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10.3390/ma17246027
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Article

Preparation of Alginate Hydrogel Beads on a Superhydrophobic Surface with Calcium Salt Powder to Enhance the Mechanical Strength and Encapsulation Efficiency of Ingredients

by
Yuhei Hosokawa
1,
Takashi Goshima
1,
Takami Kai
1,
Saki Kobaru
1,
Yoshihiro Ohzuno
1,
Susumu Nii
1,
Shiro Kiyoyama
2,
Masahiro Yoshida
1 and
Takayuki Takei
1,*
1
Department of Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan
2
Department of Chemical Science and Engineering, National Institute of Technology, Miyakonojo College, 473-1 Yoshio, Miyazaki 885-8567, Japan
*
Author to whom correspondence should be addressed.
Materials 2024, 17(24), 6027; https://doi.org/10.3390/ma17246027
Submission received: 31 October 2024 / Revised: 28 November 2024 / Accepted: 4 December 2024 / Published: 10 December 2024
(This article belongs to the Special Issue Advanced Characterization of Biochemical Materials)
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Abstract

Calcium alginate hydrogel is one of the most widely used materials for drug-carrier beads used in drug-delivery systems. In this study, we developed a new method to improve the encapsulation efficiency of ingredients, such as medicines, in calcium alginate hydrogel beads. In the gold standard method, the hydrogel beads are prepared in the liquid phase. In contrast, in the new method, to enhance the encapsulation efficiency, the hydrogel beads are prepared in the gas phase using a water-repellent surface. In brief, a droplet of sodium alginate aqueous solution is rolled on a water-repellent surface with CaCl2 powder, a cross-linking agent. This process leads to the direct attachment of CaCl2 powder to the droplet, resulting in the formation of spherical hydrogel beads with high mechanical strength and higher encapsulation efficiency than beads prepared by previous methods. The hydrogel beads exhibit similar permeability for glucose, a model for low-molecular-weight medicines, to those prepared by previous methods. These results show that the new method is promising for the preparation of calcium alginate hydrogel beads for drug-delivery systems.
Keywords: hydrogel; bead; capsule; alginate; drug; water-repellent surface hydrogel; bead; capsule; alginate; drug; water-repellent surface
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MDPI and ACS Style

Hosokawa, Y.; Goshima, T.; Kai, T.; Kobaru, S.; Ohzuno, Y.; Nii, S.; Kiyoyama, S.; Yoshida, M.; Takei, T. Preparation of Alginate Hydrogel Beads on a Superhydrophobic Surface with Calcium Salt Powder to Enhance the Mechanical Strength and Encapsulation Efficiency of Ingredients. Materials 2024, 17, 6027. https://doi.org/10.3390/ma17246027

AMA Style

Hosokawa Y, Goshima T, Kai T, Kobaru S, Ohzuno Y, Nii S, Kiyoyama S, Yoshida M, Takei T. Preparation of Alginate Hydrogel Beads on a Superhydrophobic Surface with Calcium Salt Powder to Enhance the Mechanical Strength and Encapsulation Efficiency of Ingredients. Materials. 2024; 17(24):6027. https://doi.org/10.3390/ma17246027

Chicago/Turabian Style

Hosokawa, Yuhei, Takashi Goshima, Takami Kai, Saki Kobaru, Yoshihiro Ohzuno, Susumu Nii, Shiro Kiyoyama, Masahiro Yoshida, and Takayuki Takei. 2024. "Preparation of Alginate Hydrogel Beads on a Superhydrophobic Surface with Calcium Salt Powder to Enhance the Mechanical Strength and Encapsulation Efficiency of Ingredients" Materials 17, no. 24: 6027. https://doi.org/10.3390/ma17246027

APA Style

Hosokawa, Y., Goshima, T., Kai, T., Kobaru, S., Ohzuno, Y., Nii, S., Kiyoyama, S., Yoshida, M., & Takei, T. (2024). Preparation of Alginate Hydrogel Beads on a Superhydrophobic Surface with Calcium Salt Powder to Enhance the Mechanical Strength and Encapsulation Efficiency of Ingredients. Materials, 17(24), 6027. https://doi.org/10.3390/ma17246027

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