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Infectious Disease Reports
Volume 7
Issue 3
10.4081/idr.2015.5979
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Infectious Disease Reports is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Serum 25-Hydroxyvitamin D Levels Are not Associated with Adverse Outcomes in Clostridium Difficile Infection

by
Dejan Micic
1,
Krishna Rao
2,3,
Bruno Caetano Trindade
2,4,
Seth T. Walk
2,3,
Elizabeth Chenoweth
5,
Ruchika Jain
2,3,
Itishree Trivedi
2,
Kavitha Santhosh
2,3,
Vincent B. Young
2,3,4 and
David M. Aronoff
2,3,4,*
1
Division of Gastroenterology, Hepatology and Nutrition, University of Chicago, IL, USA
2
Department of Internal Medicine, USA
3
Division of Infectious Diseases, USA
4
Department of Microbiology and Immunology, University of Michigan Health System, Ann Arbor, MI, USA
5
University of Michigan Medical School, Ann Arbor, MI, USA
*
Author to whom correspondence should be addressed.
Infect. Dis. Rep. 2015, 7(3), 5979; https://doi.org/10.4081/idr.2015.5979
Submission received: 2 May 2015 / Revised: 2 May 2015 / Accepted: 26 June 2015 / Published: 29 September 2015

Abstract

Clostridium difficile infection (CDI) is a significant source of healthcare-associated morbidity and mortality. This study investigated whether serum 25-hydroxyvitamin D is associated with adverse outcomes from CDI. Patients with CDI were prospectively enrolled. Charts were reviewed and serum 25-hydroxyvitamin D was measured. The primary outcome was a composite definition of severe disease: fever (temperature >38°C), acute organ dysfunction, or serum white blood cell count >15,000 cells/μL within 24-48 hours of diagnosis; lack of response to therapy by day 5; and intensive care unit admission; colectomy; or death within 30 days. Sixty-seven patients were included in the final analysis. Mean (±SD) serum 25- hydroxyvitamin D was 26.1 (±18.54) ng/mL. Severe disease, which occurred in 26 (39%) participants, was not associated with serum 25-hydroxyvitamin D [odds ratio (OR) 1.00; 95% confidence interval (CI) 0.96-1.04]. In the adjusted model for severe disease only serum albumin (OR 0.12; 95%CI 0.02-0.64) and diagnosis by detection of stool toxin (OR 5.87; 95%CI 1.09-31.7) remained independent predictors. We conclude that serum 25-hydroxyvitamin D is not associated with the development of severe disease in patients with CDI.
Keywords: Vitamin D; Clostridium difficile; colitis; biomarkers Vitamin D; Clostridium difficile; colitis; biomarkers

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MDPI and ACS Style

Micic, D.; Rao, K.; Trindade, B.C.; Walk, S.T.; Chenoweth, E.; Jain, R.; Trivedi, I.; Santhosh, K.; Young, V.B.; Aronoff, D.M. Serum 25-Hydroxyvitamin D Levels Are not Associated with Adverse Outcomes in Clostridium Difficile Infection. Infect. Dis. Rep. 2015, 7, 5979. https://doi.org/10.4081/idr.2015.5979

AMA Style

Micic D, Rao K, Trindade BC, Walk ST, Chenoweth E, Jain R, Trivedi I, Santhosh K, Young VB, Aronoff DM. Serum 25-Hydroxyvitamin D Levels Are not Associated with Adverse Outcomes in Clostridium Difficile Infection. Infectious Disease Reports. 2015; 7(3):5979. https://doi.org/10.4081/idr.2015.5979

Chicago/Turabian Style

Micic, Dejan, Krishna Rao, Bruno Caetano Trindade, Seth T. Walk, Elizabeth Chenoweth, Ruchika Jain, Itishree Trivedi, Kavitha Santhosh, Vincent B. Young, and David M. Aronoff. 2015. "Serum 25-Hydroxyvitamin D Levels Are not Associated with Adverse Outcomes in Clostridium Difficile Infection" Infectious Disease Reports 7, no. 3: 5979. https://doi.org/10.4081/idr.2015.5979

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