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Infectious Disease Reports
Volume 14
Issue 1
10.3390/idr14010011
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Case Report
Peer-Review Record

COVID-19 mRNA Vaccination Mimicking Heart Attack in a Healthy 56-Year-Old Physician

Infect. Dis. Rep. 2022, 14(1), 93-97; https://doi.org/10.3390/idr14010011
by Ioannis Xinias 1,*, Antigoni Mavroudi 1, Georgios-Theofilos Theodorou 2 and Ioannis Roilidis 1
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Infect. Dis. Rep. 2022, 14(1), 93-97; https://doi.org/10.3390/idr14010011
Submission received: 17 December 2021 / Revised: 24 January 2022 / Accepted: 25 January 2022 / Published: 27 January 2022
(This article belongs to the Section Immunology and Vaccines)

Round 1

Reviewer 1 Report

The authors summarize a side effect of the pfizer/biontech vaccine. The patient has shown a heart attack related symptom and the authors assume that this side effect is so important which needs to get published. As this kind of side effects are not unusual and the case report does not actually provide new insights, I feel that such case reports are still important to show readers which kind of symptoms may vaccines cause. 

please cite the whole second paragraph of the introduction section

please add the electrocardiography

please add the heart enzymes

Author Response

Thank you for considering this as an important case report for readers to be aware of.

We have now added the citation for the second paragraph regarding allergic reactions. Both the lab results (including cardiac enzymes) and the ECG have been submitted as a table and picture respectively. 

Kind regards

Reviewer 2 Report

This is a very interesting paper. 

1. Did you consider performing MRI to exclude myocarditis?

2. Could you provide in conclusions some advice on how physicians can distinguish post-vaccination pain from angina? What should we take into account in GPs practice?

Author Response

Thank you for your interest in our case report.

Regarding your first question; an MRI could potentially have been performed, however the short duration of symptoms and quick resolution in combination with no pathological findings from the primary testing (blood tests and ECG) and the age of our patient (knowing that myocarditis has been noted in younger ages mostly) deterred us from doing so.

The advice that could be included in the conclusion would be to prefer vaccinating in the right arm so in case such symptoms do occur they may be localised more in the right. In addition a GP practice could take into consideration the age of the patient, background cardiac health history, time from vaccination and site of vaccination, as mentioned above, in conjunction with an ECG to stratify how much of an emergency a patient presenting to their practice might be.

 

Round 2

Reviewer 1 Report

The authors provide a revised version of the manuscript. All my comments were appropriately addressed.

Author Response

Many thanks

This manuscript is a resubmission of an earlier submission. The following is a list of the peer review reports and author responses from that submission.


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