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10.3390/ma15207136
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Article

Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin

by
Alexander A. Artyukhov
1,
Anna M. Nechaeva
1,
Mikhail I. Shtilman
1,
Evgeniy M. Chistyakov
1,
Alina Yu. Svistunova
1,
Dmitry V. Bagrov
2,
Andrey N. Kuskov
1,
Anca O. Docea
3,
Aristides M. Tsatsakis
4,
Leonid Gurevich
5,* and
Yaroslav O. Mezhuev
1,*
1
Department of Biomaterials, Mendeleev University of Chemical Technology of Russia, 125047 Moscow, Russia
2
Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia
3
Department of Toxicology, Faculty of Pharmacy, University of Medicine & Pharmacy, 2 Petru Rares, 200349 Craiova, Romania
4
Center of Toxicology Science & Research, Division of Morphology, Medical School, University of Crete, Voutes Campus, 71003 Heraklion, Greece
5
Department of Materials and Production, Aalborg University, Skjernvej 4A, 9220 Aalborg, Denmark
*
Authors to whom correspondence should be addressed.
Materials 2022, 15(20), 7136; https://doi.org/10.3390/ma15207136
Submission received: 7 September 2022 / Revised: 4 October 2022 / Accepted: 9 October 2022 / Published: 13 October 2022
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Abstract

Application of nanocarriers for drug delivery brings numerous advantages, allowing both minimization of side effects common in systemic drug delivery and improvement in targeting, which has made it the focal point of nanoscience for a number of years. While most of the studies are focused on encapsulation of hydrophobic drugs, delivery of hydrophilic compounds is typically performed via covalent attachment, which often requires chemical modification of the drug and limits the release kinetics. In this paper, we report synthesis of biphilic copolymers of various compositions capable of self-assembly in water with the formation of nanoparticles and suitable for ionic binding of the common anticancer drug doxorubicin. The copolymers are synthesized by radical copolymerization of N-vinyl-2-pyrrolidone and acrylic acid using n-octadecyl-mercaptan as a chain transfer agent. With an increase of the carboxyl group’s share in the chain, the role of the electrostatic stabilization factor of the nanoparticles increased as well as the ability of doxorubicin as an ion binder. A mathematical description of the kinetics of doxorubicin binding and release is given and thermodynamic functions for the equilibrium ionic binding of doxorubicin are calculated.
Keywords: targeting; doxorubicin delivery; release kinetics; poly(N-vinyl-2-pyrrolidone-co-acrylic acid) nanoparticles targeting; doxorubicin delivery; release kinetics; poly(N-vinyl-2-pyrrolidone-co-acrylic acid) nanoparticles

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MDPI and ACS Style

Artyukhov, A.A.; Nechaeva, A.M.; Shtilman, M.I.; Chistyakov, E.M.; Svistunova, A.Y.; Bagrov, D.V.; Kuskov, A.N.; Docea, A.O.; Tsatsakis, A.M.; Gurevich, L.; et al. Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin. Materials 2022, 15, 7136. https://doi.org/10.3390/ma15207136

AMA Style

Artyukhov AA, Nechaeva AM, Shtilman MI, Chistyakov EM, Svistunova AY, Bagrov DV, Kuskov AN, Docea AO, Tsatsakis AM, Gurevich L, et al. Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin. Materials. 2022; 15(20):7136. https://doi.org/10.3390/ma15207136

Chicago/Turabian Style

Artyukhov, Alexander A., Anna M. Nechaeva, Mikhail I. Shtilman, Evgeniy M. Chistyakov, Alina Yu. Svistunova, Dmitry V. Bagrov, Andrey N. Kuskov, Anca O. Docea, Aristides M. Tsatsakis, Leonid Gurevich, and et al. 2022. "Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin" Materials 15, no. 20: 7136. https://doi.org/10.3390/ma15207136

APA Style

Artyukhov, A. A., Nechaeva, A. M., Shtilman, M. I., Chistyakov, E. M., Svistunova, A. Y., Bagrov, D. V., Kuskov, A. N., Docea, A. O., Tsatsakis, A. M., Gurevich, L., & Mezhuev, Y. O. (2022). Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin. Materials, 15(20), 7136. https://doi.org/10.3390/ma15207136

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