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Hydrogels for Neural Regeneration: Exploring New Horizons
by
Hossein Omidian
Hossein Omidian *
,
Sumana Dey Chowdhury
Sumana Dey Chowdhury
and
Luigi X. Cubeddu
Luigi X. Cubeddu
Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA
*
Author to whom correspondence should be addressed.
Materials 2024, 17(14), 3472; https://doi.org/10.3390/ma17143472 (registering DOI)
Submission received: 24 June 2024
/
Revised: 6 July 2024
/
Accepted: 11 July 2024
/
Published: 13 July 2024
Abstract
Abstract: Nerve injury can significantly impair motor, sensory, and autonomic functions. Understanding nerve degeneration, particularly Wallerian degeneration, and the mechanisms of nerve regeneration is crucial for developing effective treatments. This manuscript reviews the use of advanced hydrogels that have been researched to enhance nerve regeneration. Hydrogels, due to their biocompatibility, tunable properties, and ability to create a supportive microenvironment, are being explored for their effectiveness in nerve repair. Various types of hydrogels, such as chitosan-, alginate-, collagen-, hyaluronic acid-, and peptide-based hydrogels, are discussed for their roles in promoting axonal growth, functional recovery, and myelination. Advanced formulations incorporating growth factors, bioactive molecules, and stem cells show significant promise in overcoming the limitations of traditional therapies. Despite these advancements, challenges in achieving robust and reliable nerve regeneration remain, necessitating ongoing research to optimize hydrogel-based interventions for neural regeneration.
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MDPI and ACS Style
Omidian, H.; Chowdhury, S.D.; Cubeddu, L.X.
Hydrogels for Neural Regeneration: Exploring New Horizons. Materials 2024, 17, 3472.
https://doi.org/10.3390/ma17143472
AMA Style
Omidian H, Chowdhury SD, Cubeddu LX.
Hydrogels for Neural Regeneration: Exploring New Horizons. Materials. 2024; 17(14):3472.
https://doi.org/10.3390/ma17143472
Chicago/Turabian Style
Omidian, Hossein, Sumana Dey Chowdhury, and Luigi X. Cubeddu.
2024. "Hydrogels for Neural Regeneration: Exploring New Horizons" Materials 17, no. 14: 3472.
https://doi.org/10.3390/ma17143472
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