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Article

Novel Collagen Membrane Formulations with Irinotecan or Minocycline for Potential Application in Brain Cancer

by
Andreea-Anamaria Idu
1,2,
Mădălina Georgiana Albu Kaya
3,
Ileana Rău
1,*,
Nicoleta Radu
4,5,
Cristina-Elena Dinu-Pîrvu
6,7 and
Mihaela Violeta Ghica
6,7
1
Department of General Chemistry, Faculty ‬of ‬Chemical ‬Engineering ‬and ‬Biotechnologies, ‬National ‬University ‬of ‬Science ‬and ‬Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania
2
Department of Neurosurgery, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
3
Collagen Department, INCDTP—Division Leather and Footwear Research Institute, 93 Ion Minulescu Str., 031215 Bucharest, Romania
4
Faculty of Biotechnology, University of Agronomic Sciences and Veterinary Medicine of Bucharest Romania, 59 Bulevardul Marasti, 011464 Bucharest, Romania
5
Biotechnology Department, National Institute of Chemistry and Petrochemistry R&D of Bucharest, 202 Splaiul Independentei, 060021 Bucharest, Romania
6
Department of Physical and Colloidal Chemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania
7
Innovative Therapeutic Structures R&D Center (InnoTher), “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Materials 2024, 17(14), 3510; https://doi.org/10.3390/ma17143510
Submission received: 18 May 2024 / Revised: 3 July 2024 / Accepted: 12 July 2024 / Published: 15 July 2024

Abstract

Our study explores the development of collagen membranes with integrated minocycline or irinotecan, targeting applications in tissue engineering and drug delivery systems. Type I collagen, extracted from bovine skin using advanced fibril-forming technology, was crosslinked with glutaraldehyde to create membranes. These membranes incorporated minocycline, an antibiotic, or irinotecan, a chemotherapeutic agent, in various concentrations. The membranes, varying in drug concentration, were studied by water absorption and enzymatic degradation tests, demonstrating a degree of permeability. We emphasize the advantages of local drug delivery for treating high-grade gliomas, highlighting the targeted approach’s efficacy in reducing systemic adverse effects and enhancing drug bioavailability at the tumor site. The utilization of collagen membranes is proposed as a viable method for local drug delivery. Irinotecan’s mechanism, a topoisomerase I inhibitor, and minocycline’s broad antibacterial spectrum and inhibition of glial cell-induced membrane degradation are discussed. We critically examine the challenges posed by the systemic administration of chemotherapeutic agents, mainly due to the blood–brain barrier’s restrictive nature, advocating for local delivery methods as a more effective alternative for glioblastoma treatment. These local delivery strategies, including collagen membranes, are posited as significant advancements in enhancing therapeutic outcomes for glioblastoma patients.
Keywords: nanotechnology; bioengineering; glioblastoma; irinotecan; minocycline; collagen-based membranes nanotechnology; bioengineering; glioblastoma; irinotecan; minocycline; collagen-based membranes

Share and Cite

MDPI and ACS Style

Idu, A.-A.; Albu Kaya, M.G.; Rău, I.; Radu, N.; Dinu-Pîrvu, C.-E.; Ghica, M.V. Novel Collagen Membrane Formulations with Irinotecan or Minocycline for Potential Application in Brain Cancer. Materials 2024, 17, 3510. https://doi.org/10.3390/ma17143510

AMA Style

Idu A-A, Albu Kaya MG, Rău I, Radu N, Dinu-Pîrvu C-E, Ghica MV. Novel Collagen Membrane Formulations with Irinotecan or Minocycline for Potential Application in Brain Cancer. Materials. 2024; 17(14):3510. https://doi.org/10.3390/ma17143510

Chicago/Turabian Style

Idu, Andreea-Anamaria, Mădălina Georgiana Albu Kaya, Ileana Rău, Nicoleta Radu, Cristina-Elena Dinu-Pîrvu, and Mihaela Violeta Ghica. 2024. "Novel Collagen Membrane Formulations with Irinotecan or Minocycline for Potential Application in Brain Cancer" Materials 17, no. 14: 3510. https://doi.org/10.3390/ma17143510

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