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Infectious Disease Reports
Volume 4
Issue 2
10.4081/idr.2012.e36
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Infectious Disease Reports is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

An Usual Approach to Treatment of a Case of Multidrug Resistance Pseudomonas aeruginosa Peritonitis: Parenteral and Intraperitoneal Aminoglycosides and Parenteral Colistin

by
Ian May
,
Maha Abu-Khdeir
and
Roland Alexander Blackwood
*
Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, MI, USA
*
Author to whom correspondence should be addressed.
Infect. Dis. Rep. 2012, 4(2), e36; https://doi.org/10.4081/idr.2012.e36
Submission received: 19 March 2012 / Revised: 18 June 2012 / Accepted: 20 June 2012 / Published: 18 September 2012

Abstract

Infections caused by Pseudomonas aeruginosa are becoming more common and increasingly more difficult to treat due to the continued development of drug resistance. While sensitivity to colistin (polymyxin E) is well known, it is frequently avoided due to concerns of nephrotoxicity. Reported here is a case of a multi-drug resistance pseudomonal typhlitis, bacteremia and pleural cavity infection that required significant intensive care, and serial abdominal washouts. Intra-peritoneal tobramycin in combination with broad-spectrum intravenous antibiotics including colistin were used. Several instillations of tobramycin into the abdominal cavity along with concomitant IV administration of colistin, ceftazidime and tobramycin and per os colistin, tobramycin and nystatin resulted in the clearance of the pseudomonal infection without any evidence of toxicity from the treatment. Intra-abdominal tobramycin with parenteral colistin therapy can be used in complicated clinical settings with appropriate nephroprotection.
Keywords: Pseudomonas aeruginosa; typhlitis; pediatric; Burkitt’s leukemia; intra-abdominal tobramycin; colistin (polymyxin E) Pseudomonas aeruginosa; typhlitis; pediatric; Burkitt’s leukemia; intra-abdominal tobramycin; colistin (polymyxin E)

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MDPI and ACS Style

May, I.; Abu-Khdeir, M.; Blackwood, R.A. An Usual Approach to Treatment of a Case of Multidrug Resistance Pseudomonas aeruginosa Peritonitis: Parenteral and Intraperitoneal Aminoglycosides and Parenteral Colistin. Infect. Dis. Rep. 2012, 4, e36. https://doi.org/10.4081/idr.2012.e36

AMA Style

May I, Abu-Khdeir M, Blackwood RA. An Usual Approach to Treatment of a Case of Multidrug Resistance Pseudomonas aeruginosa Peritonitis: Parenteral and Intraperitoneal Aminoglycosides and Parenteral Colistin. Infectious Disease Reports. 2012; 4(2):e36. https://doi.org/10.4081/idr.2012.e36

Chicago/Turabian Style

May, Ian, Maha Abu-Khdeir, and Roland Alexander Blackwood. 2012. "An Usual Approach to Treatment of a Case of Multidrug Resistance Pseudomonas aeruginosa Peritonitis: Parenteral and Intraperitoneal Aminoglycosides and Parenteral Colistin" Infectious Disease Reports 4, no. 2: e36. https://doi.org/10.4081/idr.2012.e36

APA Style

May, I., Abu-Khdeir, M., & Blackwood, R. A. (2012). An Usual Approach to Treatment of a Case of Multidrug Resistance Pseudomonas aeruginosa Peritonitis: Parenteral and Intraperitoneal Aminoglycosides and Parenteral Colistin. Infectious Disease Reports, 4(2), e36. https://doi.org/10.4081/idr.2012.e36

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