A Randomized Controlled Trial of Guided Bone Regeneration for Peri-Implant Dehiscence Defects with Two Anorganic Bovine Bone Materials Covered by Titanium Meshes
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Selection
2.2. Surgical Procedure
2.3. Evaluation of Grafted Volume
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
- A peri-implant dehiscence defect was successfully reconstructed by GBR with double-layering of allograft and ABBM, which were covered by a preformed ultrafine titanium mesh and an absorbable collagen membrane;
- Despite the volume maintenance effect of ABBMs, approximately 27.8% of grafted volume resorption was noted at T2, and there was no significant difference between the Bio-Oss and A-Oss groups, even in the quality of the regenerated bone;
- The grafted volume loss (approximately 43.2%) continued up to T3 and did not differ between the Bio-Oss and A-Oss groups.
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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ABBMs | Patient | Site (FDI) | Implant Body (mm) | Defect Size (mm) | Grafted Volume (cc) | Probing Depth (mm) | Titanium Mesh | Collagen Membrane | Sequelae | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sex (M:F) | Age (Year) | Width | Length | Width | Length | T0 | T1 | T2 | T3 | C:H | Type 1:2 | OG:OM | Class I:II | ||||
Bio-Oss group | 1 | F | 63 | 36 | 5 | 7 | 6 | 3 | 1.14 | 0.91 | 0.80 | 3.5 | H | 2 | M | ||
2 | Dropped | ||||||||||||||||
3 | M | 56 | 16 | 4.5 | 8.5 | 5 | 4.5 | 1.53 | 1.11 | 0.89 | 2 | H | 1 | G | |||
4 | M | 60 | 23 | 4 | 8.5 | 6.5 | 4.5 | 1.91 | 1.40 | 1.10 | 3 | C | 2 | G | I | ||
5 | F | 54 | 42 | 4 | 8.5 | 4 | 4 | 0.00 | 1.16 | 0.83 | 0.60 | 2.5 | H | 1 | M | ||
6 | F | 55 | 11 | 4 | 10 | 4 | 4 | 2.41 | 1.32 | 0.85 | 3 | H | 1 | M | |||
7 | M | 51 | 16 | 4.5 | 8.5 | 4.5 | 3 | 1.33 | 0.91 | 0.67 | 2 | H | 1 | G | |||
8 | F | 28 | 12 | 4 | 8.5 | 5.5. | 3 | 2.37 | 1.94 | 1.75 | 2 | C | 2 | M | |||
9 | F | 63 | 46 | 5 | 7 | 7 | 4 | 1.72 | 0.91 | 0.70 | 4 | C | 2 | M | II | ||
A-Oss group | 1 | M | 30 | 46 | 5 | 10 | 5 | 3 | 1.53 | 1.29 | 1.17 | 3 | H | 1 | G | ||
2 | F | 54 | 16 | 4.5 | 8.5 | 6.5 | 5 | 2.04 | 1.51 | 1.20 | 3.5 | H | 2 | G | |||
3 | M | 50 | 42 | 4 | 8.5 | 6 | 3.5 | 1.98 | 1.67 | 1.25 | 2 | C | 2 | M | |||
4 | Dropped | ||||||||||||||||
5 | M | 53 | 35 | 4 | 10 | 6 | 6 | 0.00 | 1.73 | 1.39 | 1.18 | 2 | H | 2 | M | ||
6 | F | 64 | 15 | 4 | 8.5 | 6 | 7 | 2.12 | 1.60 | 1.37 | 2 | H | 2 | G | |||
7 | F | 65 | 25 | 4 | 10 | 6.5 | 2.5 | 1.73 | 1.29 | 1.18 | 1.5 | C | 2 | M | |||
8 | F | 72 | 21 | 4 | 8.5 | 4 | 5.5 | 2.03 | 1.42 | 0.87 | 3 | H | 1 | M | |||
9 | M | 50 | 33 | 4 | 8.5 | 6 | 4 | 2.33 | 1.51 | 0.97 | 4 | C | 2 | M | I |
Variables | Bio-Oss | A-Oss | p-Value | |
---|---|---|---|---|
Sex | (Male) | 3 (37.5) | 4 (50.0) | 0.6143 |
(Female) | 5 (62.5) | 4 (50.0) | ||
Age | (Years) | 53.8 ± 10.8 | 54.8 ± 12.2 | 0.9258 |
Surgical site | (Maxilla) | 5 (62.5) | 4 (50.0) | 0.6143 |
(Mandible) | 3 (37.5) | 4 (50.0) | ||
(Anterior) | 4 (50.0) | 3 (37.5) | 0.6143 | |
(Posterior) | 4 (50.0) | 5 (62.5) | ||
Defect | (Width) | 5.3 ± 1.1 | 5.8 ± 0.8 | 0.1542 |
(Height) | 3.8 ± 0.6 | 4.6 ± 1.5 | 0.0892 | |
Implant (mm) | (Width) | 4.4 ± 0.4 | 4.2 ± 0.4 | 0.0850 |
(Length) | 8.3 ± 0.9 | 9.1 ± 0.7 | 0.0050 * | |
Probing depth (mm) | (mm) | 2.8 ± 0.7 | 2.6 ± 0.8 | 0.5001 |
Titanium mesh | (Cover cap) | 3 (37.5) | 4 (50.0) | 0.6143 |
(Healing cap) | 5 (62.5) | 4 (50.0) | ||
Type I (Buccal only) | 4 (50.0) | 2 (25.0) | 0.2369 | |
Type II (Bucco-proximal) | 4 (50.0) | 6 (75.0) | ||
Sequelae | (Yes) | 2 (25.0) | 1 (12.5) | 0.4103 |
Estimates | T Value | p-Value | |
---|---|---|---|
T2—T3 | −0.2244 | −5.02 | 0.0007 * |
T2—T1 | −2.3194 | −15.62 | <0.0001 * |
T3—T1 | −2.0950 | −16.87 | <0.0001 * |
Effects | Estimates | T Value | p-Value | |
---|---|---|---|---|
Group | −0.2112 | −1.12 | 0.2906 | |
Time | (T2) | −2.4125 | −11.49 | <0.0001 *** |
(T3) | −2.2475 | −12.80 | <0.0001 *** | |
Group × Time † | (T2) | 0.1863 | 0.63 | 0.5460 |
(T3) | 0.3050 | 1.23 | 0.2505 | |
Age | −0.0045 | −4.17 | 0.0024 ** | |
Sequelae | (Yes) | −0.1184 | −2.79 | 0.0210 * |
Defect | (Width) | 0.0796 | 4.58 | 0.0013 ** |
Surgical site | (Posterior) | −0.0624 | −2.17 | 0.0583 |
(Maxilla) | 0.0684 | 2.77 | 0.0218 * |
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Lim, J.; Jun, S.H.; Tallarico, M.; Park, J.-B.; Park, D.-H.; Hwang, K.-G.; Park, C.-J. A Randomized Controlled Trial of Guided Bone Regeneration for Peri-Implant Dehiscence Defects with Two Anorganic Bovine Bone Materials Covered by Titanium Meshes. Materials 2022, 15, 5294. https://doi.org/10.3390/ma15155294
Lim J, Jun SH, Tallarico M, Park J-B, Park D-H, Hwang K-G, Park C-J. A Randomized Controlled Trial of Guided Bone Regeneration for Peri-Implant Dehiscence Defects with Two Anorganic Bovine Bone Materials Covered by Titanium Meshes. Materials. 2022; 15(15):5294. https://doi.org/10.3390/ma15155294
Chicago/Turabian StyleLim, JaeHyung, Sang Ho Jun, Marco Tallarico, Jun-Beom Park, Dae-Ho Park, Kyung-Gyun Hwang, and Chang-Joo Park. 2022. "A Randomized Controlled Trial of Guided Bone Regeneration for Peri-Implant Dehiscence Defects with Two Anorganic Bovine Bone Materials Covered by Titanium Meshes" Materials 15, no. 15: 5294. https://doi.org/10.3390/ma15155294