Burden of Disease Due to Respiratory Syncytial Virus in Adults in Five Middle-Income Countries
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Sources
2.2. Outcomes
2.3. Statistical Analysis
3. Results
3.1. Argentina
3.2. Brazil
3.3. Chile
3.4. Mexico
3.5. Malaysia
4. Discussion
- Respiratory syncytial virus (RSV) is an important cause of severe respiratory disease in older adults but may frequently go unrecognized.
- Understanding the burden of disease guides the use of preventative vaccines.
- By using hospital and death statistics from Argentina, Brazil, Chile, Mexico, and Malaysia, this study showed large numbers of hospitalizations and deaths due to RSV in each country. Rates were highest in winter and were much higher in adults from the age of 65 years. Almost all RSV deaths occurred in this age group.
- In view of the frequency and severity of RSV infections in older adults, prevention through vaccination should be prioritized.
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Hospital Discharges Due to Any Respiratory Diseases (J00–J99) | Deaths Due to Any Respiratory Diseases (J00–J99) | |||||
---|---|---|---|---|---|---|
Age Groups | % Attributable to RSV | Lower Limit | Upper Limit | % Attributable to RSV | Lower Limit | Upper Limit |
18–49 years | 1.40% | 1.26% | 2.10% | 4.20% | 0.00% | 9.04% |
50–64 years | 5.20% | 3.92% | 6.41% | 5.90% | 4.72% | 6.61% |
65–74 years | 5.80% | 4.19% | 6.83% | 5.70% | 4.18% | 6.56% |
≥75 years | 6.80% | 5.24% | 8.47% | 5.90% | 4.12% | 8.12% |
Country | Age Group (Years) | Population | Hospitalizations Due to Any Respiratory Disease (J00–J99) | RSV-Attributable Hospitalizations | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Number ║ | Number | Incidence/100,000 | Number | LL | UL | Incidence/100,000 Population | LL | UL | ||
Argentina * | 20–49 | 6,878,499 | 36,253 | 527.0 | 1410 | 1269 | 2115 | 7.4 | 6.6 | 11.1 |
50–64 | 2,234,244 | 27,845 | 1246.3 | 4022 | 3029 | 4957 | 64.8 | 48.8 | 79.9 | |
65–74 | 1,059,359 | 20,804 | 1963.8 | 3352 | 2423 | 3948 | 113.9 | 82.4 | 134.2 | |
≥75 | 778,069 | 30,811 | 3959.9 | 5820 | 4483 | 7248 | 269.3 | 207.4 | 335.4 | |
Total | 10,950,171 * | 115,713 | 1056.7 | 14,604 | 11,205 | 18,269 | 48.0 | 36.8 | 60.1 | |
Brazil ** | 20–49 | 74,510,220 | 158,903 | 213.3 | 2900 | 2611 | 4352 | 3.0 | 2.7 | 4.5 |
50–64 | 24,980,691 | 147,369 | 589.9 | 9991 | 7525 | 12,314 | 30.7 | 23.1 | 37.8 | |
65–74 | 9,400,404 | 137,632 | 1464.1 | 10,408 | 7525 | 12,259 | 84.9 | 61.4 | 100.0 | |
≥75 | 5,942,023 | 237,132 | 3990.8 | 21,023 | 16,196 | 26,183 | 271.4 | 209.1 | 338.0 | |
Total | 114,833,339 | 681,036 | 593.1 | 44,323 | 33,857 | 55,108 | 29.6 | 22.6 | 36.8 | |
Chile | 18–49 | 9,085,578 | 24,300 | 267.5 | 340 | 306 | 510 | 3.7 | 3.4 | 5.6 |
50–64 | 3,300,485 | 16,274 | 493.1 | 846 | 637 | 1043 | 25.6 | 19.3 | 31.6 | |
65–74 | 1,335,405 | 16,754 | 1254.6 | 972 | 703 | 1145 | 72.8 | 52.6 | 85.7 | |
≥75 | 924,817 | 34,860 | 3769.4 | 2370 | 1826 | 2952 | 256.3 | 197.5 | 319.2 | |
Total | 14,646,285 | 92,188 | 629.4 | 4529 | 3472 | 5650 | 30.9 | 23.7 | 38.6 | |
Mexico † | 20–49 | 44,664,930 | 44,013 | 98.5 | 770 | 693 | 1156 | 1.4 | 1.2 | 2.1 |
50–64 | 13,336,814 | 33,025 | 247.6 | 2147 | 1617 | 2646 | 12.9 | 9.7 | 15.9 | |
65–74 | 4,525,402 | 26,264 | 580.4 | 1904 | 1377 | 2243 | 33.7 | 24.3 | 39.6 | |
≥75 | 2,867,701 | 45,060 | 1571.3 | 3830 | 2951 | 4770 | 106.8 | 82.3 | 133.1 | |
Total | 65,394,847 | 148,362 | 226.9 | 8651 | 6638 | 10,814 | 10.6 | 8.1 | 13.2 | |
Malaysia | 20–49 | 15,823,700 | 43,042 | 272.0 | 603 | 543 | 904 | 3.8 | 3.4 | 5.7 |
50–64 | 4,558,200 | 45,925 | 1007.5 | 2388 | 1799 | 2943 | 52.4 | 39.5 | 64.6 | |
65–74 | 1,566,400 | 38,438 | 2453.9 | 2229 | 1612 | 2626 | 142.3 | 102.9 | 167.6 | |
≥75 | 746,100 | 32,288 | 4327.6 | 2196 | 1691 | 2734 | 294.3 | 226.7 | 366.5 | |
Total | 22,694,400 | 159,693 | 703.7 | 7416 | 5645 | 9208 | 32.7 | 24.9 | 40.6 |
Country | Age Group (Years) | Population | Deaths Due to Any Respiratory Disease (J00–J99) | RSV-Attributable Deaths | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Number | Incidence/100,000 | Number | LL | UL | Mortality/100,000 | LL | UL | |||
Argentina | 20–49 | 19,106,941 | 2219 | 12 | 93 | - | 201 | 0.5 | 0.0 | 1.1 |
50–64 | 6,206,232 | 5807 | 94 | 343 | 274 | 384 | 5.5 | 4.4 | 6.2 | |
65–74 | 2,942,665 | 11,288 | 384 | 643 | 471 | 741 | 21.9 | 16.0 | 25.2 | |
≥75 | 2,161,303 | 41,343 | 1913 | 2439 | 1703 | 3358 | 112.9 | 78.8 | 155.4 | |
Total | 30,417,141 | 60,657 | 199 | 3518 | 2448 | 4683 | 11.6 | 8.0 | 15.4 | |
Brazil | 20–49 | 97,145,006 | 9243 | 10 | 388 | - | 836 | 0.4 | 0.0 | 0.9 |
50–64 | 32,569,350 | 21,860 | 67 | 1290 | 1032 | 1445 | 4.0 | 3.2 | 4.4 | |
65–74 | 12,256,068 | 30,431 | 248 | 1735 | 1271 | 1997 | 14.2 | 10.4 | 16.3 | |
≥75 | 7,747,097 | 96,656 | 1248 | 5703 | 3981 | 7851 | 73.6 | 51.4 | 101.3 | |
Total | 149,717,521 | 158,190 | 106 | 9115 | 6284 | 12,129 | 6.1 | 4.2 | 8.1 | |
Chile | 18–49 | 9,085,578 | 417 | 5 | 18 | - | 38 | 0.2 | - | 0.4 |
50–64 | 3,300,485 | 1252 | 38 | 74 | 59 | 83 | 2.2 | 1.8 | 2.5 | |
65–74 | 1,335,405 | 2177 | 163 | 124 | 91 | 143 | 9.3 | 6.8 | 10.7 | |
≥75 | 924,817 | 9931 | 1074 | 586 | 409 | 807 | 63.4 | 44.2 | 87.2 | |
Total | 14,646,285 | 13,777 | 94 | 801 | 559 | 1070 | 5.5 | 3.8 | 7.3 | |
Mexico | 20–49 | 55,831,163 | 5651 | 10 | 237 | - | 511 | 0.4 | - | 0.9 |
50–64 | 16,671,018 | 9416 | 56 | 556 | 445 | 622 | 3.3 | 2.7 | 3.7 | |
65–74 | 5,656,752 | 11,813 | 209 | 673 | 493 | 775 | 11.9 | 8.7 | 13.7 | |
≥75 | 3,584,626 | 39,662 | 1106 | 2340 | 1633 | 3222 | 65.3 | 45.6 | 89.9 | |
Total | 81,743,559 | 66,542 | 81 | 3806 | 2571 | 5130 | 4.7 | 3.1 | 6.3 | |
Malaysia | 20–49 | 15,823,700 | 1678 | 11 | 70 | - | 152 | 0.4 | - | 1.0 |
50–64 | 4,558,200 | 3184 | 70 | 188 | 150 | 210 | 4.1 | 3.3 | 4.6 | |
65–74 | 1,566,400 | 3409 | 218 | 194 | 142 | 224 | 12.4 | 9.1 | 14.3 | |
≥75 | 746,100 | 4253 | 570 | 251 | 175 | 345 | 33.6 | 23.5 | 46.3 | |
Total | 22,694,400 | 12,524 | 55 | 704 | 468 | 931 | 3.1 | 2.1 | 4.1 |
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Gómez, J.A.; Cintra, O.; Berzanskis, A.; Pacheco, S.; Jaswantlal, H.; Hasnaoui, A.E.; van Oorschot, D.A.M.; Guzman-Holst, A. Burden of Disease Due to Respiratory Syncytial Virus in Adults in Five Middle-Income Countries. Infect. Dis. Rep. 2024, 16, 750-762. https://doi.org/10.3390/idr16040057
Gómez JA, Cintra O, Berzanskis A, Pacheco S, Jaswantlal H, Hasnaoui AE, van Oorschot DAM, Guzman-Holst A. Burden of Disease Due to Respiratory Syncytial Virus in Adults in Five Middle-Income Countries. Infectious Disease Reports. 2024; 16(4):750-762. https://doi.org/10.3390/idr16040057
Chicago/Turabian StyleGómez, Jorge A., Otavio Cintra, Arnas Berzanskis, Salma Pacheco, Henny Jaswantlal, Abdelkader El Hasnaoui, Desirée A. M. van Oorschot, and Adriana Guzman-Holst. 2024. "Burden of Disease Due to Respiratory Syncytial Virus in Adults in Five Middle-Income Countries" Infectious Disease Reports 16, no. 4: 750-762. https://doi.org/10.3390/idr16040057