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Volume 7
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10.1080/20016689.2019.1678563
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Journal of Market Access & Health Policy (JMAHP) is published by MDPI from Volume 12 Issue 1 (2024). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Taylor & Francis.
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Article

The Impact of Non-medical Switching among Ambulatory Patients: An Updated Systematic Literature Review

by
Erin R. Weeda
1,
Elaine Nguyen
2,
Silas Martin
3,
Michael Ingham
3,
Diana M. Sobieraj
4,
Brahim K. Bookhart
3 and
Craig I. Coleman
4,*
1
The College of Pharmacy, Medical University of South Carolina, Charleston, SC, USA
2
Department of Pharmacy Practice, Idaho State University College of Pharmacy, Boise, ID, USA
3
Real World Value & Evidence, Janssen Scientific Affairs, LLC, Titusville, NJ, USA
4
University of Connecticut School of Pharmacy, Storrs, CT, USA
*
Author to whom correspondence should be addressed.
J. Mark. Access Health Policy 2019, 7(1), 1678563; https://doi.org/10.1080/20016689.2019.1678563
Submission received: 7 May 2019 / Revised: 28 September 2019 / Accepted: 4 October 2019 / Published: 19 October 2019

Abstract

Background: Non-medical switching (NMS) is defined as switching to a clinically similar but chemically distinct medication for reasons apart from lack of effectiveness, tolerability or adherence. Objective: To update a prior systematic review evaluating the impact of NMS on outcomes. Data sources: An updated search through 10/1/2018 in Medline and Web of Science was performed. Study selection: We included studies evaluating ?25 patients and measuring the impact of NMS of drugs on ?1 endpoint. Data extraction: The direction of association between NMS and endpoints was classified as negative, positive or neutral. Data synthesis: Thirty-eight studies contributed 154 endpoints. The direction of association was negative (n = 48; 31.2%) or neutral (n = 91; 59.1%) more often than it was positive (n = 15; 9.7%). Stratified by endpoint type, NMS was associated with a negative impact on clinical, economic, healthcare utilization and medication-taking behavior in 26.9%,41.7%,30.3% and 75.0% of cases; with a positive effect seen in 3.0% (resource utilization) to 14.0% (clinical) of endpoints. Of the 92 endpoints from studies performed by the entity dictating the NMS, 88.0%were neutral or positive; whereas, only 40.3%of endpoints from studies conducted separately from the interested entity were neutral or positive. Conclusions: NMS was commonly associated with negative or neutral endpoints and was seldom associated with positive ones.
Keywords: managed care; non-medical switch; outcome assessment; therapeutic interchange managed care; non-medical switch; outcome assessment; therapeutic interchange

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MDPI and ACS Style

Weeda, E.R.; Nguyen, E.; Martin, S.; Ingham, M.; Sobieraj, D.M.; Bookhart, B.K.; Coleman, C.I. The Impact of Non-medical Switching among Ambulatory Patients: An Updated Systematic Literature Review. J. Mark. Access Health Policy 2019, 7, 1678563. https://doi.org/10.1080/20016689.2019.1678563

AMA Style

Weeda ER, Nguyen E, Martin S, Ingham M, Sobieraj DM, Bookhart BK, Coleman CI. The Impact of Non-medical Switching among Ambulatory Patients: An Updated Systematic Literature Review. Journal of Market Access & Health Policy. 2019; 7(1):1678563. https://doi.org/10.1080/20016689.2019.1678563

Chicago/Turabian Style

Weeda, Erin R., Elaine Nguyen, Silas Martin, Michael Ingham, Diana M. Sobieraj, Brahim K. Bookhart, and Craig I. Coleman. 2019. "The Impact of Non-medical Switching among Ambulatory Patients: An Updated Systematic Literature Review" Journal of Market Access & Health Policy 7, no. 1: 1678563. https://doi.org/10.1080/20016689.2019.1678563

APA Style

Weeda, E. R., Nguyen, E., Martin, S., Ingham, M., Sobieraj, D. M., Bookhart, B. K., & Coleman, C. I. (2019). The Impact of Non-medical Switching among Ambulatory Patients: An Updated Systematic Literature Review. Journal of Market Access & Health Policy, 7(1), 1678563. https://doi.org/10.1080/20016689.2019.1678563

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