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Volume 10
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10.4081/pb.2019.7458
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International Journal of Plant Biology is published by MDPI from Volume 13 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Evaluation of Antidepressant-like Effect Lavandulifolia stachys in the Forced Swimming Test in Comparison with Imipramine and Fluoxetine

by
Shirali Kharamin
1,
Saeed Razmeh
1,*,
Mona Nabovvati
2,
Karim Moradian
3,
Samaneh Rahimi
4,
Maryam Orooji
5,
Laleh Taghavian
1 and
Majid Kherad Mand Maher
6
1
Yasuj University of Medical Sciences, Yasuj, Iran
2
Iran University of Medical Sciences, Tehran, Iran
3
Kermanshah University of Medical Sciences, Kermanshah, Iran
4
Shiraz University of Medical Sciences, Shiraz, Iran
5
Alborz University of Medical Sciences, Alborz, Iran
6
University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
*
Author to whom correspondence should be addressed.
Int. J. Plant Biol. 2019, 10(1), 7458; https://doi.org/10.4081/pb.2019.7458
Submission received: 31 October 2018 / Revised: 6 November 2018 / Accepted: 6 November 2018 / Published: 12 June 2019

Abstract

Depression is a global problem associated with multiple social and health issues. In the present study, we analyzed the antidepressant effects of Lavandulifolia stachys, an herbal planton forced swimming test (FST). In this study, 36 rats were used. We gavaged the aqueous extract of plant (50, 100, 150 mg/kg), imipramine and fluoxetine (20 mg/kg) as standard antidepressant drug and normal saline for control group for a week. Then, their behavioral responses including climbing, swimming and immobility were recorded during the 5-min FST. Our experiments showed significant effects of Lavandulifolia stachys on swimming and immobility but not effect on climbing behaviors. Imipramine and fluoxetine increased climbing and swimming, respectively, and both reduced immobility, compared to saline control. Finally, our results show the extract of Lavandulifolia stachys could play an important role in treatment of depression like fluoxetine.
Keywords: Lavandulifolia stachys; fluoxetine; imipramine; depression; forced swimming test Lavandulifolia stachys; fluoxetine; imipramine; depression; forced swimming test

Share and Cite

MDPI and ACS Style

Kharamin, S.; Razmeh, S.; Nabovvati, M.; Moradian, K.; Rahimi, S.; Orooji, M.; Taghavian, L.; Mand Maher, M.K. Evaluation of Antidepressant-like Effect Lavandulifolia stachys in the Forced Swimming Test in Comparison with Imipramine and Fluoxetine. Int. J. Plant Biol. 2019, 10, 7458. https://doi.org/10.4081/pb.2019.7458

AMA Style

Kharamin S, Razmeh S, Nabovvati M, Moradian K, Rahimi S, Orooji M, Taghavian L, Mand Maher MK. Evaluation of Antidepressant-like Effect Lavandulifolia stachys in the Forced Swimming Test in Comparison with Imipramine and Fluoxetine. International Journal of Plant Biology. 2019; 10(1):7458. https://doi.org/10.4081/pb.2019.7458

Chicago/Turabian Style

Kharamin, Shirali, Saeed Razmeh, Mona Nabovvati, Karim Moradian, Samaneh Rahimi, Maryam Orooji, Laleh Taghavian, and Majid Kherad Mand Maher. 2019. "Evaluation of Antidepressant-like Effect Lavandulifolia stachys in the Forced Swimming Test in Comparison with Imipramine and Fluoxetine" International Journal of Plant Biology 10, no. 1: 7458. https://doi.org/10.4081/pb.2019.7458

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