Double-Reinforced Fish Gelatin Composite Scaffolds for Osteochondral Substitutes
Abstract
:1. Introduction
2. Materials and Methods
2.1. Materials
2.2. Composite Blend Synthesis
2.3. Methods
2.3.1. Mechanical Testing
2.3.2. Micro-Computer Tomography
2.3.3. Swelling Behavior
2.3.4. Enzyme Degradation Study
2.3.5. In Vitro Biocompatibility
3. Results and Discussion
3.1. Causal Links between Composition-Mechanics-Architecture Fluidity
3.2. Impact of Mechanics and Architecture on In Vitro Performance in Simulated Media
3.3. In Vitro Cytocompatibility
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Sample | fGκC | fGκC_GO1 | fGκC_GO2 | fGκC_GO3 | fGκC_GO4 | fGκC_GO5 |
---|---|---|---|---|---|---|
Total porosity [%] | 86.9 | 88.2 | 88.8 | 88.5 | 88.9 | 87.7 |
Pores 150–300 µm | 40.5 | 24.5 | 14.8 | 21.3 | 17.9 | 25.9 |
Pores 200–500 µm | 60.67 | 71.3 | 59.2 | 66.1 | 72.0 | 70.2 |
Mean pore size [µm] | 239 | 299 | 398 | 338 | 340 | 286 |
Mean wall size [µm] | 28 | 27 | 31 | 28 | 27 | 31 |
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Toader, A.G.; Vlasceanu, G.M.; Serafim, A.; Banciu, A.; Ionita, M. Double-Reinforced Fish Gelatin Composite Scaffolds for Osteochondral Substitutes. Materials 2023, 16, 1815. https://doi.org/10.3390/ma16051815
Toader AG, Vlasceanu GM, Serafim A, Banciu A, Ionita M. Double-Reinforced Fish Gelatin Composite Scaffolds for Osteochondral Substitutes. Materials. 2023; 16(5):1815. https://doi.org/10.3390/ma16051815
Chicago/Turabian StyleToader, Alin Georgian, George Mihail Vlasceanu, Andrada Serafim, Adela Banciu, and Mariana Ionita. 2023. "Double-Reinforced Fish Gelatin Composite Scaffolds for Osteochondral Substitutes" Materials 16, no. 5: 1815. https://doi.org/10.3390/ma16051815