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Volume 9
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10.4081/pr.2017.6984
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Case Report

Stroke in a Child with Hemoglobin SC Disease: A Case Report Describing Use of Hydroxyurea after Transfusion Therapy

by
Diana Fridlyand
1,
Caroline Wilder
1,
E. Leila Jerome Clay
1,
Bruce Gilbert
1 and
Betty S. Pace
1,*
1
Department of Pediatrics, Augusta University, GA, USA
2
Department of Radiology, Augusta University, GA, USA
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2017, 9(1), 6984; https://doi.org/10.4081/pr.2017.6984
Submission received: 20 November 2016 / Revised: 16 February 2017 / Accepted: 17 February 2017 / Published: 22 March 2017

Abstract

Children with hemoglobin SC (HbSC) disease suffer a significant incidence of silent cerebral infarcts but stroke is rare. A 2-year-old African American boy with HbSC disease presented with focal neurologic deficits associated with magnetic resonance imaging evidence of cerebral infarction with vascular abnormalities. After the acute episode he was treated with monthly transfusions and subsequently transitioned to hydroxyurea therapy. The benefits of hydroxyurea as a fetal hemoglobin inducer in HbSC disease, to ameliorate clinical symptoms are supported by retrospective studies. This case highlights the rare occurrence of stroke in a child with HbSC disease and the use of hydroxyurea therapy.
Keywords: Hemoglobin SC disease; hydroxyurea; cerebral infarct; sickle cell anemia; hematology Hemoglobin SC disease; hydroxyurea; cerebral infarct; sickle cell anemia; hematology

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MDPI and ACS Style

Fridlyand, D.; Wilder, C.; Jerome Clay, E.L.; Gilbert, B.; Pace, B.S. Stroke in a Child with Hemoglobin SC Disease: A Case Report Describing Use of Hydroxyurea after Transfusion Therapy. Pediatr. Rep. 2017, 9, 6984. https://doi.org/10.4081/pr.2017.6984

AMA Style

Fridlyand D, Wilder C, Jerome Clay EL, Gilbert B, Pace BS. Stroke in a Child with Hemoglobin SC Disease: A Case Report Describing Use of Hydroxyurea after Transfusion Therapy. Pediatric Reports. 2017; 9(1):6984. https://doi.org/10.4081/pr.2017.6984

Chicago/Turabian Style

Fridlyand, Diana, Caroline Wilder, E. Leila Jerome Clay, Bruce Gilbert, and Betty S. Pace. 2017. "Stroke in a Child with Hemoglobin SC Disease: A Case Report Describing Use of Hydroxyurea after Transfusion Therapy" Pediatric Reports 9, no. 1: 6984. https://doi.org/10.4081/pr.2017.6984

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