Different Clinical Manifestations of Adenoviral Infection Confirmed Using Point-of-Care Testing in a Group of Hospitalized Children
Abstract
:1. Introduction
2. Material and Methods
2.1. Study Design
2.2. Patient Identification and Selection
- Nasopharyngeal swab: Certest Biotec S.L., Spain, Influenza A+ B + RSV + Adeno. (detects serotypes 2, 3, 4, 5, 15, 31, 40, 41). The specimens were collected by trained medical doctors. Results were measured by POC tests.
- Stool: Certest Biotec S.L., Spain, Influenza A+ B + RSV + Adeno. (detects serotypes 2, 5, 15, 31, 40, 41). The test was performed in the microbiology lab of the University Children’s Hospital of Cracow.
2.3. Definitions of the Groups of Patients
2.4. Statistical Methods
3. Results
Laboratory Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Group A (n = 57) | Group B (n = 40) | Group C (n = 38) | p | |
---|---|---|---|---|
Age (months; Median; IQR) | 17 (12–30) | 30 (16–50) | 17 (12–27) | 0.04 * |
Age <12 months 12–24 months >24 months | 15 23 19 | 4 14 22 | 9 19 10 | 0.066 # |
Fever before admission n (%) | 54 (94.7%) | 16 (40%) | 30 (78.9%) | <0.001 # |
Antibiotics before admission n (%) | 24 (42.1%) | 3 (7.5%) | 14 (36.8%) | 0.001 # |
Duration of fever before admission only feverish patients (days; median; IQR) | 3 (1–5) | 1 (1–2) | 3 (1–4) | 0.01 * |
LOS (days), median (IQR) | 4 (3–6) | 3 (3–5) | 4 (3–5) | 0.14 * |
Group A (n = 57) | Group B (n = 40) | Group C (n = 38) | p * | |
---|---|---|---|---|
Positive nasopharyngeal swab for adenovirus antigen | 47 | 7 | 22 | <0.01 |
Positive stool test for adenovirus antigen | 10 | 32 | 15 | <0.01 |
Positive both tests for adenovirus antigen | 0 | 1 | 1 | <0.01 |
Group A (n = 57) | Group B (n = 40) | Group C (n = 38) | p * | |
---|---|---|---|---|
WBC (×103/μL Median; IQR) | 13.5 (10.3–18.9) | 12.3 (8.1–15.2) | 13.7 (9.2–18.7) | 0.29 |
ANC (×103/μL Median; IQR) | 6.8 (5–10.9) | 6.8 (4.7–10.7) | 6.4 (4.4–12.7) | 0.98 |
ALC (×103/μL Median; IQR) | 4.5 (2.9–6.6) | 2.8 (1.6–4.1) | 4.3 (2.9–5.9) | 0.001 |
PLT (×103/μL Median; IQR) | 308 (251–370) | 332 (273–405) | 325 (289–363) | 0.36 |
CRP (mg/L; Median; IQR) | 29.2 (10.4–69.1) | <5 (<5–20.6) | 28.7 (10.8–49.1) | <0.001 |
CRP among age groups (mg/L; Median; IQR) | ||||
<12 months | 21.5 (5.4–28) | 10.1 (<5–38.9) | 29.2 (18.2–57) | 0.566 |
12–24 months | 37.4 (12.7–69) | <5 (<5–19.3) | 23.5(7.2–46) | 0.025 |
>24 months | 30 (7–133) | <5 (<5–21.1) | 31.3 (10.8–56.4) | 0.013 |
Group A (n = 57) | Group B (n = 40) | Group C (n = 38) | p * | |
---|---|---|---|---|
Children with fever children (mg/L; median; IQR) | 30.2 (10.4–69.2) | 19.9 (13.3–6.3) | 40.6 (22–57) | 0.721 |
Children without fever (mg/L, median; IQR) | 15.7 (5.2–21.1) | <5 (<5–<5) | <5 (<5–10) | 0.019 |
Children who received antibiotics prior to admission (mg/L; median; IQR) | 29 (11.6–59) | 34 (<5–64) | 35.3 (14–49) | 0.97 |
Children without antibiotics prior to admission (mg/L; median;IQR) | 29.2 (6.9–121) | <5 (<5–19.3) | 26.4 (9.8–56) | 0.001 |
Children with LRTI (mg/L; median; IQR) | 24.3 (9–46) | N/D | 28.2 (9.5–49.1) | 1.0 |
Children without LRTI (mg/L;median;IQR) | 30.2 (10.4–115.6) | <5 (<5–20.6) | 35.8 (22.7–57.5) | 0.001 |
Children with AOM (mg/L; median; IQR) | 69.1 (12.8–154) | N/D | 24.9 (5–44.8) | 0.32 |
Children without AOM (mg/L;median;IQR) | 27.7 (9–60) | <5 (<5–20.6) | 28.7 (12–52.6) | 0.001 |
Group A (n = 57) | Group B (n = 40) | Group C (n = 38) | p * | |
---|---|---|---|---|
CRP > 15 mg/L | 39 (68%) | 14 (35%) | 26 (68%) | 0.002 |
CRP > 100 Mg/L | 12 (21%) | 1 (2.5%) | 3 (7.8%) | 0.016 |
CRP > 15 Mg/L | ||||
<12 months | 10 (66%) | 2 (50%) | 7 (77%) | 0.6 |
12–24 months | 16 (70%) | 5 (36%) | 12 (63%) | 0.11 |
>24 months | 13 (65%) | 7 (32%) | 7 (70%) | 0.044 |
CRP > 15 Mg/L | ||||
Fever | 37 (67%) | 12 (75%) | 24 (80%) | 0.44 |
No fever | 2 (67%) | 2 (8%) | 1 (14%) | 0.08 |
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Ptak, K.; Szymońska, I.; Olchawa-Czech, A.; Baliga, Z.; Sawina, M.; Woźnica, A.; Kwinta, P. Different Clinical Manifestations of Adenoviral Infection Confirmed Using Point-of-Care Testing in a Group of Hospitalized Children. Pediatr. Rep. 2023, 15, 1-8. https://doi.org/10.3390/pediatric15010001
Ptak K, Szymońska I, Olchawa-Czech A, Baliga Z, Sawina M, Woźnica A, Kwinta P. Different Clinical Manifestations of Adenoviral Infection Confirmed Using Point-of-Care Testing in a Group of Hospitalized Children. Pediatric Reports. 2023; 15(1):1-8. https://doi.org/10.3390/pediatric15010001
Chicago/Turabian StylePtak, Katarzyna, Izabela Szymońska, Anna Olchawa-Czech, Zuzanna Baliga, Marta Sawina, Agata Woźnica, and Przemko Kwinta. 2023. "Different Clinical Manifestations of Adenoviral Infection Confirmed Using Point-of-Care Testing in a Group of Hospitalized Children" Pediatric Reports 15, no. 1: 1-8. https://doi.org/10.3390/pediatric15010001
APA StylePtak, K., Szymońska, I., Olchawa-Czech, A., Baliga, Z., Sawina, M., Woźnica, A., & Kwinta, P. (2023). Different Clinical Manifestations of Adenoviral Infection Confirmed Using Point-of-Care Testing in a Group of Hospitalized Children. Pediatric Reports, 15(1), 1-8. https://doi.org/10.3390/pediatric15010001