the core.
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Juszczyk, E.; Kulinowski, P.; Baran, E.; Birczyński, A.; Klaja, J.; Majda, D.; Garcia-Montoya, E.; Węglarz, W.P.; Dorożyński, P. Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation. Materials 2021, 14, 6531. https://doi.org/10.3390/ma14216531
Juszczyk E, Kulinowski P, Baran E, Birczyński A, Klaja J, Majda D, Garcia-Montoya E, Węglarz WP, Dorożyński P. Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation. Materials. 2021; 14(21):6531. https://doi.org/10.3390/ma14216531
Chicago/Turabian StyleJuszczyk, Ewelina, Piotr Kulinowski, Ewelina Baran, Artur Birczyński, Jolanta Klaja, Dorota Majda, Encarna Garcia-Montoya, Władysław P. Węglarz, and Przemysław Dorożyński. 2021. "Hydration Patterns in Sodium Alginate Polymeric Matrix Tablets—The Result of Drug Substance Incorporation" Materials 14, no. 21: 6531. https://doi.org/10.3390/ma14216531