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Open AccessArticle
Development of a Novel Cyclodextrin–Chitosan Polymer for an Efficient Removal of Pharmaceutical Contaminants in Aqueous Solution
by
Fadila Oughlis-Hammache
Fadila Oughlis-Hammache 1,2,3,*,
Mohamed Skiba
Mohamed Skiba 1,*
,
Lamia Moulahcene
Lamia Moulahcene 1,2,4,
Nicolas Milon
Nicolas Milon 1,
Frédéric Bounoure
Frédéric Bounoure 1 and
Malika Lahiani-Skiba
Malika Lahiani-Skiba 1
1
Normandie Univ, UNIROUEN, Galenic Pharmaceutical Laboratory, NorDIC Inserm U1239, UFR Medicine and Pharmacy, Rouen University, 22 Bd Gambetta, F-76183 Rouen, France
2
Laboratory of Membrane Processes and of Separation and Recovery Techniques, Faculty of Technology, Abderrahmane Mira University, Route de Targua Ouzemmour, Bejaia DZ-06000, Algeria
3
Faculty of Science and Applied Sciences, Department of Process Engineering, Akli Mohand Oulhadj University, Bouira 10000, Algeria
4
Institute of Technology, Department of Process Engineering, Akli Mohand Oulhadj University, Bouira 10000, Algeria
*
Authors to whom correspondence should be addressed.
Materials 2024, 17(14), 3594; https://doi.org/10.3390/ma17143594 (registering DOI)
Submission received: 14 May 2024
/
Revised: 17 July 2024
/
Accepted: 19 July 2024
/
Published: 21 July 2024
Abstract
A novel polymer synthesized by grafting three cyclodextrins onto chitosan was characterized and evaluated for its potential to adsorb two pharmaceutical residues: ibuprofen and progesterone. The influence of various operational parameters, including contact time, initial molecule concentration, pH, ionic strength, and temperature, was investigated. The synthesized polymer exhibits an amorphous and porous structure with a remarkable swelling capacity of 9.5 mmol/g. It demonstrates remarkable adsorption capacities for progesterone and ibuprofen, reaching 90% and 75%, respectively. Kinetic studies reveal that the adsorption of both molecules follows a pseudo-second-order model. A DSC analysis elucidated the adsorption mechanism, which is governed by the formation of inclusion complexes and electrostatic interactions within the polymer network. The polymer’s regeneration after 23 cycles demonstrates its sustainable adsorption efficiency. The combination of chitosan with three cyclodextrins opens up promising new avenues for water treatment and the removal of specific pollutants. This approach significantly improves the material’s selectivity towards target pollutants, offering a significant advantage in pollution remediation applications.
Share and Cite
MDPI and ACS Style
Oughlis-Hammache, F.; Skiba, M.; Moulahcene, L.; Milon, N.; Bounoure, F.; Lahiani-Skiba, M.
Development of a Novel Cyclodextrin–Chitosan Polymer for an Efficient Removal of Pharmaceutical Contaminants in Aqueous Solution. Materials 2024, 17, 3594.
https://doi.org/10.3390/ma17143594
AMA Style
Oughlis-Hammache F, Skiba M, Moulahcene L, Milon N, Bounoure F, Lahiani-Skiba M.
Development of a Novel Cyclodextrin–Chitosan Polymer for an Efficient Removal of Pharmaceutical Contaminants in Aqueous Solution. Materials. 2024; 17(14):3594.
https://doi.org/10.3390/ma17143594
Chicago/Turabian Style
Oughlis-Hammache, Fadila, Mohamed Skiba, Lamia Moulahcene, Nicolas Milon, Frédéric Bounoure, and Malika Lahiani-Skiba.
2024. "Development of a Novel Cyclodextrin–Chitosan Polymer for an Efficient Removal of Pharmaceutical Contaminants in Aqueous Solution" Materials 17, no. 14: 3594.
https://doi.org/10.3390/ma17143594
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